Clinical features and predictors of mortality among hospitalized patients with COVID-19 in Niger

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dc.contributor.authorKatoto, Patrick D M C
dc.contributor.authorAboubacar, Issoufou
dc.contributor.authorOumarou, Batouré
dc.contributor.authorAdehossi, Eric
dc.contributor.authorAnya, Blanche-Philomene M
dc.contributor.authorMounkaila, Aida
dc.contributor.authorMoustapha, Adamou
dc.contributor.authorIshagh, El k
dc.contributor.authorDiawara, Gbaguidi A
dc.contributor.authorNsiari-Muzeyi, Biey J
dc.contributor.authorDidier, Tambwe
dc.contributor.authorWiysonge, Charles S
dc.date.accessioned2022-04-01T13:34:13Z
dc.date.available2022-04-01T13:34:13Z
dc.date.issued2021-12-14
dc.date.updated2021-12-19T04:10:08Z
dc.description.abstractIntroduction COVID-19 has spread across the African continent, including Niger. Yet very little is known about the phenotype of people who tested positive for COVID-19. In this humanitarian crises region, we aimed at characterizing variation in clinical features among hospitalized patients with COVID-19-like syndrome and to determine predictors associated with COVID-19 mortality among those with confirmed COVID-19. Methods The study was a retrospective nationwide cohort of hospitalized patients isolated for COVID-19 infection, using the health data of the National Health Information System from 19 March 2020 (onset of the pandemic) to 17 November 2020. All hospitalized patients with COVID-19-like syndrome at admission were included. A Cox-proportional regression model was built to identify predictors of in-hospital death among patients with confirmed COVID-19. Results Sixty-five percent (472/729) of patients hospitalized with COVID-19 like syndrome tested positive for SARS-CoV-2 among which, 70 (15%) died. Among the patients with confirmed COVID-19 infection, age was significantly associated with increased odds of reporting cough (adjusted odds ratio [aOR] 1.02; 95% confidence interval [CI] 1.01–1.03) and fever/chills (aOR 1.02; 95% CI 1.02–1.04). Comorbidity was associated with increased odds of presenting with cough (aOR 1.59; 95% CI 1.03–2.45) and shortness of breath (aOR 2.03; 95% CI 1.27–3.26) at admission. In addition, comorbidity (adjusted hazards ratio [aHR] 2.04; 95% CI 2.38–6.35), shortness of breath at baseline (aHR 2.04; 95% CI 2.38–6.35) and being 60 years or older (aHR 5.34; 95% CI 3.25–8.75) increased the risk of COVID-19 mortality two to five folds. Conclusion Comorbidity, shortness of breath on admission, and being aged 60 years or older are associated with a higher risk of death among patients hospitalized with COVID-19 in a humanitarian crisis setting. While robust prospective data are needed to guide evidence, our data might aid intensive care resource allocation in Niger.en_US
dc.identifier.apacitationKatoto, P. D. M. C., Aboubacar, I., Oumarou, B., Adehossi, E., Anya, B. M., Mounkaila, A., ... Wiysonge, C. S. (2021). Clinical features and predictors of mortality among hospitalized patients with COVID-19 in Niger. <i>Conflict and Health</i>, 15(1), 89. http://hdl.handle.net/11427/36244en_ZA
dc.identifier.chicagocitationKatoto, Patrick D M C, Issoufou Aboubacar, Batouré Oumarou, Eric Adehossi, Blanche-Philomene M Anya, Aida Mounkaila, Adamou Moustapha, et al "Clinical features and predictors of mortality among hospitalized patients with COVID-19 in Niger." <i>Conflict and Health</i> 15, 1. (2021): 89. http://hdl.handle.net/11427/36244en_ZA
dc.identifier.citationKatoto, P.D.M.C., Aboubacar, I., Oumarou, B., Adehossi, E., Anya, B.M., Mounkaila, A., Moustapha, A. & Ishagh, E.k. et al. 2021. Clinical features and predictors of mortality among hospitalized patients with COVID-19 in Niger. <i>Conflict and Health.</i> 15(1):89. http://hdl.handle.net/11427/36244en_ZA
dc.identifier.ris TY - Journal Article AU - Katoto, Patrick D M C AU - Aboubacar, Issoufou AU - Oumarou, Batouré AU - Adehossi, Eric AU - Anya, Blanche-Philomene M AU - Mounkaila, Aida AU - Moustapha, Adamou AU - Ishagh, El k AU - Diawara, Gbaguidi A AU - Nsiari-Muzeyi, Biey J AU - Didier, Tambwe AU - Wiysonge, Charles S AB - Introduction COVID-19 has spread across the African continent, including Niger. Yet very little is known about the phenotype of people who tested positive for COVID-19. In this humanitarian crises region, we aimed at characterizing variation in clinical features among hospitalized patients with COVID-19-like syndrome and to determine predictors associated with COVID-19 mortality among those with confirmed COVID-19. Methods The study was a retrospective nationwide cohort of hospitalized patients isolated for COVID-19 infection, using the health data of the National Health Information System from 19 March 2020 (onset of the pandemic) to 17 November 2020. All hospitalized patients with COVID-19-like syndrome at admission were included. A Cox-proportional regression model was built to identify predictors of in-hospital death among patients with confirmed COVID-19. Results Sixty-five percent (472/729) of patients hospitalized with COVID-19 like syndrome tested positive for SARS-CoV-2 among which, 70 (15%) died. Among the patients with confirmed COVID-19 infection, age was significantly associated with increased odds of reporting cough (adjusted odds ratio [aOR] 1.02; 95% confidence interval [CI] 1.01–1.03) and fever/chills (aOR 1.02; 95% CI 1.02–1.04). Comorbidity was associated with increased odds of presenting with cough (aOR 1.59; 95% CI 1.03–2.45) and shortness of breath (aOR 2.03; 95% CI 1.27–3.26) at admission. In addition, comorbidity (adjusted hazards ratio [aHR] 2.04; 95% CI 2.38–6.35), shortness of breath at baseline (aHR 2.04; 95% CI 2.38–6.35) and being 60 years or older (aHR 5.34; 95% CI 3.25–8.75) increased the risk of COVID-19 mortality two to five folds. Conclusion Comorbidity, shortness of breath on admission, and being aged 60 years or older are associated with a higher risk of death among patients hospitalized with COVID-19 in a humanitarian crisis setting. While robust prospective data are needed to guide evidence, our data might aid intensive care resource allocation in Niger. DA - 2021-12-14 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Conflict and Health KW - Humanitarian crisis KW - SARS-CoV-2 KW - Baseline characteristics KW - Mortality KW - Africa LK - https://open.uct.ac.za PY - 2021 T1 - Clinical features and predictors of mortality among hospitalized patients with COVID-19 in Niger TI - Clinical features and predictors of mortality among hospitalized patients with COVID-19 in Niger UR - http://hdl.handle.net/11427/36244 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s13031-021-00426-w
dc.identifier.urihttp://hdl.handle.net/11427/36244
dc.identifier.vancouvercitationKatoto PDMC, Aboubacar I, Oumarou B, Adehossi E, Anya BM, Mounkaila A, et al. Clinical features and predictors of mortality among hospitalized patients with COVID-19 in Niger. Conflict and Health. 2021;15(1):89. http://hdl.handle.net/11427/36244.en_ZA
dc.language.isoenen_US
dc.language.rfc3066en
dc.publisher.departmentDepartment of Public Health and Family Medicineen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceConflict and Healthen_US
dc.source.journalissue1en_US
dc.source.journalvolume15en_US
dc.source.pagination89en_US
dc.source.urihttps://conflictandhealth.biomedcentral.com/
dc.subjectHumanitarian crisisen_US
dc.subjectSARS-CoV-2en_US
dc.subjectBaseline characteristicsen_US
dc.subjectMortalityen_US
dc.subjectAfricaen_US
dc.titleClinical features and predictors of mortality among hospitalized patients with COVID-19 in Nigeren_US
dc.typeJournal Articleen_US
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