Community views: balancing the public health benefits of earlier antiretroviral treatment with the implications for individual patients - perspectives from the community

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dc.contributor.authorSimon, Collins
dc.contributor.authorGeffen, Nathan
dc.date.accessioned2016-05-09T10:25:07Z
dc.date.available2016-05-09T10:25:07Z
dc.date.issued2014
dc.date.updated2016-05-09T10:23:35Z
dc.description.abstractPurpose of review: When should people with HIV start treatment? This question is widely debated. The recent momentum to initiate treatment at a CD4 cell count above 350 cells/mm3 is driven by the potential population benefits of antiretroviral treatment reducing infectiousness together with operational concerns. These are important. However, we focus on the clinical benefits and risks for the person taking treatment, and how this may vary depending on the background health setting. Recent findings: We refer to the recent guideline changes and the limited evidence on which they are based. Many studies that have informed guideline changes reference plausible benefits, but have limited follow-up and are not designed to assess the potential risks. We note historical examples to show that expert opinion in the absence of data warrants caution. Summary: Results from well powered studies designed to look at the question of when to start treatment are essential for quantifying the benefits and risks of earlier treatment. Meanwhile, the decision of when to start must be taken by the HIV-positive person in consultation with their health worker based on accurate information. That choice will vary depending on a person's individual health, their reason to want to treat and the resources of the health-care facility.en_ZA
dc.identifierhttp://dx.doi.org/10.1097/COH.0000000000000024
dc.identifier.apacitationSimon, C., & Geffen, N. (2014). Community views: balancing the public health benefits of earlier antiretroviral treatment with the implications for individual patients - perspectives from the community. <i>Current Opinion in HIV and AIDS</i>, http://hdl.handle.net/11427/19528en_ZA
dc.identifier.chicagocitationSimon, Collins, and Nathan Geffen "Community views: balancing the public health benefits of earlier antiretroviral treatment with the implications for individual patients - perspectives from the community." <i>Current Opinion in HIV and AIDS</i> (2014) http://hdl.handle.net/11427/19528en_ZA
dc.identifier.citationCollins, S., & Geffen, N. (2014). Community views: balancing the public health benefits of earlier antiretroviral treatment with the implications for individual patients–perspectives from the community. Current Opinion in HIV and AIDS, 9(1), 4-10.en_ZA
dc.identifier.issn1746-630Xen_ZA
dc.identifier.ris TY - Journal Article AU - Simon, Collins AU - Geffen, Nathan AB - Purpose of review: When should people with HIV start treatment? This question is widely debated. The recent momentum to initiate treatment at a CD4 cell count above 350 cells/mm3 is driven by the potential population benefits of antiretroviral treatment reducing infectiousness together with operational concerns. These are important. However, we focus on the clinical benefits and risks for the person taking treatment, and how this may vary depending on the background health setting. Recent findings: We refer to the recent guideline changes and the limited evidence on which they are based. Many studies that have informed guideline changes reference plausible benefits, but have limited follow-up and are not designed to assess the potential risks. We note historical examples to show that expert opinion in the absence of data warrants caution. Summary: Results from well powered studies designed to look at the question of when to start treatment are essential for quantifying the benefits and risks of earlier treatment. Meanwhile, the decision of when to start must be taken by the HIV-positive person in consultation with their health worker based on accurate information. That choice will vary depending on a person's individual health, their reason to want to treat and the resources of the health-care facility. DA - 2014 DB - OpenUCT DP - University of Cape Town J1 - Current Opinion in HIV and AIDS LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 SM - 1746-630X T1 - Community views: balancing the public health benefits of earlier antiretroviral treatment with the implications for individual patients - perspectives from the community TI - Community views: balancing the public health benefits of earlier antiretroviral treatment with the implications for individual patients - perspectives from the community UR - http://hdl.handle.net/11427/19528 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/19528
dc.identifier.vancouvercitationSimon C, Geffen N. Community views: balancing the public health benefits of earlier antiretroviral treatment with the implications for individual patients - perspectives from the community. Current Opinion in HIV and AIDS. 2014; http://hdl.handle.net/11427/19528.en_ZA
dc.languageengen_ZA
dc.publisherLippincott, Williams & Wilkinsen_ZA
dc.publisher.departmentCentre for Social Science Research(CSSR)en_ZA
dc.publisher.facultyFaculty of Humanitiesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceCurrent Opinion in HIV and AIDSen_ZA
dc.source.urihttp://journals.lww.com/co-hivandaids/Pages/default.aspx
dc.titleCommunity views: balancing the public health benefits of earlier antiretroviral treatment with the implications for individual patients - perspectives from the communityen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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