Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores

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dc.contributor.advisorChibale, Kellyen_ZA
dc.contributor.authorNair, Shankarien_ZA
dc.date.accessioned2014-11-28T09:53:50Z
dc.date.available2014-11-28T09:53:50Z
dc.date.issued2012en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractMalaria stills remains one of the leading causes of death in sub-Saharan Africa, with P. falciparum being the most virulent strain of Plasmodium. Due to the emergence of drug resistance, new antimalarial agents are needed to circumvent this. Similarly, in the treatment of cancer, there is an urgent need for the design and development of new antineoplastic agents. This work describes the design, synthesis and biological evaluation of chromone-aminoquinoline hybrids as potentially new chemotherapeutic agents.en_ZA
dc.identifier.apacitationNair, S. (2012). <i>Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/9805en_ZA
dc.identifier.chicagocitationNair, Shankari. <i>"Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2012. http://hdl.handle.net/11427/9805en_ZA
dc.identifier.citationNair, S. 2012. Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Nair, Shankari AB - Malaria stills remains one of the leading causes of death in sub-Saharan Africa, with P. falciparum being the most virulent strain of Plasmodium. Due to the emergence of drug resistance, new antimalarial agents are needed to circumvent this. Similarly, in the treatment of cancer, there is an urgent need for the design and development of new antineoplastic agents. This work describes the design, synthesis and biological evaluation of chromone-aminoquinoline hybrids as potentially new chemotherapeutic agents. DA - 2012 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores TI - Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores UR - http://hdl.handle.net/11427/9805 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9805
dc.identifier.vancouvercitationNair S. Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2012 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9805en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleSynthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophoresen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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