The Evolutionary Value of Recombination Is Constrained by Genome Modularity

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dc.contributor.authorMartin, Darren Pen_ZA
dc.contributor.authorWalt, Eric van deren_ZA
dc.contributor.authorPosada, Daviden_ZA
dc.contributor.authorRybicki, Edward Pen_ZA
dc.date.accessioned2015-11-09T13:17:36Z
dc.date.available2015-11-09T13:17:36Z
dc.date.issued2005en_ZA
dc.description.abstractGenetic recombination is a fundamental evolutionary mechanism promoting biological adaptation. Using engineered recombinants of the small single-stranded DNA plant virus, Maize streak virus (MSV), we experimentally demonstrate that fragments of genetic material only function optimally if they reside within genomes similar to those in which they evolved. The degree of similarity necessary for optimal functionality is correlated with the complexity of intragenomic interaction networks within which genome fragments must function. There is a striking correlation between our experimental results and the types of MSV recombinants that are detectable in nature, indicating that obligatory maintenance of intragenome interaction networks strongly constrains the evolutionary value of recombination for this virus and probably for genomes in general.en_ZA
dc.identifier.apacitationMartin, D. P., Walt, E. v. d., Posada, D., & Rybicki, E. P. (2005). The Evolutionary Value of Recombination Is Constrained by Genome Modularity. <i>PLOS Genetics</i>, http://hdl.handle.net/11427/14783en_ZA
dc.identifier.chicagocitationMartin, Darren P, Eric van der Walt, David Posada, and Edward P Rybicki "The Evolutionary Value of Recombination Is Constrained by Genome Modularity." <i>PLOS Genetics</i> (2005) http://hdl.handle.net/11427/14783en_ZA
dc.identifier.citationMartin, D. P., Van der Walt, E., Posada, D., & Rybicki, E. P. (2005). The evolutionary value of recombination is constrained by genome modularity. PLoS Genet, 1(4), e51. doi:10.1371/journal.pgen.0010051en_ZA
dc.identifier.ris TY - Journal Article AU - Martin, Darren P AU - Walt, Eric van der AU - Posada, David AU - Rybicki, Edward P AB - Genetic recombination is a fundamental evolutionary mechanism promoting biological adaptation. Using engineered recombinants of the small single-stranded DNA plant virus, Maize streak virus (MSV), we experimentally demonstrate that fragments of genetic material only function optimally if they reside within genomes similar to those in which they evolved. The degree of similarity necessary for optimal functionality is correlated with the complexity of intragenomic interaction networks within which genome fragments must function. There is a striking correlation between our experimental results and the types of MSV recombinants that are detectable in nature, indicating that obligatory maintenance of intragenome interaction networks strongly constrains the evolutionary value of recombination for this virus and probably for genomes in general. DA - 2005 DB - OpenUCT DO - 10.1371/journal.pgen.0010051 DP - University of Cape Town J1 - PLOS Genetics LK - https://open.uct.ac.za PB - University of Cape Town PY - 2005 T1 - The Evolutionary Value of Recombination Is Constrained by Genome Modularity TI - The Evolutionary Value of Recombination Is Constrained by Genome Modularity UR - http://hdl.handle.net/11427/14783 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14783
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pgen.0010051
dc.identifier.vancouvercitationMartin DP, Walt Evd, Posada D, Rybicki EP. The Evolutionary Value of Recombination Is Constrained by Genome Modularity. PLOS Genetics. 2005; http://hdl.handle.net/11427/14783.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2005 Martin et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLOS Geneticsen_ZA
dc.source.urihttp://journals.plos.org/plosgeneticsen_ZA
dc.subject.otherPlant genomicsen_ZA
dc.subject.otherViral genomicsen_ZA
dc.subject.otherDNA recombinationen_ZA
dc.subject.otherGenome evolutionen_ZA
dc.subject.otherViral evolutionen_ZA
dc.subject.otherEvolutionary geneticsen_ZA
dc.subject.otherGenome complexityen_ZA
dc.subject.otherOrganismal evolutionen_ZA
dc.titleThe Evolutionary Value of Recombination Is Constrained by Genome Modularityen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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