High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors
| dc.contributor.author | Omar, Fierdoz | |
| dc.contributor.author | Dave, Joel A | |
| dc.contributor.author | King, Judy A | |
| dc.contributor.author | Levitt, Naomi S | |
| dc.contributor.author | Pillay, Tahir S | |
| dc.date.accessioned | 2015-07-30T04:02:20Z | |
| dc.date.available | 2015-07-30T04:02:20Z | |
| dc.date.issued | 2014-12-16 | |
| dc.date.updated | 2015-01-15T17:52:45Z | |
| dc.description.abstract | Abstract Background At the time of the study, the HIV-treatment policy in South Africa included highly active antiretroviral therapy (HAART) regimens 1 (nucleotide reverse transcriptase inhibitors (NRTIs) only), and 2 (protease inhibitors (PI) and NRTIs). HAART is associated with the lipodystrophy syndrome, insulin resistance and reduced total adiponectin (TA) levels. The high molecular weight (HMW):TA ratio is a superior marker of insulin resistance. The aim of this study was to establish whether HMW:TA ratios are low in patients on PIs and whether they correlate with insulin resistance. Methods This was a cross-sectional study undertaken in an antiretroviral clinic at a tertiary hospital. The participants were 66 HIV-infected females: 22 were on regimen 2 (PI group), 22 on regimen 1 (non-PI) and 22 treatment naïve (TN), matched for BMI and age. Patients with a history of diabetes or impaired glucose tolerance were excluded. Serum adiponectin multimers were analysed using the AlpcoTM Adiponectin (Multimeric) enzyme immunoassay. Waist hip ratios (WHR), glucose and insulin levels were assessed, and HOMA-IR and QUICKI calculated. Data were analysed non-parametrically and multivariate analysis was performed. Results TA and HMW levels were lower in the treatment groups than in the TN group. HMW:TA was lower in the PI than in the non-PI and TN groups, and in the non-PI than in the TN groups. HMW:TA correlated negatively with waist, insulin and HOMA-IR, independently of BMI and duration of therapy. HOMA-IR and QUICKI did not differ among the groups. Conclusion HMW:TA is significantly decreased with HAART (particularly with PIs, but also with non-PIs) and may be a more sensitive marker of insulin resistance in these patients than conventional markers or HMW and total adiponectin individually. | |
| dc.identifier.apacitation | Omar, F., Dave, J. A., King, J. A., Levitt, N. S., & Pillay, T. S. (2014). High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors. <i>BMC Clinical Pathology</i>, http://hdl.handle.net/11427/13618 | en_ZA |
| dc.identifier.chicagocitation | Omar, Fierdoz, Joel A Dave, Judy A King, Naomi S Levitt, and Tahir S Pillay "High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors." <i>BMC Clinical Pathology</i> (2014) http://hdl.handle.net/11427/13618 | en_ZA |
| dc.identifier.citation | Omar, F., Dave, J. A., King, J. A., Levitt, N. S., & Pillay, T. S. (2014). High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors. BMC clinical pathology, 14(1), 46. | |
| dc.identifier.ris | TY - Journal Article AU - Omar, Fierdoz AU - Dave, Joel A AU - King, Judy A AU - Levitt, Naomi S AU - Pillay, Tahir S AB - Abstract Background At the time of the study, the HIV-treatment policy in South Africa included highly active antiretroviral therapy (HAART) regimens 1 (nucleotide reverse transcriptase inhibitors (NRTIs) only), and 2 (protease inhibitors (PI) and NRTIs). HAART is associated with the lipodystrophy syndrome, insulin resistance and reduced total adiponectin (TA) levels. The high molecular weight (HMW):TA ratio is a superior marker of insulin resistance. The aim of this study was to establish whether HMW:TA ratios are low in patients on PIs and whether they correlate with insulin resistance. Methods This was a cross-sectional study undertaken in an antiretroviral clinic at a tertiary hospital. The participants were 66 HIV-infected females: 22 were on regimen 2 (PI group), 22 on regimen 1 (non-PI) and 22 treatment naïve (TN), matched for BMI and age. Patients with a history of diabetes or impaired glucose tolerance were excluded. Serum adiponectin multimers were analysed using the AlpcoTM Adiponectin (Multimeric) enzyme immunoassay. Waist hip ratios (WHR), glucose and insulin levels were assessed, and HOMA-IR and QUICKI calculated. Data were analysed non-parametrically and multivariate analysis was performed. Results TA and HMW levels were lower in the treatment groups than in the TN group. HMW:TA was lower in the PI than in the non-PI and TN groups, and in the non-PI than in the TN groups. HMW:TA correlated negatively with waist, insulin and HOMA-IR, independently of BMI and duration of therapy. HOMA-IR and QUICKI did not differ among the groups. Conclusion HMW:TA is significantly decreased with HAART (particularly with PIs, but also with non-PIs) and may be a more sensitive marker of insulin resistance in these patients than conventional markers or HMW and total adiponectin individually. DA - 2014-12-16 DB - OpenUCT DO - 10.1186/1472-6890-14-46 DP - University of Cape Town J1 - BMC Clinical Pathology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors TI - High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors UR - http://hdl.handle.net/11427/13618 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/13618 | |
| dc.identifier.uri | http://dx.doi.org/10.1186/1472-6890-14-46 | |
| dc.identifier.vancouvercitation | Omar F, Dave JA, King JA, Levitt NS, Pillay TS. High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors. BMC Clinical Pathology. 2014; http://hdl.handle.net/11427/13618. | en_ZA |
| dc.language.rfc3066 | en | |
| dc.publisher.department | Division of Chemical Pathology | en_ZA |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License | * |
| dc.rights.holder | Omar et al.; licensee BioMed Central. | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | * |
| dc.source | BMC Clinical Pathology | en_ZA |
| dc.source.uri | http://www.biomedcentral.com/bmcclinpathol/ | |
| dc.subject.other | HMW adiponectin | en_ZA |
| dc.subject.other | Lipodystrophy syndrome | en_ZA |
| dc.subject.other | HMW: adiponectin ratio | en_ZA |
| dc.subject.other | Protease inhibitors | en_ZA |
| dc.subject.other | Insulin resistance | en_ZA |
| dc.title | High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors | |
| dc.type | Journal Article | en_ZA |
| uct.type.filetype | ||
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |