Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series

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dc.contributor.advisorTinley, Christopher
dc.contributor.authorVan der Merwe, Pieter Jacobus Stephanus
dc.date.accessioned2022-03-22T10:36:17Z
dc.date.available2022-03-22T10:36:17Z
dc.date.issued2021
dc.date.updated2022-03-22T07:08:52Z
dc.description.abstractBackground: Ethambutol hydrochloride and linezolid are commonly used anti-tuberculous agents. Both agents can cause potentially blinding toxic optic neuropathy. Currently there is no low-cost, sensitive screening tool to detect early toxicity before permanent vision loss has occurred. Purpose: To evaluate the ability of the Adams D-15 colour vision test to detect early ethambutol- and linezolid-induced optic neuropathy. Methods: This was a retrospective case series of 15 patients who were screened for ethambutol- and linezolid-induced toxic optic neuropathy. At screening and follow-up visits, a detailed clinical history was taken, a standard of care examination performed and a battery of side-room investigations conducted, including: Farnsworth Munsell D15 (FM D15) and Adams D15 colour vision tests, retinal nerve fiber layer optical coherence tomography (RNFL-OCT) and a Humphrey visual field 24-2 (HVF 24-2). According to the results of these tests, the patients were classified into 3 groups: “No toxicity”, “Uncertain toxicity” or “Confirmed toxicity”. Results: Six patients were classified as “No toxicity”, 3 were “Uncertain toxicity” and 6 were classified as “Confirmed toxicity”. The Adams D15 showed a sensitivity of 100% for detecting a toxic optic neuropathy. Conclusion: The Adams D15 is a sensitive screening tool for the detection of early ethambutol- and linezolid-induced optic neuropathy.
dc.identifier.apacitationVan der Merwe, P. J. S. (2021). <i>Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series</i>. (). ,Faculty of Health Sciences ,Division of General Surgery. Retrieved from http://hdl.handle.net/11427/36200en_ZA
dc.identifier.chicagocitationVan der Merwe, Pieter Jacobus Stephanus. <i>"Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series."</i> ., ,Faculty of Health Sciences ,Division of General Surgery, 2021. http://hdl.handle.net/11427/36200en_ZA
dc.identifier.citationVan der Merwe, P.J.S. 2021. Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series. . ,Faculty of Health Sciences ,Division of General Surgery. http://hdl.handle.net/11427/36200en_ZA
dc.identifier.ris TY - Master Thesis AU - Van der Merwe, Pieter Jacobus Stephanus AB - Background: Ethambutol hydrochloride and linezolid are commonly used anti-tuberculous agents. Both agents can cause potentially blinding toxic optic neuropathy. Currently there is no low-cost, sensitive screening tool to detect early toxicity before permanent vision loss has occurred. Purpose: To evaluate the ability of the Adams D-15 colour vision test to detect early ethambutol- and linezolid-induced optic neuropathy. Methods: This was a retrospective case series of 15 patients who were screened for ethambutol- and linezolid-induced toxic optic neuropathy. At screening and follow-up visits, a detailed clinical history was taken, a standard of care examination performed and a battery of side-room investigations conducted, including: Farnsworth Munsell D15 (FM D15) and Adams D15 colour vision tests, retinal nerve fiber layer optical coherence tomography (RNFL-OCT) and a Humphrey visual field 24-2 (HVF 24-2). According to the results of these tests, the patients were classified into 3 groups: “No toxicity”, “Uncertain toxicity” or “Confirmed toxicity”. Results: Six patients were classified as “No toxicity”, 3 were “Uncertain toxicity” and 6 were classified as “Confirmed toxicity”. The Adams D15 showed a sensitivity of 100% for detecting a toxic optic neuropathy. Conclusion: The Adams D15 is a sensitive screening tool for the detection of early ethambutol- and linezolid-induced optic neuropathy. DA - 2021_ DB - OpenUCT DP - University of Cape Town KW - Ophthalmology LK - https://open.uct.ac.za PY - 2021 T1 - Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series TI - Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series UR - http://hdl.handle.net/11427/36200 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/36200
dc.identifier.vancouvercitationVan der Merwe PJS. Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series. []. ,Faculty of Health Sciences ,Division of General Surgery, 2021 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/36200en_ZA
dc.language.rfc3066eng
dc.publisher.departmentDivision of General Surgery
dc.publisher.facultyFaculty of Health Sciences
dc.subjectOphthalmology
dc.titleIs the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationlevelMMed
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