A prospective randomised trial comparing plastic and uncovered self-expanding metal stents for palliation of symptomatic jaundice in patients with malignant distal biliary obstruction

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dc.contributor.advisorKrige, Jacobus E Jen_ZA
dc.contributor.advisorJonas, Een_ZA
dc.contributor.authorBernon, Marc Michaelen_ZA
dc.date.accessioned2017-09-20T13:51:50Z
dc.date.available2017-09-20T13:51:50Z
dc.date.issued2017en_ZA
dc.description.abstractThe aim of this study was to determine the safety and clinical effectiveness of 10Fr plastic biliary stents compared to uncovered self-expanding metal stents (SEMS) for palliative treatment of patients with inoperable malignant distal biliary obstruction in a public hospital in South Africa. Methods: From January 2009 to December 2013, 40 patients who were admitted to a tertiary academic centre because of distal malignant biliary obstruction were enrolled in a prospective randomised study. Patients were randomly assigned to receive either an uncovered SEMS or a plastic stent deployed through the biliary stricture during endoscopic retrograde cholangiopancreatography. Results: Patient survival time in the two groups did not differ significantly (median: SEMS - 114 days; plastic - 107 days) (p=0.181). Stent failure was more common in the plastic stent group (7/19 vs. 1/20) (p=0.043). The results became significant after 6 months of follow up. There was no significant difference between the two groups in the incidence of serious adverse events. Conclusions: SEMS had a longer duration of patency than plastic stents, which favours their use in the palliative treatment of patients with biliary obstruction due to distal malignant biliary obstruction.en_ZA
dc.identifier.apacitationBernon, M. M. (2017). <i>A prospective randomised trial comparing plastic and uncovered self-expanding metal stents for palliation of symptomatic jaundice in patients with malignant distal biliary obstruction</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Surgical Gastroenterology. Retrieved from http://hdl.handle.net/11427/25252en_ZA
dc.identifier.chicagocitationBernon, Marc Michael. <i>"A prospective randomised trial comparing plastic and uncovered self-expanding metal stents for palliation of symptomatic jaundice in patients with malignant distal biliary obstruction."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Surgical Gastroenterology, 2017. http://hdl.handle.net/11427/25252en_ZA
dc.identifier.citationBernon, M. 2017. A prospective randomised trial comparing plastic and uncovered self-expanding metal stents for palliation of symptomatic jaundice in patients with malignant distal biliary obstruction. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Bernon, Marc Michael AB - The aim of this study was to determine the safety and clinical effectiveness of 10Fr plastic biliary stents compared to uncovered self-expanding metal stents (SEMS) for palliative treatment of patients with inoperable malignant distal biliary obstruction in a public hospital in South Africa. Methods: From January 2009 to December 2013, 40 patients who were admitted to a tertiary academic centre because of distal malignant biliary obstruction were enrolled in a prospective randomised study. Patients were randomly assigned to receive either an uncovered SEMS or a plastic stent deployed through the biliary stricture during endoscopic retrograde cholangiopancreatography. Results: Patient survival time in the two groups did not differ significantly (median: SEMS - 114 days; plastic - 107 days) (p=0.181). Stent failure was more common in the plastic stent group (7/19 vs. 1/20) (p=0.043). The results became significant after 6 months of follow up. There was no significant difference between the two groups in the incidence of serious adverse events. Conclusions: SEMS had a longer duration of patency than plastic stents, which favours their use in the palliative treatment of patients with biliary obstruction due to distal malignant biliary obstruction. DA - 2017 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2017 T1 - A prospective randomised trial comparing plastic and uncovered self-expanding metal stents for palliation of symptomatic jaundice in patients with malignant distal biliary obstruction TI - A prospective randomised trial comparing plastic and uncovered self-expanding metal stents for palliation of symptomatic jaundice in patients with malignant distal biliary obstruction UR - http://hdl.handle.net/11427/25252 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/25252
dc.identifier.vancouvercitationBernon MM. A prospective randomised trial comparing plastic and uncovered self-expanding metal stents for palliation of symptomatic jaundice in patients with malignant distal biliary obstruction. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Surgical Gastroenterology, 2017 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/25252en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Surgical Gastroenterologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherSurgical Gastroenterologyen_ZA
dc.titleA prospective randomised trial comparing plastic and uncovered self-expanding metal stents for palliation of symptomatic jaundice in patients with malignant distal biliary obstructionen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMPhilen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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