Increased differentiation associates with decreased polyfunctionality for HIV but not CMV-specific CD8+ T cell responses

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dc.contributor.authorRiou, Cen_ZA
dc.contributor.authorAbrahams, Men_ZA
dc.contributor.authorMlisana, Ken_ZA
dc.contributor.authorKoup, Ren_ZA
dc.contributor.authorRoederer, Men_ZA
dc.contributor.authorKarim, Sen_ZA
dc.contributor.authorde Bruyn, Gen_ZA
dc.contributor.authorWilliamson, Cen_ZA
dc.contributor.authorGray, CMen_ZA
dc.contributor.authorBurgers, WAen_ZA
dc.date.accessioned2015-11-23T11:37:08Z
dc.date.available2015-11-23T11:37:08Z
dc.date.issued2012en_ZA
dc.description.abstractThe generation of polyfunctional CD8+ T cells, in response to vaccination or natural infection, has been associated with improved protective immunity. However, it remains unclear whether the maintenance of polyfunctionality is linked to particular phenotypic characteristics of the cell, such as the differentiation stage of memory T cells. The goal of this study was to investigate the relationship between the memory maturation stage and polyfunctional profiles of antigen-specific CD8+ T cells.en_ZA
dc.identifier.apacitationRiou, C., Abrahams, M., Mlisana, K., Koup, R., Roederer, M., Karim, S., ... Burgers, W. (2012). Increased differentiation associates with decreased polyfunctionality for HIV but not CMV-specific CD8+ T cell responses. <i>Retrovirology</i>, http://hdl.handle.net/11427/15218en_ZA
dc.identifier.chicagocitationRiou, C, M Abrahams, K Mlisana, R Koup, M Roederer, S Karim, G de Bruyn, C Williamson, CM Gray, and WA Burgers "Increased differentiation associates with decreased polyfunctionality for HIV but not CMV-specific CD8+ T cell responses." <i>Retrovirology</i> (2012) http://hdl.handle.net/11427/15218en_ZA
dc.identifier.citationRiou, C., Abrahams, M., Mlisana, K., Koup, R., Roederer, M., Karim, S. A., ... & Burgers, W. A. (2012). Increased differentiation associates with decreased polyfunctionality for HIV but not CMV-specific CD8+ T cell responses. Retrovirology, 9(Suppl 2), P250.en_ZA
dc.identifier.ris TY - Journal Article AU - Riou, C AU - Abrahams, M AU - Mlisana, K AU - Koup, R AU - Roederer, M AU - Karim, S AU - de Bruyn, G AU - Williamson, C AU - Gray, CM AU - Burgers, WA AB - The generation of polyfunctional CD8+ T cells, in response to vaccination or natural infection, has been associated with improved protective immunity. However, it remains unclear whether the maintenance of polyfunctionality is linked to particular phenotypic characteristics of the cell, such as the differentiation stage of memory T cells. The goal of this study was to investigate the relationship between the memory maturation stage and polyfunctional profiles of antigen-specific CD8+ T cells. DA - 2012 DB - OpenUCT DO - 10.1186/1742-4690-9-S2-P250 DP - University of Cape Town J1 - Retrovirology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Increased differentiation associates with decreased polyfunctionality for HIV but not CMV-specific CD8+ T cell responses TI - Increased differentiation associates with decreased polyfunctionality for HIV but not CMV-specific CD8+ T cell responses UR - http://hdl.handle.net/11427/15218 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15218
dc.identifier.urihttp://dx.doi.org/10.1186/1742-4690-9-S2-P250
dc.identifier.vancouvercitationRiou C, Abrahams M, Mlisana K, Koup R, Roederer M, Karim S, et al. Increased differentiation associates with decreased polyfunctionality for HIV but not CMV-specific CD8+ T cell responses. Retrovirology. 2012; http://hdl.handle.net/11427/15218.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Medical Microbiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2012 Riou et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceRetrovirologyen_ZA
dc.source.urihttp://www.retrovirology.com/en_ZA
dc.subject.otherpolyfunctionalityen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherCMV-specific CD8+ T cell responsesen_ZA
dc.titleIncreased differentiation associates with decreased polyfunctionality for HIV but not CMV-specific CD8+ T cell responsesen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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