Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africa

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dc.contributor.authorNaidoo, Reenéen_ZA
dc.contributor.authorNuttall, Jamesen_ZA
dc.contributor.authorWhitelaw, Andrewen_ZA
dc.contributor.authorEley, Brianen_ZA
dc.date.accessioned2016-01-11T06:53:21Z
dc.date.available2016-01-11T06:53:21Z
dc.date.issued2013en_ZA
dc.description.abstractBACKGROUND: Staphylococcus aureus is an important pathogen in paediatric patients with bloodstream infections. The epidemiology of S. aureus bacteraemia, however, has not been well documented in children in South Africa. METHODS: A retrospective study was conducted at a children's hospital in Cape Town, South Africa, to investigate the epidemiology of S. aureus bacteraemia from 2007-2011. The incidence, clinical presentation, risk factors, management and outcomes of methicillin sensitive S. aureus (MSSA) and methicillin resistant S. aureus (MRSA) bacteraemia were compared. RESULTS: Over the five year study period, 365 episodes of S. aureus bacteraemia were identified. The annual incidence was 3.28 cases per 1000 hospital admissions. MRSA was responsible for 26% of S. aureus bacteraemia and 72% of nosocomial infections. Only six possible cases of community-acquired MRSA infections were described. MSSA bacteraemia was more likely to present as pulmonary and bone or joint infections, while bacteraemia without a source was the most common presentation with MRSA.  Infants, children with malnutrition, and residents of long-term care facilities were at highest risk for MRSA bacteraemia. The overall case fatality rate for S. aureus bacteraemia was 8.8% over five years, with MRSA being the only significant risk factor for mortality. CONCLUSION: The incidence of S. aureus bacteraemia and MRSA bacteraemia in children has remained stable over the past five years. MRSA is a predominantly nosocomial pathogen in children with S. aureus bacteraemia in Cape Town, South Africa.en_ZA
dc.identifier.apacitationNaidoo, R., Nuttall, J., Whitelaw, A., & Eley, B. (2013). Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africa. <i>PLoS One</i>, http://hdl.handle.net/11427/16270en_ZA
dc.identifier.chicagocitationNaidoo, Reené, James Nuttall, Andrew Whitelaw, and Brian Eley "Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africa." <i>PLoS One</i> (2013) http://hdl.handle.net/11427/16270en_ZA
dc.identifier.citationNaidoo, R., Nuttall, J., Whitelaw, A., & Eley, B. (2013). Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africa. PLoS ONE, 8(10), e78396. doi:10.1371/journal.pone.0078396en_ZA
dc.identifier.ris TY - Journal Article AU - Naidoo, Reené AU - Nuttall, James AU - Whitelaw, Andrew AU - Eley, Brian AB - BACKGROUND: Staphylococcus aureus is an important pathogen in paediatric patients with bloodstream infections. The epidemiology of S. aureus bacteraemia, however, has not been well documented in children in South Africa. METHODS: A retrospective study was conducted at a children's hospital in Cape Town, South Africa, to investigate the epidemiology of S. aureus bacteraemia from 2007-2011. The incidence, clinical presentation, risk factors, management and outcomes of methicillin sensitive S. aureus (MSSA) and methicillin resistant S. aureus (MRSA) bacteraemia were compared. RESULTS: Over the five year study period, 365 episodes of S. aureus bacteraemia were identified. The annual incidence was 3.28 cases per 1000 hospital admissions. MRSA was responsible for 26% of S. aureus bacteraemia and 72% of nosocomial infections. Only six possible cases of community-acquired MRSA infections were described. MSSA bacteraemia was more likely to present as pulmonary and bone or joint infections, while bacteraemia without a source was the most common presentation with MRSA.  Infants, children with malnutrition, and residents of long-term care facilities were at highest risk for MRSA bacteraemia. The overall case fatality rate for S. aureus bacteraemia was 8.8% over five years, with MRSA being the only significant risk factor for mortality. CONCLUSION: The incidence of S. aureus bacteraemia and MRSA bacteraemia in children has remained stable over the past five years. MRSA is a predominantly nosocomial pathogen in children with S. aureus bacteraemia in Cape Town, South Africa. DA - 2013 DB - OpenUCT DO - 10.1371/journal.pone.0078396 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africa TI - Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africa UR - http://hdl.handle.net/11427/16270 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16270
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0078396
dc.identifier.vancouvercitationNaidoo R, Nuttall J, Whitelaw A, Eley B. Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africa. PLoS One. 2013; http://hdl.handle.net/11427/16270.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2013 Naidoo et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherMethicillin-resistant Staphylococcus aureusen_ZA
dc.subject.otherChildrenen_ZA
dc.subject.otherNosocomial infectionsen_ZA
dc.subject.otherStaphylococcus aureusen_ZA
dc.subject.otherAntibioticsen_ZA
dc.subject.otherHealthcare-associated infectionsen_ZA
dc.subject.otherVancomycinen_ZA
dc.subject.otherBlooden_ZA
dc.titleEpidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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