Children in reviews: Methodological issues in child-relevant evidence syntheses

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dc.contributor.authorCramer, Kristieen_ZA
dc.contributor.authorWiebe, Natashaen_ZA
dc.contributor.authorMoyer, Virginiaen_ZA
dc.contributor.authorHartling, Lisaen_ZA
dc.contributor.authorWilliams, Katrinaen_ZA
dc.contributor.authorSwingler, Georgeen_ZA
dc.contributor.authorKlassen, Terryen_ZA
dc.date.accessioned2015-10-12T11:01:04Z
dc.date.available2015-10-12T11:01:04Z
dc.date.issued2005en_ZA
dc.description.abstractBACKGROUND:The delivery of optimal medical care to children is dependent on the availability of child relevant research. Our objectives were to: i) systematically review and describe how children are handled in reviews of drug interventions published in the Cochrane Database of Systematic Reviews (CDSR); and ii) determine when effect sizes for the same drug interventions differ between children and adults. METHODS: We systematically identified all of the reviews relevant to child health in the CDSR 2002, Issue 4. Reviews were included if they investigated the efficacy or effectiveness of a drug intervention for a condition that occurs in both children and adults. Information was extracted on review characteristics including study methods, results, and conclusions. RESULTS: From 1496 systematic reviews, 408 (27%) were identified as relevant to both adult and child health; 52% (213) of these included data from children. No significant differences were found in effect sizes between adults and children for any of the drug interventions or conditions investigated. However, all of the comparisons lacked the power to detect a clinically significant difference and wide confidence intervals suggest important differences cannot be excluded. A large amount of data was unavailable due to inadequate reporting at the trial and systematic review level. CONCLUSION: Overall, the findings of this study indicate there is a paucity of child-relevant and specific evidence generated from evidence syntheses of drug interventions. The results indicate a need for a higher standard of reporting for participant populations in studies of drug interventions.en_ZA
dc.identifier.apacitationCramer, K., Wiebe, N., Moyer, V., Hartling, L., Williams, K., Swingler, G., & Klassen, T. (2005). Children in reviews: Methodological issues in child-relevant evidence syntheses. <i>BMC Pediatrics</i>, http://hdl.handle.net/11427/14212en_ZA
dc.identifier.chicagocitationCramer, Kristie, Natasha Wiebe, Virginia Moyer, Lisa Hartling, Katrina Williams, George Swingler, and Terry Klassen "Children in reviews: Methodological issues in child-relevant evidence syntheses." <i>BMC Pediatrics</i> (2005) http://hdl.handle.net/11427/14212en_ZA
dc.identifier.citationCramer, K., Wiebe, N., Moyer, V., Hartling, L., Williams, K., Swingler, G., & Klassen, T. P. (2005). Children in reviews: methodological issues in child-relevant evidence syntheses. BMC pediatrics, 5(1), 38.en_ZA
dc.identifier.ris TY - Journal Article AU - Cramer, Kristie AU - Wiebe, Natasha AU - Moyer, Virginia AU - Hartling, Lisa AU - Williams, Katrina AU - Swingler, George AU - Klassen, Terry AB - BACKGROUND:The delivery of optimal medical care to children is dependent on the availability of child relevant research. Our objectives were to: i) systematically review and describe how children are handled in reviews of drug interventions published in the Cochrane Database of Systematic Reviews (CDSR); and ii) determine when effect sizes for the same drug interventions differ between children and adults. METHODS: We systematically identified all of the reviews relevant to child health in the CDSR 2002, Issue 4. Reviews were included if they investigated the efficacy or effectiveness of a drug intervention for a condition that occurs in both children and adults. Information was extracted on review characteristics including study methods, results, and conclusions. RESULTS: From 1496 systematic reviews, 408 (27%) were identified as relevant to both adult and child health; 52% (213) of these included data from children. No significant differences were found in effect sizes between adults and children for any of the drug interventions or conditions investigated. However, all of the comparisons lacked the power to detect a clinically significant difference and wide confidence intervals suggest important differences cannot be excluded. A large amount of data was unavailable due to inadequate reporting at the trial and systematic review level. CONCLUSION: Overall, the findings of this study indicate there is a paucity of child-relevant and specific evidence generated from evidence syntheses of drug interventions. The results indicate a need for a higher standard of reporting for participant populations in studies of drug interventions. DA - 2005 DB - OpenUCT DO - 10.1186/1471-2431-5-38 DP - University of Cape Town J1 - BMC Pediatrics LK - https://open.uct.ac.za PB - University of Cape Town PY - 2005 T1 - Children in reviews: Methodological issues in child-relevant evidence syntheses TI - Children in reviews: Methodological issues in child-relevant evidence syntheses UR - http://hdl.handle.net/11427/14212 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14212
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2431-5-38
dc.identifier.vancouvercitationCramer K, Wiebe N, Moyer V, Hartling L, Williams K, Swingler G, et al. Children in reviews: Methodological issues in child-relevant evidence syntheses. BMC Pediatrics. 2005; http://hdl.handle.net/11427/14212.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Paediatrics and Child Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceBMC Pediatricsen_ZA
dc.source.urihttp://www.biomedcentral.com/1471-2431en_ZA
dc.subject.otherChild-relevant evidence synthesesen_ZA
dc.subject.otherdrug interventionsen_ZA
dc.titleChildren in reviews: Methodological issues in child-relevant evidence synthesesen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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