Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass

dc.contributor.authorHarper, Andrew Ren_ZA
dc.contributor.authorMayosi, Bongani Men_ZA
dc.contributor.authorRodriguez, Antonyen_ZA
dc.contributor.authorRahman, Thahiraen_ZA
dc.contributor.authorHall, Darrochen_ZA
dc.contributor.authorMamasoula, Chrysovalantoen_ZA
dc.contributor.authorAvery, Peter Jen_ZA
dc.contributor.authorKeavney, Bernard Den_ZA
dc.date.accessioned2015-11-23T12:36:57Z
dc.date.available2015-11-23T12:36:57Z
dc.date.issued2013en_ZA
dc.description.abstractAIMS: Previous genome-wide linkage analysis has suggested that chromosomal region 17p13.3 may harbour genes influencing left ventricular mass (LVM) in man. To date, the genetic factors accounting for LVM variability remain largely unknown but a non-coding RNA gene within this region, micro-RNA 22 (miR-22) , has been implicated in cardiac hypertrophy and heart failure in animal models. We thus investigated the relationship between common genetic polymorphisms surrounding miR-22 and left ventricular mass in a family-based association study. Methods and RESULTS: We studied a cohort of 255 families comprising 1,425 individuals ascertained via a hypertensive proband. Ten single nucleotide polymorphisms which together tagged common genetic variation surrounding the miR-22 gene were genotyped. There was evidence of association between the rs7223247 polymorphism, which lies within the 3′UTR of a gene of unknown function, TLCD2, immediately downstream from miR-22, and left ventricular mass determined by Sokolow-Lyon voltage (Bonferroni corrected p- value = 0.038). The T allele at rs7223247 was associated with an 0.272 standard deviation higher Sokolow-Lyon voltage. Genotype was responsible for ∼1% of the population variability in LVM. CONCLUSIONS: Genotype at the rs7223247 polymorphism affects left ventricular mass determined by Sokolow-Lyon voltage. The neighbouring genes miR-22 and TLCD2 are strong candidates to account for this observation.en_ZA
dc.identifier.apacitationHarper, A. R., Mayosi, B. M., Rodriguez, A., Rahman, T., Hall, D., Mamasoula, C., ... Keavney, B. D. (2013). Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass. <i>PLoS One</i>, http://hdl.handle.net/11427/15347en_ZA
dc.identifier.chicagocitationHarper, Andrew R, Bongani M Mayosi, Antony Rodriguez, Thahira Rahman, Darroch Hall, Chrysovalanto Mamasoula, Peter J Avery, and Bernard D Keavney "Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass." <i>PLoS One</i> (2013) http://hdl.handle.net/11427/15347en_ZA
dc.identifier.citationHarper, A. R., Mayosi, B. M., Rodriguez, A., Rahman, T., Hall, D., Mamasoula, C., ... & Keavney, B. D. (2013). Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass. PloS one, 8(1), e55061. doi:10.1371/journal.pone.0055061en_ZA
dc.identifier.ris TY - Journal Article AU - Harper, Andrew R AU - Mayosi, Bongani M AU - Rodriguez, Antony AU - Rahman, Thahira AU - Hall, Darroch AU - Mamasoula, Chrysovalanto AU - Avery, Peter J AU - Keavney, Bernard D AB - AIMS: Previous genome-wide linkage analysis has suggested that chromosomal region 17p13.3 may harbour genes influencing left ventricular mass (LVM) in man. To date, the genetic factors accounting for LVM variability remain largely unknown but a non-coding RNA gene within this region, micro-RNA 22 (miR-22) , has been implicated in cardiac hypertrophy and heart failure in animal models. We thus investigated the relationship between common genetic polymorphisms surrounding miR-22 and left ventricular mass in a family-based association study. Methods and RESULTS: We studied a cohort of 255 families comprising 1,425 individuals ascertained via a hypertensive proband. Ten single nucleotide polymorphisms which together tagged common genetic variation surrounding the miR-22 gene were genotyped. There was evidence of association between the rs7223247 polymorphism, which lies within the 3′UTR of a gene of unknown function, TLCD2, immediately downstream from miR-22, and left ventricular mass determined by Sokolow-Lyon voltage (Bonferroni corrected p- value = 0.038). The T allele at rs7223247 was associated with an 0.272 standard deviation higher Sokolow-Lyon voltage. Genotype was responsible for ∼1% of the population variability in LVM. CONCLUSIONS: Genotype at the rs7223247 polymorphism affects left ventricular mass determined by Sokolow-Lyon voltage. The neighbouring genes miR-22 and TLCD2 are strong candidates to account for this observation. DA - 2013 DB - OpenUCT DO - 10.1371/journal.pone.0055061 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass TI - Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass UR - http://hdl.handle.net/11427/15347 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15347
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0055061
dc.identifier.vancouvercitationHarper AR, Mayosi BM, Rodriguez A, Rahman T, Hall D, Mamasoula C, et al. Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass. PLoS One. 2013; http://hdl.handle.net/11427/15347.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2013 Harper et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherElectrocardiographyen_ZA
dc.subject.otherCardiac hypertrophyen_ZA
dc.subject.otherHypertensionen_ZA
dc.subject.otherGenome-wide association studiesen_ZA
dc.subject.otherVariant genotypesen_ZA
dc.subject.otherBlood pressureen_ZA
dc.subject.otherGenotypingen_ZA
dc.subject.otherMicroRNAsen_ZA
dc.titleCommon variation neighbouring micro-RNA 22 is associated with increased left ventricular massen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Harper_Common_variation_2013.pdf
Size:
391.58 KB
Format:
Adobe Portable Document Format
Description:
Collections