A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town

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dc.contributor.authorOni, Toluen_ZA
dc.contributor.authorTsekela, Relebohileen_ZA
dc.contributor.authorKwaza, Bekekileen_ZA
dc.contributor.authorManjezi, Lulamaen_ZA
dc.contributor.authorBangani, Nonzwakazien_ZA
dc.contributor.authorWilkinson, Katalin Aen_ZA
dc.contributor.authorCoetzee, Daviden_ZA
dc.contributor.authorWilkinson, Robert Jen_ZA
dc.date.accessioned2015-12-28T06:47:45Z
dc.date.available2015-12-28T06:47:45Z
dc.date.issued2012en_ZA
dc.description.abstractIntroduction: Despite high rates of successful treatment TB incidence in South Africa remains high, suggesting ongoing transmission and a large reservoir of latently infected persons. Isoniazid preventive therapy (IPT) is recommended as preventive therapy in HIV-infected persons. However, implementation has been slow, impeded by barriers and challenges including the fear of non-adherence. Objective and Methods: The aim was to evaluate predictors of IPT non-completion. One hundred and sixty four antiretroviral therapy (ART)-naïve HIV-infected patients with tuberculin skin test ≥5 mm were recruited from Khayelitsha day hospital and followed up monthly. A questionnaire was used to collect demographic information. Results: The overall completion rate was 69%. In multivariable analysis, there was a 29% decrease in risk of non-completion for every year after HIV diagnosis (OR 0.81; 95% C.I. 0.68–0.98). Self-reported alcohol drinkers (OR 4.05; 95% C.I. 1.89–9.06) also had a four-fold higher risk of non-completion, with a strong association between alcohol drinkers and smoking (χ2 27.08; p<0.001). Conclusion: We identify patients with a recent HIV diagnosis, in addition to self-reported drinkers and smokers as being at higher risk of non-completion of IPT. The period of time since HIV diagnosis should therefore be taken into account when initiating IPT. Our results also suggest that smokers and alcohol drinkers should be identified and targeted for adherence interventions when implementing IPT on a wider scale.en_ZA
dc.identifier.apacitationOni, T., Tsekela, R., Kwaza, B., Manjezi, L., Bangani, N., Wilkinson, K. A., ... Wilkinson, R. J. (2012). A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town. <i>PLoS One</i>, http://hdl.handle.net/11427/16048en_ZA
dc.identifier.chicagocitationOni, Tolu, Relebohile Tsekela, Bekekile Kwaza, Lulama Manjezi, Nonzwakazi Bangani, Katalin A Wilkinson, David Coetzee, and Robert J Wilkinson "A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town." <i>PLoS One</i> (2012) http://hdl.handle.net/11427/16048en_ZA
dc.identifier.citationOni, T., Tsekela, R., Kwaza, B., Manjezi, L., Bangani, N., Wilkinson, K. A., ... & Wilkinson, R. J. (2012). A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town. PLoS ONE, 7(12), e52489. doi:10.1371/journal.pone.0052489en_ZA
dc.identifier.ris TY - Journal Article AU - Oni, Tolu AU - Tsekela, Relebohile AU - Kwaza, Bekekile AU - Manjezi, Lulama AU - Bangani, Nonzwakazi AU - Wilkinson, Katalin A AU - Coetzee, David AU - Wilkinson, Robert J AB - Introduction: Despite high rates of successful treatment TB incidence in South Africa remains high, suggesting ongoing transmission and a large reservoir of latently infected persons. Isoniazid preventive therapy (IPT) is recommended as preventive therapy in HIV-infected persons. However, implementation has been slow, impeded by barriers and challenges including the fear of non-adherence. Objective and Methods: The aim was to evaluate predictors of IPT non-completion. One hundred and sixty four antiretroviral therapy (ART)-naïve HIV-infected patients with tuberculin skin test ≥5 mm were recruited from Khayelitsha day hospital and followed up monthly. A questionnaire was used to collect demographic information. Results: The overall completion rate was 69%. In multivariable analysis, there was a 29% decrease in risk of non-completion for every year after HIV diagnosis (OR 0.81; 95% C.I. 0.68–0.98). Self-reported alcohol drinkers (OR 4.05; 95% C.I. 1.89–9.06) also had a four-fold higher risk of non-completion, with a strong association between alcohol drinkers and smoking (χ2 27.08; p<0.001). Conclusion: We identify patients with a recent HIV diagnosis, in addition to self-reported drinkers and smokers as being at higher risk of non-completion of IPT. The period of time since HIV diagnosis should therefore be taken into account when initiating IPT. Our results also suggest that smokers and alcohol drinkers should be identified and targeted for adherence interventions when implementing IPT on a wider scale. DA - 2012 DB - OpenUCT DO - 10.1371/journal.pone.0052489 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town TI - A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town UR - http://hdl.handle.net/11427/16048 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16048
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0052489
dc.identifier.vancouvercitationOni T, Tsekela R, Kwaza B, Manjezi L, Bangani N, Wilkinson KA, et al. A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town. PLoS One. 2012; http://hdl.handle.net/11427/16048.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2012 Oni et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherHIV diagnosis and managementen_ZA
dc.subject.otherAlcohol consumptionen_ZA
dc.subject.otherTuberculosisen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherAntiretroviral therapyen_ZA
dc.subject.otherTuberculosis diagnosis and managementen_ZA
dc.subject.otherIsoniaziden_ZA
dc.subject.otherSouth Africaen_ZA
dc.titleA Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Townen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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