Acetaldehyde Adducts in Alcoholic Liver Disease

dc.contributor.authorSetshedi, Mashiko
dc.contributor.authorWands, Jack R
dc.contributor.authorde la Monte, Suzanne M
dc.date.accessioned2021-10-08T07:08:32Z
dc.date.available2021-10-08T07:08:32Z
dc.date.issued2010
dc.description.abstractChronic alcohol abuse causes liver disease that progresses from simple steatosis through stages of steatohepatitis, fibrosis, cirrhosis, and eventually hepatic failure. In addition, chronic alcoholic liver disease (ALD), with or without cirrhosis, increases risk for hepatocellular carcinoma (HCC). Acetaldehyde, a major toxic metabolite, is one of the principal culprits mediating fibrogenic and mutagenic effects of alcohol in the liver. Mechanistically, acetaldehyde promotes adduct formation, leading to functional impairments of key proteins, including enzymes, as well as DNA damage, which promotes mutagenesis. Why certain individuals who heavily abuse alcohol, develop HCC (7.2–15%) versus cirrhosis (15–20%) is not known, but genetics and co-existing viral infection are considered pathogenic factors. Moreover, adverse effects of acetaldehyde on the cardiovascular and hematologic systems leading to ischemia, heart failure, and coagulation disorders, can exacerbate hepatic injury and increase risk for liver failure. Herein, we review the role of acetaldehyde adducts in the pathogenesis of chronic ALD and HCC.
dc.identifier.apacitationSetshedi, M., Wands, J. R., & de la Monte, S. M. (2010). Acetaldehyde Adducts in Alcoholic Liver Disease. <i>Oxidative Medicine and Cellular Longevity</i>, 3(3), 178 - 185. http://hdl.handle.net/11427/34601en_ZA
dc.identifier.chicagocitationSetshedi, Mashiko, Jack R Wands, and Suzanne M de la Monte "Acetaldehyde Adducts in Alcoholic Liver Disease." <i>Oxidative Medicine and Cellular Longevity</i> 3, 3. (2010): 178 - 185. http://hdl.handle.net/11427/34601en_ZA
dc.identifier.citationSetshedi, M., Wands, J.R. & de la Monte, S.M. 2010. Acetaldehyde Adducts in Alcoholic Liver Disease. <i>Oxidative Medicine and Cellular Longevity.</i> 3(3):178 - 185. http://hdl.handle.net/11427/34601en_ZA
dc.identifier.issn1942-0900
dc.identifier.issn1942-0994
dc.identifier.ris TY - Journal Article AU - Setshedi, Mashiko AU - Wands, Jack R AU - de la Monte, Suzanne M AB - Chronic alcohol abuse causes liver disease that progresses from simple steatosis through stages of steatohepatitis, fibrosis, cirrhosis, and eventually hepatic failure. In addition, chronic alcoholic liver disease (ALD), with or without cirrhosis, increases risk for hepatocellular carcinoma (HCC). Acetaldehyde, a major toxic metabolite, is one of the principal culprits mediating fibrogenic and mutagenic effects of alcohol in the liver. Mechanistically, acetaldehyde promotes adduct formation, leading to functional impairments of key proteins, including enzymes, as well as DNA damage, which promotes mutagenesis. Why certain individuals who heavily abuse alcohol, develop HCC (7.2–15%) versus cirrhosis (15–20%) is not known, but genetics and co-existing viral infection are considered pathogenic factors. Moreover, adverse effects of acetaldehyde on the cardiovascular and hematologic systems leading to ischemia, heart failure, and coagulation disorders, can exacerbate hepatic injury and increase risk for liver failure. Herein, we review the role of acetaldehyde adducts in the pathogenesis of chronic ALD and HCC. DA - 2010 DB - OpenUCT DP - University of Cape Town IS - 3 J1 - Oxidative Medicine and Cellular Longevity LK - https://open.uct.ac.za PY - 2010 SM - 1942-0900 SM - 1942-0994 T1 - Acetaldehyde Adducts in Alcoholic Liver Disease TI - Acetaldehyde Adducts in Alcoholic Liver Disease UR - http://hdl.handle.net/11427/34601 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34601
dc.identifier.vancouvercitationSetshedi M, Wands JR, de la Monte SM. Acetaldehyde Adducts in Alcoholic Liver Disease. Oxidative Medicine and Cellular Longevity. 2010;3(3):178 - 185. http://hdl.handle.net/11427/34601.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceOxidative Medicine and Cellular Longevity
dc.source.journalissue3
dc.source.journalvolume3
dc.source.pagination178 - 185
dc.source.urihttps://dx.doi.org/10.4161/oxim.3.3.12288
dc.subject.otheralcohol
dc.subject.othercirrhosis
dc.subject.otherhepatocellular carcinoma
dc.subject.othercancer
dc.subject.otheralcohol metabolism
dc.subject.otheracetaldehyde
dc.subject.otheradducts
dc.subject.otherliver disease
dc.subject.othercardiovascular disease
dc.subject.otheratherosclerosis
dc.titleAcetaldehyde Adducts in Alcoholic Liver Disease
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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