Avoidance of Protein Fold Disruption in Natural Virus Recombinants

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dc.contributor.authorLefeuvre, Pierreen_ZA
dc.contributor.authorLett, Jean-Michelen_ZA
dc.contributor.authorReynaud, Bernarden_ZA
dc.contributor.authorMartin, Darren Pen_ZA
dc.date.accessioned2015-11-09T13:17:40Z
dc.date.available2015-11-09T13:17:40Z
dc.date.issued2007en_ZA
dc.description.abstractAuthor Summary The exchange of genetic material between different virus species, called inter-species recombination, has the potential to generate, within a single genome replication cycle, an almost unimaginable number of genetically distinct virus strains, including many that might cause deadly new human, animal, or plant diseases. Many fear that inter-species recombination could provide viruses with quick access to evolutionary innovations such as broader host ranges, altered tissue tropisms, or increased severities. However, mounting evidence suggests that recombination is not an unconstrained process and that most inter-species recombinants that occur in nature are probably defective. It is suspected that networks of coevolved interactions between different parts of virus genomes and their encoded proteins must be kept intact for newly formed inter-species recombinants to have any chance of out-competing their parents. One category of coevolved interaction is that between contacting amino acids within the 3-D structures of folded proteins. Here we examine the distributions of recombination events across the genomes of a group of rampantly recombining plant viruses and find very good evidence that this class of interaction tends to be preserved amongst recombinant sequences sampled from nature. This indicates that selection against misfolded proteins strongly influences the survival of natural recombinants.en_ZA
dc.identifier.apacitationLefeuvre, P., Lett, J., Reynaud, B., & Martin, D. P. (2007). Avoidance of Protein Fold Disruption in Natural Virus Recombinants. <i>PLoS One</i>, http://hdl.handle.net/11427/14785en_ZA
dc.identifier.chicagocitationLefeuvre, Pierre, Jean-Michel Lett, Bernard Reynaud, and Darren P Martin "Avoidance of Protein Fold Disruption in Natural Virus Recombinants." <i>PLoS One</i> (2007) http://hdl.handle.net/11427/14785en_ZA
dc.identifier.citationLefeuvre, P., Lett, J. M., Reynaud, B., & Martin, D. P. (2007). Avoidance of protein fold disruption in natural virus recombinants. PLoS Pathog, 3(11), e181. doi:10.1371/journal.ppat.0030181en_ZA
dc.identifier.ris TY - Journal Article AU - Lefeuvre, Pierre AU - Lett, Jean-Michel AU - Reynaud, Bernard AU - Martin, Darren P AB - Author Summary The exchange of genetic material between different virus species, called inter-species recombination, has the potential to generate, within a single genome replication cycle, an almost unimaginable number of genetically distinct virus strains, including many that might cause deadly new human, animal, or plant diseases. Many fear that inter-species recombination could provide viruses with quick access to evolutionary innovations such as broader host ranges, altered tissue tropisms, or increased severities. However, mounting evidence suggests that recombination is not an unconstrained process and that most inter-species recombinants that occur in nature are probably defective. It is suspected that networks of coevolved interactions between different parts of virus genomes and their encoded proteins must be kept intact for newly formed inter-species recombinants to have any chance of out-competing their parents. One category of coevolved interaction is that between contacting amino acids within the 3-D structures of folded proteins. Here we examine the distributions of recombination events across the genomes of a group of rampantly recombining plant viruses and find very good evidence that this class of interaction tends to be preserved amongst recombinant sequences sampled from nature. This indicates that selection against misfolded proteins strongly influences the survival of natural recombinants. DA - 2007 DB - OpenUCT DO - 10.1371/journal.ppat.0030181 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 T1 - Avoidance of Protein Fold Disruption in Natural Virus Recombinants TI - Avoidance of Protein Fold Disruption in Natural Virus Recombinants UR - http://hdl.handle.net/11427/14785 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14785
dc.identifier.urihttp://dx.doi.org/10.1371/journal.ppat.0030181
dc.identifier.vancouvercitationLefeuvre P, Lett J, Reynaud B, Martin DP. Avoidance of Protein Fold Disruption in Natural Virus Recombinants. PLoS One. 2007; http://hdl.handle.net/11427/14785.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2007 Lefeuvre et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plospathogensen_ZA
dc.subject.otherRecombinant proteinsen_ZA
dc.subject.otherDNA recombinationen_ZA
dc.subject.otherDNA sequence analysisen_ZA
dc.subject.otherPlant genomicsen_ZA
dc.subject.otherSequence alignmenten_ZA
dc.subject.otherStructural genomicsen_ZA
dc.subject.otherViral genomicsen_ZA
dc.subject.otherGenome evolutionen_ZA
dc.titleAvoidance of Protein Fold Disruption in Natural Virus Recombinantsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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