Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa

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dc.contributor.advisorArgent, Andrew Cen_ZA
dc.contributor.authorSalie, Mogamat Shamielen_ZA
dc.date.accessioned2016-06-02T08:48:01Z
dc.date.available2016-06-02T08:48:01Z
dc.date.issued2015en_ZA
dc.description.abstractDuring the mid to late 1990's, nearly all HIV infected children admitted to South African paediatric intensive care units died. This was in the context of an increasing HIV epidemic in Sub-Saharan Africa, a limited number of intensive care beds in public hospitals and the South African government refusing to supply antiretroviral medication to public sector patients. HIV infected children all die without ARV medication, and it resulted in an increase in the South African under-5 mortality rate. In this context critically ill HIV infected children were often denied PICU admission. Developed countries introduced ARV medication in the early 1990's and the South African government only started supplying ARV medication in late 2003. When ARV medication became available in South Africa, it was started on the basis of the individual child's clinical and immunological status and there was not much published data on initiation of ARV therapy in critical ill children in intensive care units. Many HIV infected children had recurrent hospital admissions and many children died before initiating ARV medication. HIV infected children are not only susceptible to the normal bacteria and viruses, but at increased risk of opportunistic and mycobacterial infections. CMV has increasingly been recognized as a common co-infection with PCP, but has been difficult to diagnose and treat effectively. We retrospectively reviewed all HIV exposed and infected children admitted to our PICU in 2009. In addition to our standard treatment, we initiated ARV medication as soon as logistically possible and children with suspected CMV infections were empirically treated with gancyclovir.en_ZA
dc.identifier.apacitationSalie, M. S. (2015). <i>Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. Retrieved from http://hdl.handle.net/11427/19900en_ZA
dc.identifier.chicagocitationSalie, Mogamat Shamiel. <i>"Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2015. http://hdl.handle.net/11427/19900en_ZA
dc.identifier.citationSalie, M. 2015. Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Salie, Mogamat Shamiel AB - During the mid to late 1990's, nearly all HIV infected children admitted to South African paediatric intensive care units died. This was in the context of an increasing HIV epidemic in Sub-Saharan Africa, a limited number of intensive care beds in public hospitals and the South African government refusing to supply antiretroviral medication to public sector patients. HIV infected children all die without ARV medication, and it resulted in an increase in the South African under-5 mortality rate. In this context critically ill HIV infected children were often denied PICU admission. Developed countries introduced ARV medication in the early 1990's and the South African government only started supplying ARV medication in late 2003. When ARV medication became available in South Africa, it was started on the basis of the individual child's clinical and immunological status and there was not much published data on initiation of ARV therapy in critical ill children in intensive care units. Many HIV infected children had recurrent hospital admissions and many children died before initiating ARV medication. HIV infected children are not only susceptible to the normal bacteria and viruses, but at increased risk of opportunistic and mycobacterial infections. CMV has increasingly been recognized as a common co-infection with PCP, but has been difficult to diagnose and treat effectively. We retrospectively reviewed all HIV exposed and infected children admitted to our PICU in 2009. In addition to our standard treatment, we initiated ARV medication as soon as logistically possible and children with suspected CMV infections were empirically treated with gancyclovir. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa TI - Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa UR - http://hdl.handle.net/11427/19900 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/19900
dc.identifier.vancouvercitationSalie MS. Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/19900en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Paediatrics and Child Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherClinical Researchen_ZA
dc.titleOutcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africaen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMPHen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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