A cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis

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dc.contributor.authorIrlam, James H
dc.contributor.authorMayosi, Bongani M
dc.contributor.authorEngel, Mark E
dc.contributor.authorGaziano, Thomas A
dc.date.accessioned2021-10-08T07:18:01Z
dc.date.available2021-10-08T07:18:01Z
dc.date.issued2013
dc.description.abstractPrimary prevention of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) in children depends on prompt and effective diagnosis and treatment of pharyngitis at the primary level of care. Cost-effectiveness modeling shows that the most cost-effective strategy for primary prevention in South Africa (SA) is to use a simple symptomatic clinical decision rule (CDR) to diagnose pharyngitis in children presenting at the primary level of care and then to treat them with a single dose of intramuscular penicillin. Treat All and CDR2+ strategies are affordable and simple and miss few cases of streptococcal pharyngitis at the primary level of care. The CDR2+ strategy is the most cost-effective for primary prevention of ARF and RHD in urban SA and should complement primordial and secondary prevention efforts.
dc.identifier.apacitationIrlam, J. H., Mayosi, B. M., Engel, M. E., & Gaziano, T. A. (2013). A cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis. <i>South African Medical Journal</i>, 103(12), 894 - 177. http://hdl.handle.net/11427/34885en_ZA
dc.identifier.chicagocitationIrlam, James H, Bongani M Mayosi, Mark E Engel, and Thomas A Gaziano "A cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis." <i>South African Medical Journal</i> 103, 12. (2013): 894 - 177. http://hdl.handle.net/11427/34885en_ZA
dc.identifier.citationIrlam, J.H., Mayosi, B.M., Engel, M.E. & Gaziano, T.A. 2013. A cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis. <i>South African Medical Journal.</i> 103(12):894 - 177. http://hdl.handle.net/11427/34885en_ZA
dc.identifier.issn0038-2469
dc.identifier.ris TY - Journal Article AU - Irlam, James H AU - Mayosi, Bongani M AU - Engel, Mark E AU - Gaziano, Thomas A AB - Primary prevention of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) in children depends on prompt and effective diagnosis and treatment of pharyngitis at the primary level of care. Cost-effectiveness modeling shows that the most cost-effective strategy for primary prevention in South Africa (SA) is to use a simple symptomatic clinical decision rule (CDR) to diagnose pharyngitis in children presenting at the primary level of care and then to treat them with a single dose of intramuscular penicillin. Treat All and CDR2+ strategies are affordable and simple and miss few cases of streptococcal pharyngitis at the primary level of care. The CDR2+ strategy is the most cost-effective for primary prevention of ARF and RHD in urban SA and should complement primordial and secondary prevention efforts. DA - 2013 DB - OpenUCT DP - University of Cape Town IS - 12 J1 - South African Medical Journal LK - https://open.uct.ac.za PY - 2013 SM - 0038-2469 T1 - A cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis TI - A cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis UR - http://hdl.handle.net/11427/34885 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34885
dc.identifier.vancouvercitationIrlam JH, Mayosi BM, Engel ME, Gaziano TA. A cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis. South African Medical Journal. 2013;103(12):894 - 177. http://hdl.handle.net/11427/34885.en_ZA
dc.language.isoeng
dc.publisher.departmentPrimary Health Care Directorate
dc.publisher.facultyFaculty of Health Sciences
dc.sourceSouth African Medical Journal
dc.source.journalissue12
dc.source.journalvolume103
dc.source.pagination894 - 177
dc.source.urihttps://dx.doi.org/10.7196/SAMJ.7244
dc.subject.otherRheumatic Heart Disease
dc.subject.otherPharyngitis
dc.subject.otherRheumatic Fever
dc.subject.otherPenicillins
dc.subject.otherComplement System Proteins
dc.subject.otherDiagnosis
dc.subject.otherSecondary Prevention
dc.subject.otherTherapeutics
dc.subject.otherHomo sapiens
dc.subject.otherrheumatic heart disease
dc.subject.otherprimary prevention
dc.subject.othercost-effectiveness
dc.subject.otheracute rheumatic fever
dc.subject.otherWHO clinical decision rule
dc.titleA cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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