Unexplained HIV-1 infection in children — documenting cases and assessing for possible risk factors
| dc.contributor.author | Hiemstra, R | |
| dc.contributor.author | Rabie, H | |
| dc.contributor.author | Schaaf, H S | |
| dc.contributor.author | Eley, B S | |
| dc.contributor.author | Cameron, N | |
| dc.contributor.author | Mehtar, S | |
| dc.contributor.author | Janse van Rensburg, A | |
| dc.contributor.author | Cotton, M F | |
| dc.date.accessioned | 2016-03-17T13:27:59Z | |
| dc.date.available | 2016-03-17T13:27:59Z | |
| dc.date.issued | 2004 | |
| dc.date.updated | 2016-01-18T08:03:45Z | |
| dc.description.abstract | Background. In the year 2000 we reported possible horizontal transmission of HIV-1 infection between two siblings. An investigation of three families, each with an HIV-infected child but seronegative parents, permitted this finding. Sexual abuse and surrogate breast-feeding were thought unlikely. The children had overlapping hospitalisation in a regional hospital. Since then several cases of unexplained HIV infection in children have been reported. A registry was established at Tygerberg Children’s Hospital for collection of data on the extent of horizontal or unexplained transmission of HIV in children. Study design. Retrospective chart review. Results. Fourteen children were identified, 12 from the Western Cape and 1 each from the Eastern Cape and KwaZulu-Natal. Thirteen (92%) had been hospitalised previously. In the Western Cape, children had been hospitalised in 8 hospitals. Ten of 13 (77%) were admitted as neonates and 9 of 13 (69%) had 2 or more admissions. Intravascular cannulation and intravenous drug administration occurred in all but 2 children before HIV diagnosis. Conclusion. We have confirmed HIV infection in a number of cases where the source of infection has been inadequately explained. Circumstantial evidence supports but does not prove nosocomial transmission. Further studies and identification of medical procedures conducive to the spread of HIV are urgently needed. | en_ZA |
| dc.identifier.apacitation | Hiemstra, R., Rabie, H., Schaaf, H. S., Eley, B. S., Cameron, N., Mehtar, S., ... Cotton, M. F. (2004). Unexplained HIV-1 infection in children — documenting cases and assessing for possible risk factors. <i>South African Medical Journal</i>, http://hdl.handle.net/11427/17973 | en_ZA |
| dc.identifier.chicagocitation | Hiemstra, R, H Rabie, H S Schaaf, B S Eley, N Cameron, S Mehtar, A Janse van Rensburg, and M F Cotton "Unexplained HIV-1 infection in children — documenting cases and assessing for possible risk factors." <i>South African Medical Journal</i> (2004) http://hdl.handle.net/11427/17973 | en_ZA |
| dc.identifier.citation | Hiemstra, R., Rabie, H., Schaaf, H. S., Eley, B., Cameron, N., Mehtar, S., ... & Cotton, M. F. (2004). Unexplained HIV-1 infection in children-documenting cases and assessing for possible risk factors: original article. South African Medical Journal, 94(3), p-188. | en_ZA |
| dc.identifier.issn | 0256-9574 | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - Hiemstra, R AU - Rabie, H AU - Schaaf, H S AU - Eley, B S AU - Cameron, N AU - Mehtar, S AU - Janse van Rensburg, A AU - Cotton, M F AB - Background. In the year 2000 we reported possible horizontal transmission of HIV-1 infection between two siblings. An investigation of three families, each with an HIV-infected child but seronegative parents, permitted this finding. Sexual abuse and surrogate breast-feeding were thought unlikely. The children had overlapping hospitalisation in a regional hospital. Since then several cases of unexplained HIV infection in children have been reported. A registry was established at Tygerberg Children’s Hospital for collection of data on the extent of horizontal or unexplained transmission of HIV in children. Study design. Retrospective chart review. Results. Fourteen children were identified, 12 from the Western Cape and 1 each from the Eastern Cape and KwaZulu-Natal. Thirteen (92%) had been hospitalised previously. In the Western Cape, children had been hospitalised in 8 hospitals. Ten of 13 (77%) were admitted as neonates and 9 of 13 (69%) had 2 or more admissions. Intravascular cannulation and intravenous drug administration occurred in all but 2 children before HIV diagnosis. Conclusion. We have confirmed HIV infection in a number of cases where the source of infection has been inadequately explained. Circumstantial evidence supports but does not prove nosocomial transmission. Further studies and identification of medical procedures conducive to the spread of HIV are urgently needed. DA - 2004 DB - OpenUCT DP - University of Cape Town J1 - South African Medical Journal KW - HIV-1 infection KW - children LK - https://open.uct.ac.za PB - University of Cape Town PY - 2004 SM - 0256-9574 T1 - Unexplained HIV-1 infection in children — documenting cases and assessing for possible risk factors TI - Unexplained HIV-1 infection in children — documenting cases and assessing for possible risk factors UR - http://hdl.handle.net/11427/17973 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/17973 | |
| dc.identifier.vancouvercitation | Hiemstra R, Rabie H, Schaaf HS, Eley BS, Cameron N, Mehtar S, et al. Unexplained HIV-1 infection in children — documenting cases and assessing for possible risk factors. South African Medical Journal. 2004; http://hdl.handle.net/11427/17973. | en_ZA |
| dc.language | eng | en_ZA |
| dc.publisher | HEALTH & MEDICAL PUBLISHING GROUP | en_ZA |
| dc.publisher.department | Child Health Unit | en_ZA |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.rights | Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | en_ZA |
| dc.source | South African Medical Journal | en_ZA |
| dc.source.uri | http://www.samj.org.za | |
| dc.subject | HIV-1 infection | |
| dc.subject | children | |
| dc.title | Unexplained HIV-1 infection in children — documenting cases and assessing for possible risk factors | en_ZA |
| dc.type | Journal Article | en_ZA |
| uct.subject.keywords | HIV-1 infection | en_ZA |
| uct.subject.keywords | children | en_ZA |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |