The short-term effects of off-pump cardiopulmonary bypass graft surgery on cognitive performance

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dc.contributor.authorPursch, Lindsay Janeen_ZA
dc.date.accessioned2014-12-31T19:56:24Z
dc.date.available2014-12-31T19:56:24Z
dc.date.issued2008en_ZA
dc.descriptionIncludes bibliographical references (leaves 56-67).en_ZA
dc.description.abstractPostoperative neurocognitive impairment has been associated with coronary artery bypass graft surgery (CABG). This study investigates the short-term effects of off-pump cardiopulmonary bypass graft surgery (OPCAB) on cognitive performance, as a possible safer alternative in the treatment of coronary artery disease. This research forms part of a larger study in which, in addition to the OPCAB procedure, the cognitive effects of CABG surgery and percutaneous transluminal coronary angioplasty with intra-coronary stenting are assessed. 36 participants undergoing OPCAB surgery were included in the study, with a further 36 participants included as an age- and education- matched non-surgical control group. A standardized battery of neuropsychological tests, designed to assess seven cognitive domains, was administered on two occasions, preoperatively at 1-2 days prior to surgery, and postoperatively at 1 month after surgery, with control participant assessments at the same intervals. Emotional state scales assessing depression and anxiety levels were administered at each assessment. Data analysis included a two-way mixed analysis of variance conducted on each measure of cognitive function, and on the indicators of emotional state. In addition, standard multiple regression was conducted to assess whether change in emotional state is able to predict change in any of the cognitive domains. Results indicated no evidence of short-term cognitive decline, and highlighted an improvement in cognitive performance in both surgical and control groups in the domain of language, psychomotor speed, executive function and visual memory, with the control group demonstrating a consistently superior performance. This counter-intuitive finding could not be attributed to practice effects.en_ZA
dc.identifier.apacitationPursch, L. J. (2008). <i>The short-term effects of off-pump cardiopulmonary bypass graft surgery on cognitive performance</i>. (Thesis). University of Cape Town ,Faculty of Humanities ,Department of Psychology. Retrieved from http://hdl.handle.net/11427/10772en_ZA
dc.identifier.chicagocitationPursch, Lindsay Jane. <i>"The short-term effects of off-pump cardiopulmonary bypass graft surgery on cognitive performance."</i> Thesis., University of Cape Town ,Faculty of Humanities ,Department of Psychology, 2008. http://hdl.handle.net/11427/10772en_ZA
dc.identifier.citationPursch, L. 2008. The short-term effects of off-pump cardiopulmonary bypass graft surgery on cognitive performance. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Pursch, Lindsay Jane AB - Postoperative neurocognitive impairment has been associated with coronary artery bypass graft surgery (CABG). This study investigates the short-term effects of off-pump cardiopulmonary bypass graft surgery (OPCAB) on cognitive performance, as a possible safer alternative in the treatment of coronary artery disease. This research forms part of a larger study in which, in addition to the OPCAB procedure, the cognitive effects of CABG surgery and percutaneous transluminal coronary angioplasty with intra-coronary stenting are assessed. 36 participants undergoing OPCAB surgery were included in the study, with a further 36 participants included as an age- and education- matched non-surgical control group. A standardized battery of neuropsychological tests, designed to assess seven cognitive domains, was administered on two occasions, preoperatively at 1-2 days prior to surgery, and postoperatively at 1 month after surgery, with control participant assessments at the same intervals. Emotional state scales assessing depression and anxiety levels were administered at each assessment. Data analysis included a two-way mixed analysis of variance conducted on each measure of cognitive function, and on the indicators of emotional state. In addition, standard multiple regression was conducted to assess whether change in emotional state is able to predict change in any of the cognitive domains. Results indicated no evidence of short-term cognitive decline, and highlighted an improvement in cognitive performance in both surgical and control groups in the domain of language, psychomotor speed, executive function and visual memory, with the control group demonstrating a consistently superior performance. This counter-intuitive finding could not be attributed to practice effects. DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - The short-term effects of off-pump cardiopulmonary bypass graft surgery on cognitive performance TI - The short-term effects of off-pump cardiopulmonary bypass graft surgery on cognitive performance UR - http://hdl.handle.net/11427/10772 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/10772
dc.identifier.vancouvercitationPursch LJ. The short-term effects of off-pump cardiopulmonary bypass graft surgery on cognitive performance. [Thesis]. University of Cape Town ,Faculty of Humanities ,Department of Psychology, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/10772en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Psychologyen_ZA
dc.publisher.facultyFaculty of Humanitiesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPsychological Researchen_ZA
dc.titleThe short-term effects of off-pump cardiopulmonary bypass graft surgery on cognitive performanceen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMAen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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