Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps

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dc.contributor.authorBateman, Ericen_ZA
dc.contributor.authorHarrison, Timen_ZA
dc.contributor.authorQuirce, Santiagoen_ZA
dc.contributor.authorReddel, Helenen_ZA
dc.contributor.authorBuhl, Rolanden_ZA
dc.contributor.authorHumbert, Marcen_ZA
dc.contributor.authorJenkins, Christineen_ZA
dc.contributor.authorPeterson, Stefanen_ZA
dc.contributor.authorOstlund, Ollieen_ZA
dc.contributor.authorO'Byrne, Paulen_ZA
dc.contributor.authorSears, Malcolmen_ZA
dc.contributor.authorEriksson, Goranen_ZA
dc.date.accessioned2015-11-11T11:53:42Z
dc.date.available2015-11-11T11:53:42Z
dc.date.issued2011en_ZA
dc.description.abstractBACKGROUND: Adjusting medication for uncontrolled asthma involves selecting one of several options from the same or a higher treatment step outlined in asthma guidelines. We examined the relative benefit of introducing budesonide/formoterol (BUD/FORM) maintenance and reliever therapy (Symbicort SMART(R) Turbuhaler(R)) in patients previously prescribed treatments from Global Initiative for Asthma (GINA) Steps 2, 3 or 4. METHODS: This is a post hoc analysis of the results of five large clinical trials (>12000 patients) comparing BUD/FORM maintenance and reliever therapy with other treatments categorised by treatment step at study entry. Both current clinical asthma control during the last week of treatment and exacerbations during the study were examined. RESULTS: At each GINA treatment step, the proportion of patients achieving target levels of current clinical control were similar or higher with BUD/FORM maintenance and reliever therapy compared with the same or a higher fixed maintenance dose of inhaled corticosteroid/long-acting beta2-agonist (ICS/LABA) (plus short-acting beta2-agonist [SABA] as reliever), and rates of exacerbations were lower at all treatment steps in BUD/FORM maintenance and reliever therapy versus same maintenance dose ICS/LABA (P < 0.01) and at treatment Step 4 versus higher maintenance dose ICS/LABA (P < 0.001). BUD/FORM maintenance and reliever therapy also achieved significantly higher rates of current clinical control and significantly lower exacerbation rates at most treatment steps compared with a higher maintenance dose ICS + SABA (Steps 2-4 for control and Steps 3 and 4 for exacerbations). With all treatments, the proportion of patients achieving current clinical control was lower with increasing treatment steps. CONCLUSIONS: BUD/FORM maintenance and reliever therapy may be a preferable option for patients on Steps 2 to 4 of asthma guidelines requiring a more effective treatment and, compared with other fixed dose alternatives, is most effective in the higher treatment steps.en_ZA
dc.identifier.apacitationBateman, E., Harrison, T., Quirce, S., Reddel, H., Buhl, R., Humbert, M., ... Eriksson, G. (2011). Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps. <i>Respiratory Research</i>, http://hdl.handle.net/11427/14860en_ZA
dc.identifier.chicagocitationBateman, Eric, Tim Harrison, Santiago Quirce, Helen Reddel, Roland Buhl, Marc Humbert, Christine Jenkins, et al "Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps." <i>Respiratory Research</i> (2011) http://hdl.handle.net/11427/14860en_ZA
dc.identifier.citationBateman, E. D., Harrison, T. W., Quirce, S., Reddel, H. K., Buhl, R., Humbert, M., ... & Eriksson, G. S. (2011). Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps. Respir Res, 12(1), 38.en_ZA
dc.identifier.ris TY - Journal Article AU - Bateman, Eric AU - Harrison, Tim AU - Quirce, Santiago AU - Reddel, Helen AU - Buhl, Roland AU - Humbert, Marc AU - Jenkins, Christine AU - Peterson, Stefan AU - Ostlund, Ollie AU - O'Byrne, Paul AU - Sears, Malcolm AU - Eriksson, Goran AB - BACKGROUND: Adjusting medication for uncontrolled asthma involves selecting one of several options from the same or a higher treatment step outlined in asthma guidelines. We examined the relative benefit of introducing budesonide/formoterol (BUD/FORM) maintenance and reliever therapy (Symbicort SMART(R) Turbuhaler(R)) in patients previously prescribed treatments from Global Initiative for Asthma (GINA) Steps 2, 3 or 4. METHODS: This is a post hoc analysis of the results of five large clinical trials (>12000 patients) comparing BUD/FORM maintenance and reliever therapy with other treatments categorised by treatment step at study entry. Both current clinical asthma control during the last week of treatment and exacerbations during the study were examined. RESULTS: At each GINA treatment step, the proportion of patients achieving target levels of current clinical control were similar or higher with BUD/FORM maintenance and reliever therapy compared with the same or a higher fixed maintenance dose of inhaled corticosteroid/long-acting beta2-agonist (ICS/LABA) (plus short-acting beta2-agonist [SABA] as reliever), and rates of exacerbations were lower at all treatment steps in BUD/FORM maintenance and reliever therapy versus same maintenance dose ICS/LABA (P < 0.01) and at treatment Step 4 versus higher maintenance dose ICS/LABA (P < 0.001). BUD/FORM maintenance and reliever therapy also achieved significantly higher rates of current clinical control and significantly lower exacerbation rates at most treatment steps compared with a higher maintenance dose ICS + SABA (Steps 2-4 for control and Steps 3 and 4 for exacerbations). With all treatments, the proportion of patients achieving current clinical control was lower with increasing treatment steps. CONCLUSIONS: BUD/FORM maintenance and reliever therapy may be a preferable option for patients on Steps 2 to 4 of asthma guidelines requiring a more effective treatment and, compared with other fixed dose alternatives, is most effective in the higher treatment steps. DA - 2011 DB - OpenUCT DO - 10.1186/1465-9921-12-38 DP - University of Cape Town J1 - Respiratory Research LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps TI - Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps UR - http://hdl.handle.net/11427/14860 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14860
dc.identifier.urihttp://dx.doi.org/10.1186/1465-9921-12-38
dc.identifier.vancouvercitationBateman E, Harrison T, Quirce S, Reddel H, Buhl R, Humbert M, et al. Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps. Respiratory Research. 2011; http://hdl.handle.net/11427/14860.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Pulmonologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2011 Bateman et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceRespiratory Researchen_ZA
dc.source.urihttp://www.respiratory-research.com/en_ZA
dc.subject.otherCurrent Asthma Controlen_ZA
dc.subject.otherGINA Stepen_ZA
dc.subject.otherComparator Treatment Groupen_ZA
dc.subject.otherClinical Asthma Controlen_ZA
dc.subject.otherICS Doseen_ZA
dc.titleOverall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment stepsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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