Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity

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dc.contributor.advisorLambert, Estelle Ven_ZA
dc.contributor.advisorMicklesfield, Lisa Ken_ZA
dc.contributor.authorPienaar, Paula Roxanaen_ZA
dc.date.accessioned2015-09-15T10:23:26Z
dc.date.available2015-09-15T10:23:26Z
dc.date.issued2014en_ZA
dc.description.abstractEndothelial dysfunction is associated with cardiovascular disease risk factors and precedes structural changes in the blood vessels that occur prior to clinical manifestations. Measuring ethnic differences in microvascular endothelial function will provide insight into the disparate cardio-metabolic disease profiles that exist within a multi-ethnic South African population. Moreover, it has been shown that insulin resistance is associated with microvascular endothelial dysfunction in obese persons4, but it is unclear whether this relationship is mediated by body fat in apparently healthy individuals with and without insulin resistance. To our knowledge this has not been done in a South African population. Aims: The overall aim of this thesis was to measure microvascular endothelial function using Laser Doppler Imagery (LDI) and iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) in a multi-ethnic, apparently healthy group to determine whether: 1) there are ethnic differences in microvascular endothelial function and 2) whether the association between microvascular endothelial function and insulin resistance (IR) is independent of body fat in women with and without IR.en_ZA
dc.identifier.apacitationPienaar, P. R. (2014). <i>Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/13967en_ZA
dc.identifier.chicagocitationPienaar, Paula Roxana. <i>"Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2014. http://hdl.handle.net/11427/13967en_ZA
dc.identifier.citationPienaar, P. 2014. Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Pienaar, Paula Roxana AB - Endothelial dysfunction is associated with cardiovascular disease risk factors and precedes structural changes in the blood vessels that occur prior to clinical manifestations. Measuring ethnic differences in microvascular endothelial function will provide insight into the disparate cardio-metabolic disease profiles that exist within a multi-ethnic South African population. Moreover, it has been shown that insulin resistance is associated with microvascular endothelial dysfunction in obese persons4, but it is unclear whether this relationship is mediated by body fat in apparently healthy individuals with and without insulin resistance. To our knowledge this has not been done in a South African population. Aims: The overall aim of this thesis was to measure microvascular endothelial function using Laser Doppler Imagery (LDI) and iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) in a multi-ethnic, apparently healthy group to determine whether: 1) there are ethnic differences in microvascular endothelial function and 2) whether the association between microvascular endothelial function and insulin resistance (IR) is independent of body fat in women with and without IR. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity TI - Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity UR - http://hdl.handle.net/11427/13967 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13967
dc.identifier.vancouvercitationPienaar PR. Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/13967en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherExercise Scienceen_ZA
dc.titleMicrovascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivityen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Med)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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