Association of serum leptin and adiponectin with anthropomorphic indices of obesity, blood lipids and insulin resistance in a Sub-Saharan African population

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dc.contributor.authorAyina, Clarisse Noël A
dc.contributor.authorNoubiap, Jean Jacques N
dc.contributor.authorEtoundi Ngoa, Laurent Serge
dc.contributor.authorBoudou, Philippe
dc.contributor.authorGautier, Jean François
dc.contributor.authorMengnjo, Michel Karngong
dc.contributor.authorMbanya, Jean Claude
dc.contributor.authorSobngwi, Eugène
dc.date.accessioned2021-10-08T07:08:18Z
dc.date.available2021-10-08T07:08:18Z
dc.date.issued2016
dc.description.abstractAbstract Background There is little data on the metabolic effects of adipokines in sub-Saharan African populations. This study aimed to explore the potential relationship of leptin and adiponectin, with obesity, plasma lipids and insulin resistance in a Cameroonian population. Methods We enrolled 167 men and 309 women aged ≥18 years from the general population in Cameroon. Data were collected on waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), body fat (BF%), fasting blood glucose, plasma lipids, adiponectin, leptin, insulin and homeostasis model for assessment of insulin resistance (HOMA-IR). Pearson’s correlation and multiple stepwise linear regression analyses were used to determine correlates of leptin and adiponectin serum levels. Results The prevalence of obesity was higher in women compared to men (p < 0.0001), and Central obesity which is more prevalent particularly in women (WC = 42.4 %, WHR = 42.3 %), is almost for 90 % comparable to %BF (42.7 %). Adiponectin negatively with BMI (r = −0.294, p < 0.0001), WC (r = −0.294, p < 0.0001), %BF (r = −0.122, p = 0.028), WHR (r = −0.143, p = 0.009), triglycerides (r = −0.141, p = 0.011), HOMA-IR (r = −0.145, p = 0.027) and insulin (r = −0.130, p = 0.048). Leptin positively correlated with BMI (r = 0.628), WC (r = 0.530), BF% (r = 0.720), (all p < 0.0001); with DBP (r = 0.112, p = 0.043), total cholesterol (r = 0.324, p < 0.0001), LDL-cholesterol (r = 0.298, p < 0.0001), insulin (r = 0.320, p < 0.001 and HOMA-IR (r = 0.272, p < 0.0001). In multiple stepwise regression analysis, adiponectin was negatively associated with WC (β = −0.38, p = 0.001) and BF% (β = 0.33, p < 0.0001), while leptin was positively associated with BF% (β = 0.60, p < 0.0001), total cholesterol (β = 0.11, p = 0.02) and HOMA-IR (β = 0.11, p = 0.02). When controlled for gender, HOMA-IR was found significantly associated to adiponectin (β = 0.13, p = 0.046), but not BF%, while the association previously found between leptin and HOMA-IR disappeared; BMI and WC were significantly associated with leptin (β = 0.18, p = 0.04 & β = 0.19, p = 0.02 respectively). Conclusion This study, which includes a population who was not receiving potentially confounding medications, confirms the associations previously observed of adiponectin with reduced adiposity especially central adiposity and improved insulin sensitivity. Confirmatory associations were also observed between leptin and obesity, blood lipids and insulin resistance for the first time in an African population. Gender was significant covariate interacting with insulin sensitivity/insulin resistance and obesity indexes associations in this population.
dc.identifier.apacitationAyina, C. N. A., Noubiap, J. J. N., Etoundi Ngoa, L. S., Boudou, P., Gautier, J. F., Mengnjo, M. K., ... Sobngwi, E. (2016). Association of serum leptin and adiponectin with anthropomorphic indices of obesity, blood lipids and insulin resistance in a Sub-Saharan African population. <i>Lipids in Health and Disease</i>, 15(1), 174 - 177. http://hdl.handle.net/11427/34549en_ZA
dc.identifier.chicagocitationAyina, Clarisse Noël A, Jean Jacques N Noubiap, Laurent Serge Etoundi Ngoa, Philippe Boudou, Jean François Gautier, Michel Karngong Mengnjo, Jean Claude Mbanya, and Eugène Sobngwi "Association of serum leptin and adiponectin with anthropomorphic indices of obesity, blood lipids and insulin resistance in a Sub-Saharan African population." <i>Lipids in Health and Disease</i> 15, 1. (2016): 174 - 177. http://hdl.handle.net/11427/34549en_ZA
dc.identifier.citationAyina, C.N.A., Noubiap, J.J.N., Etoundi Ngoa, L.S., Boudou, P., Gautier, J.F., Mengnjo, M.K., Mbanya, J.C. & Sobngwi, E. et al. 2016. Association of serum leptin and adiponectin with anthropomorphic indices of obesity, blood lipids and insulin resistance in a Sub-Saharan African population. <i>Lipids in Health and Disease.</i> 15(1):174 - 177. http://hdl.handle.net/11427/34549en_ZA
dc.identifier.issn1476-511X
dc.identifier.ris TY - Journal Article AU - Ayina, Clarisse Noël A AU - Noubiap, Jean Jacques N AU - Etoundi Ngoa, Laurent Serge AU - Boudou, Philippe AU - Gautier, Jean François AU - Mengnjo, Michel Karngong AU - Mbanya, Jean Claude AU - Sobngwi, Eugène AB - Abstract Background There is little data on the metabolic effects of adipokines in sub-Saharan African populations. This study aimed to explore the potential relationship of leptin and adiponectin, with obesity, plasma lipids and insulin resistance in a Cameroonian population. Methods We enrolled 167 men and 309 women aged ≥18 years from the general population in Cameroon. Data were collected on waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), body fat (BF%), fasting blood glucose, plasma lipids, adiponectin, leptin, insulin and homeostasis model for assessment of insulin resistance (HOMA-IR). Pearson’s correlation and multiple stepwise linear regression analyses were used to determine correlates of leptin and adiponectin serum levels. Results The prevalence of obesity was higher in women compared to men (p < 0.0001), and Central obesity which is more prevalent particularly in women (WC = 42.4 %, WHR = 42.3 %), is almost for 90 % comparable to %BF (42.7 %). Adiponectin negatively with BMI (r = −0.294, p < 0.0001), WC (r = −0.294, p < 0.0001), %BF (r = −0.122, p = 0.028), WHR (r = −0.143, p = 0.009), triglycerides (r = −0.141, p = 0.011), HOMA-IR (r = −0.145, p = 0.027) and insulin (r = −0.130, p = 0.048). Leptin positively correlated with BMI (r = 0.628), WC (r = 0.530), BF% (r = 0.720), (all p < 0.0001); with DBP (r = 0.112, p = 0.043), total cholesterol (r = 0.324, p < 0.0001), LDL-cholesterol (r = 0.298, p < 0.0001), insulin (r = 0.320, p < 0.001 and HOMA-IR (r = 0.272, p < 0.0001). In multiple stepwise regression analysis, adiponectin was negatively associated with WC (β = −0.38, p = 0.001) and BF% (β = 0.33, p < 0.0001), while leptin was positively associated with BF% (β = 0.60, p < 0.0001), total cholesterol (β = 0.11, p = 0.02) and HOMA-IR (β = 0.11, p = 0.02). When controlled for gender, HOMA-IR was found significantly associated to adiponectin (β = 0.13, p = 0.046), but not BF%, while the association previously found between leptin and HOMA-IR disappeared; BMI and WC were significantly associated with leptin (β = 0.18, p = 0.04 & β = 0.19, p = 0.02 respectively). Conclusion This study, which includes a population who was not receiving potentially confounding medications, confirms the associations previously observed of adiponectin with reduced adiposity especially central adiposity and improved insulin sensitivity. Confirmatory associations were also observed between leptin and obesity, blood lipids and insulin resistance for the first time in an African population. Gender was significant covariate interacting with insulin sensitivity/insulin resistance and obesity indexes associations in this population. DA - 2016 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Lipids in Health and Disease LK - https://open.uct.ac.za PY - 2016 SM - 1476-511X T1 - Association of serum leptin and adiponectin with anthropomorphic indices of obesity, blood lipids and insulin resistance in a Sub-Saharan African population TI - Association of serum leptin and adiponectin with anthropomorphic indices of obesity, blood lipids and insulin resistance in a Sub-Saharan African population UR - http://hdl.handle.net/11427/34549 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34549
dc.identifier.vancouvercitationAyina CNA, Noubiap JJN, Etoundi Ngoa LS, Boudou P, Gautier JF, Mengnjo MK, et al. Association of serum leptin and adiponectin with anthropomorphic indices of obesity, blood lipids and insulin resistance in a Sub-Saharan African population. Lipids in Health and Disease. 2016;15(1):174 - 177. http://hdl.handle.net/11427/34549.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceLipids in Health and Disease
dc.source.journalissue1
dc.source.journalvolume15
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1186/s12944-016-0264-x
dc.subject.otherObesity
dc.subject.otherInsulin Resistance
dc.subject.otherObesity, Abdominal
dc.subject.otherSerum
dc.subject.otherBlood
dc.subject.otherPlasma
dc.subject.otherFat Body
dc.subject.otherAdipokines
dc.subject.otherLipids
dc.subject.otherInsulin
dc.subject.otherTriglycerides
dc.subject.otherCholesterol, LDL
dc.subject.otherCholesterol
dc.subject.otherAdiponectin
dc.subject.otherBlood Glucose
dc.subject.otherLeptin
dc.subject.otherHomeostasis
dc.subject.otherFasting
dc.subject.otherBody Mass Index
dc.subject.otherPrevalence
dc.subject.otherWaist Circumference
dc.subject.otherRegression Analysis
dc.subject.otherWaist-Hip Ratio
dc.subject.otherAdiposity
dc.subject.otherHomo sapiens
dc.subject.otherLipidology
dc.subject.otherMedical Biochemistry
dc.titleAssociation of serum leptin and adiponectin with anthropomorphic indices of obesity, blood lipids and insulin resistance in a Sub-Saharan African population
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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