TB incidence in an adolescent cohort in South Africa

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dc.contributor.authorMahomed, Hassanen_ZA
dc.contributor.authorEhrlich, Rodneyen_ZA
dc.contributor.authorHawkridge, Tonyen_ZA
dc.contributor.authorHatherill, Marken_ZA
dc.contributor.authorGeiter, Lawrenceen_ZA
dc.contributor.authorKafaar, Fazlinen_ZA
dc.contributor.authorAbrahams, Deborah Annen_ZA
dc.contributor.authorMulenga, Humphreyen_ZA
dc.contributor.authorTameris, Micheleen_ZA
dc.contributor.authorGeldenhuys, Hennieen_ZA
dc.date.accessioned2016-01-02T05:08:39Z
dc.date.available2016-01-02T05:08:39Z
dc.date.issued2013en_ZA
dc.description.abstractBACKGROUND: Tuberculosis (TB) is a major public health problem globally. Little is known about TB incidence in adolescents who are a proposed target group for new TB vaccines. We conducted a study to determine the TB incidence rates and risk factors for TB disease in a cohort of school-going adolescents in a high TB burden area in South Africa. METHODS: We recruited adolescents aged 12 to 18 years from high schools in Worcester, South Africa. Demographic and clinical information was collected, a tuberculin skin test (TST) performed and blood drawn for a QuantiFERON TB Gold assay at baseline. Screening for TB cases occurred at follow up visits and by surveillance of registers at public sector TB clinics over a period of up to 3.8 years after enrolment. RESULTS: A total of 6,363 adolescents were enrolled (58% of the school population targeted). During follow up, 67 cases of bacteriologically confirmed TB were detected giving an overall incidence rate of 0.45 per 100 person years (95% confidence interval 0.29-0.72). Black or mixed race, maternal education of primary school or less or unknown, a positive baseline QuantiFERON assay and a positive baseline TST were significant predictors of TB disease on adjusted analysis. CONCLUSION: The adolescent TB incidence found in a high burden setting will help TB vaccine developers plan clinical trials in this population. Latent TB infection and low socio-economic status were predictors of TB disease.en_ZA
dc.identifier.apacitationMahomed, H., Ehrlich, R., Hawkridge, T., Hatherill, M., Geiter, L., Kafaar, F., ... Geldenhuys, H. (2013). TB incidence in an adolescent cohort in South Africa. <i>PLoS One</i>, http://hdl.handle.net/11427/16185en_ZA
dc.identifier.chicagocitationMahomed, Hassan, Rodney Ehrlich, Tony Hawkridge, Mark Hatherill, Lawrence Geiter, Fazlin Kafaar, Deborah Ann Abrahams, Humphrey Mulenga, Michele Tameris, and Hennie Geldenhuys "TB incidence in an adolescent cohort in South Africa." <i>PLoS One</i> (2013) http://hdl.handle.net/11427/16185en_ZA
dc.identifier.citationMahomed, H., Ehrlich, R., Hawkridge, T., Hatherill, M., Geiter, L., Kafaar, F., ... & Hussey, G. D. (2013). TB incidence in an adolescent cohort in South Africa. PLoS One, 8(3), e59652. doi:10.1371/journal.pone.0059652en_ZA
dc.identifier.ris TY - Journal Article AU - Mahomed, Hassan AU - Ehrlich, Rodney AU - Hawkridge, Tony AU - Hatherill, Mark AU - Geiter, Lawrence AU - Kafaar, Fazlin AU - Abrahams, Deborah Ann AU - Mulenga, Humphrey AU - Tameris, Michele AU - Geldenhuys, Hennie AB - BACKGROUND: Tuberculosis (TB) is a major public health problem globally. Little is known about TB incidence in adolescents who are a proposed target group for new TB vaccines. We conducted a study to determine the TB incidence rates and risk factors for TB disease in a cohort of school-going adolescents in a high TB burden area in South Africa. METHODS: We recruited adolescents aged 12 to 18 years from high schools in Worcester, South Africa. Demographic and clinical information was collected, a tuberculin skin test (TST) performed and blood drawn for a QuantiFERON TB Gold assay at baseline. Screening for TB cases occurred at follow up visits and by surveillance of registers at public sector TB clinics over a period of up to 3.8 years after enrolment. RESULTS: A total of 6,363 adolescents were enrolled (58% of the school population targeted). During follow up, 67 cases of bacteriologically confirmed TB were detected giving an overall incidence rate of 0.45 per 100 person years (95% confidence interval 0.29-0.72). Black or mixed race, maternal education of primary school or less or unknown, a positive baseline QuantiFERON assay and a positive baseline TST were significant predictors of TB disease on adjusted analysis. CONCLUSION: The adolescent TB incidence found in a high burden setting will help TB vaccine developers plan clinical trials in this population. Latent TB infection and low socio-economic status were predictors of TB disease. DA - 2013 DB - OpenUCT DO - 10.1371/journal.pone.0059652 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - TB incidence in an adolescent cohort in South Africa TI - TB incidence in an adolescent cohort in South Africa UR - http://hdl.handle.net/11427/16185 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16185
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0059652
dc.identifier.vancouvercitationMahomed H, Ehrlich R, Hawkridge T, Hatherill M, Geiter L, Kafaar F, et al. TB incidence in an adolescent cohort in South Africa. PLoS One. 2013; http://hdl.handle.net/11427/16185.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2013 Mahomed et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherTuberculosisen_ZA
dc.subject.otherAdolescentsen_ZA
dc.subject.otherSchoolsen_ZA
dc.subject.otherTuberculosis diagnosis and managementen_ZA
dc.subject.otherSouth Africaen_ZA
dc.subject.otherVaccinesen_ZA
dc.subject.otherConfidence intervalsen_ZA
dc.subject.otherHealth risk analysisen_ZA
dc.titleTB incidence in an adolescent cohort in South Africaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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