Cohort Profile: The Western Cape Pregnancy Exposure Registry (WCPER)

Simple item page
dc.contributor.authorKalk, Emma
dc.contributor.authorHeekes, Alexa
dc.contributor.authorSlogrove, Amy
dc.contributor.authorPhelanyane, Florence
dc.contributor.authorDavies, Mary-Ann
dc.contributor.authorMyer, Landon
dc.contributor.authorEuvrard, Jonathan
dc.contributor.authorKroon, Max
dc.contributor.authorPetro, Greg
dc.contributor.authorFieggen, Karen
dc.contributor.authorStewart, Chantal
dc.contributor.authorRhoda, Natasha
dc.contributor.authorGebhardt, Stefan
dc.contributor.authorOsman, Ayesha
dc.contributor.authorAnderson, Kim
dc.contributor.authorBoulle, Andrew
dc.contributor.authorMehta, Ushma
dc.date.accessioned2022-07-27T12:56:23Z
dc.date.available2022-07-27T12:56:23Z
dc.date.issued2022-06
dc.description.abstractPurpose: The Western Cape Pregnancy Exposure Registry (PER) was established at two public sector healthcare sentinel sites in the Western Cape province, South Africa, to provide ongoing surveillance of drug exposures in pregnancy and associations with pregnancy outcomes. Participants: Established in 2016, all women attending their first antenatal visit at primary care obstetric facilities were enrolled and followed to pregnancy outcome regardless of the site (ie, primary, secondary, tertiary facility). Routine operational obstetric and medical data are digitised from the clinical stationery at the healthcare facilities. Data collection has been integrated into existing services and information platforms and supports routine operations. The PER is situated within the Provincial Health Data Centre, an information exchange that harmonises and consolidates all health-related electronic data in the province. Data are contributed via linkage across a unique identifier. This relationship limits the missing data in the PER, allows validation and avoids misclassification in the population-level data set. Findings to date: Approximately 5000 and 3500 pregnant women enter the data set annually at the urban and rural sites, respectively. As of August 2021, >30 000 pregnancies have been recorded and outcomes have been determined for 93%. Analysis of key obstetric and neonatal health indicators derived from the PER are consistent with the aggregate data in the District Health Information System. Future plans: This represents significant infrastructure, able to address clinical and epidemiological concerns in a low/middle-income setting.en_US
dc.identifier.apacitationKalk, E., Heekes, A., Slogrove, A., Phelanyane, F., Davies, M., Myer, L., ... Mehta, U. (2022). Cohort Profile: The Western Cape Pregnancy Exposure Registry (WCPER). <i>BMJ Open</i>, 12 http://hdl.handle.net/11427/36659en_ZA
dc.identifier.chicagocitationKalk, Emma, Alexa Heekes, Amy Slogrove, Florence Phelanyane, Mary-Ann Davies, Landon Myer, Jonathan Euvrard, et al "Cohort Profile: The Western Cape Pregnancy Exposure Registry (WCPER)." <i>BMJ Open</i> 12, (2022) http://hdl.handle.net/11427/36659en_ZA
dc.identifier.citationKalk, E., Heekes, A., Slogrove, A., Phelanyane, F., Davies, M., Myer, L., Euvrard, J. & Kroon, M. et al. 2022. Cohort Profile: The Western Cape Pregnancy Exposure Registry (WCPER). <i>BMJ Open.</i> 12 http://hdl.handle.net/11427/36659en_ZA
dc.identifier.ris TY - Journal Article AU - Kalk, Emma AU - Heekes, Alexa AU - Slogrove, Amy AU - Phelanyane, Florence AU - Davies, Mary-Ann AU - Myer, Landon AU - Euvrard, Jonathan AU - Kroon, Max AU - Petro, Greg AU - Fieggen, Karen AU - Stewart, Chantal AU - Rhoda, Natasha AU - Gebhardt, Stefan AU - Osman, Ayesha AU - Anderson, Kim AU - Boulle, Andrew AU - Mehta, Ushma AB - Purpose: The Western Cape Pregnancy Exposure Registry (PER) was established at two public sector healthcare sentinel sites in the Western Cape province, South Africa, to provide ongoing surveillance of drug exposures in pregnancy and associations with pregnancy outcomes. Participants: Established in 2016, all women attending their first antenatal visit at primary care obstetric facilities were enrolled and followed to pregnancy outcome regardless of the site (ie, primary, secondary, tertiary facility). Routine operational obstetric and medical data are digitised from the clinical stationery at the healthcare facilities. Data collection has been integrated into existing services and information platforms and supports routine operations. The PER is situated within the Provincial Health Data Centre, an information exchange that harmonises and consolidates all health-related electronic data in the province. Data are contributed via linkage across a unique identifier. This relationship limits the missing data in the PER, allows validation and avoids misclassification in the population-level data set. Findings to date: Approximately 5000 and 3500 pregnant women enter the data set annually at the urban and rural sites, respectively. As of August 2021, >30 000 pregnancies have been recorded and outcomes have been determined for 93%. Analysis of key obstetric and neonatal health indicators derived from the PER are consistent with the aggregate data in the District Health Information System. Future plans: This represents significant infrastructure, able to address clinical and epidemiological concerns in a low/middle-income setting. DA - 2022-06 DB - OpenUCT DP - University of Cape Town J1 - BMJ Open KW - Pregnancy Exposure Registry; Western cape LK - https://open.uct.ac.za PY - 2022 T1 - Cohort Profile: The Western Cape Pregnancy Exposure Registry (WCPER) TI - Cohort Profile: The Western Cape Pregnancy Exposure Registry (WCPER) UR - http://hdl.handle.net/11427/36659 ER - en_ZA
dc.identifier.uri10.1136/ bmjopen-2021-060205
dc.identifier.urihttp://hdl.handle.net/11427/36659
dc.identifier.vancouvercitationKalk E, Heekes A, Slogrove A, Phelanyane F, Davies M, Myer L, et al. Cohort Profile: The Western Cape Pregnancy Exposure Registry (WCPER). BMJ Open. 2022;12 http://hdl.handle.net/11427/36659.en_ZA
dc.language.isoenen_US
dc.publisher.departmentCentre for Infectious Disease Epidemiology and Research (CIDER)en_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceBMJ Openen_US
dc.source.journalvolume12en_US
dc.source.urihttps://bmjopen.bmj.com/
dc.subjectPregnancy Exposure Registry; Western capeen_US
dc.titleCohort Profile: The Western Cape Pregnancy Exposure Registry (WCPER)en_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Kalk_BMJOpen2022.pdf
Size:
346.33 KB
Format:
Adobe Portable Document Format
Description:
Main Article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.72 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles