Quality of life of HIV-infected individuals in a community-based antiretroviral programme

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dc.contributor.authorPitt, Jenniferen_ZA
dc.contributor.authorMyer, Landonen_ZA
dc.contributor.authorWood, Ren_ZA
dc.date.accessioned2015-12-07T08:53:16Z
dc.date.available2015-12-07T08:53:16Z
dc.date.issued2008en_ZA
dc.description.abstractPurpose of the study: The impact of HAART on health-related quality of life (HRQoL) has been widely researched in the developed world, however, there is limited data coming out of the developing world and, in particular, sub-Saharan Africa, where the vast majority of HIV-infected individuals live. This study examined HRQoL among HIV-positive individuals initiating HAART at the Hannan Crusaid Treatment Centre in Gugulethu, Cape Town, and explored the impact of HAART-related drug toxicities on HRQoL. Methods: HRQoL was assessed using a standardised questionnaire, the Medical Outcomes Survey Short Form 36 (MOS SF36). Physical health summary (PHS) scores and mental health summary (MHS) scores were compared pre-HAART and at regular intervals during the first 48 weeks of HAART. The impact of drug toxicities on HRQoL was described and assessed both in unadjusted bivariate and adjusted multivariate analyses. Summary of results: This study reported a significant increase in HRQoL during the first 48 weeks on HAART with the bulk of this increase occurring during the first 16 weeks. Although there was a general improvement in HRQoL on HAART, 23% of participants reported a decline in PHS score, and 34% a decline in MHS score. Average drops in median PHS and MHS scores were 8.4 units (SD 9.31) and 9.9 units (SD 11.4), respectively. Eleven (4%) participants reported drug toxicity. Most toxicities (63%) occurred between weeks 32 and 48, and 73% were related to stavudine. Participants who experienced drug toxicity reported lower PHS scores than participants without a drug toxicity at all time points. However, only 27% (three) of participants with drug toxicity reported a decline in HRQoL between pre-HAART and week 48. Drug toxicities had little impact on MHS scores. Conclusion: This study confirmed the HRQoL benefits of HAART in a community ARV clinic in South Africa. While the majority of patients experienced a significant improvement in HRQoL on HAART, up to a third of patients reported declines in HRQoL. HAART-related drug toxicities (including those secondary to the use of stavudine) did not have a significant negative impact on HRQoL during the first 48 weeks of HAART supporting the ongoing use of stavudine in the national ARV roll-out programme.en_ZA
dc.identifier.apacitationPitt, J., Myer, L., & Wood, R. (2008). Quality of life of HIV-infected individuals in a community-based antiretroviral programme. <i>Journal of the International AIDS Society</i>, http://hdl.handle.net/11427/15662en_ZA
dc.identifier.chicagocitationPitt, Jennifer, Landon Myer, and R Wood "Quality of life of HIV-infected individuals in a community-based antiretroviral programme." <i>Journal of the International AIDS Society</i> (2008) http://hdl.handle.net/11427/15662en_ZA
dc.identifier.citationPitt, J., Myer, L., & Wood, R. (2008). Quality of life of HIV-infected individuals in a community-based antiretroviral programme. Journal of the International AIDS Society, 11(1), 1-1.en_ZA
dc.identifier.ris TY - Journal Article AU - Pitt, Jennifer AU - Myer, Landon AU - Wood, R AB - Purpose of the study: The impact of HAART on health-related quality of life (HRQoL) has been widely researched in the developed world, however, there is limited data coming out of the developing world and, in particular, sub-Saharan Africa, where the vast majority of HIV-infected individuals live. This study examined HRQoL among HIV-positive individuals initiating HAART at the Hannan Crusaid Treatment Centre in Gugulethu, Cape Town, and explored the impact of HAART-related drug toxicities on HRQoL. Methods: HRQoL was assessed using a standardised questionnaire, the Medical Outcomes Survey Short Form 36 (MOS SF36). Physical health summary (PHS) scores and mental health summary (MHS) scores were compared pre-HAART and at regular intervals during the first 48 weeks of HAART. The impact of drug toxicities on HRQoL was described and assessed both in unadjusted bivariate and adjusted multivariate analyses. Summary of results: This study reported a significant increase in HRQoL during the first 48 weeks on HAART with the bulk of this increase occurring during the first 16 weeks. Although there was a general improvement in HRQoL on HAART, 23% of participants reported a decline in PHS score, and 34% a decline in MHS score. Average drops in median PHS and MHS scores were 8.4 units (SD 9.31) and 9.9 units (SD 11.4), respectively. Eleven (4%) participants reported drug toxicity. Most toxicities (63%) occurred between weeks 32 and 48, and 73% were related to stavudine. Participants who experienced drug toxicity reported lower PHS scores than participants without a drug toxicity at all time points. However, only 27% (three) of participants with drug toxicity reported a decline in HRQoL between pre-HAART and week 48. Drug toxicities had little impact on MHS scores. Conclusion: This study confirmed the HRQoL benefits of HAART in a community ARV clinic in South Africa. While the majority of patients experienced a significant improvement in HRQoL on HAART, up to a third of patients reported declines in HRQoL. HAART-related drug toxicities (including those secondary to the use of stavudine) did not have a significant negative impact on HRQoL during the first 48 weeks of HAART supporting the ongoing use of stavudine in the national ARV roll-out programme. DA - 2008 DB - OpenUCT DO - 10.1186/1758-2652-11-S1-P159 DP - University of Cape Town J1 - Journal of the International AIDS Society LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Quality of life of HIV-infected individuals in a community-based antiretroviral programme TI - Quality of life of HIV-infected individuals in a community-based antiretroviral programme UR - http://hdl.handle.net/11427/15662 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15662
dc.identifier.urihttp://dx.doi.org/10.1186/1758-2652-11-S1-P159
dc.identifier.vancouvercitationPitt J, Myer L, Wood R. Quality of life of HIV-infected individuals in a community-based antiretroviral programme. Journal of the International AIDS Society. 2008; http://hdl.handle.net/11427/15662.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holderPitt et al 2008. This article is published under license to BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_ZA
dc.sourceJournal of the International AIDS Societyen_ZA
dc.source.urihttp://www.jiasociety.org/index.php/jiasen_ZA
dc.subject.otherHIV/AIDSen_ZA
dc.subject.otherTreatment Programmesen_ZA
dc.subject.otherQuality of Lifeen_ZA
dc.titleQuality of life of HIV-infected individuals in a community-based antiretroviral programmeen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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