Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa

dc.contributor.authorNglazi, Mweete D
dc.contributor.authorWest, Sacha J
dc.contributor.authorDave, Joel A
dc.contributor.authorLevitt, Naomi S
dc.contributor.authorLambert, Estelle V
dc.date.accessioned2015-01-21T12:25:47Z
dc.date.available2015-01-21T12:25:47Z
dc.date.issued2014-07-03
dc.date.updated2015-01-15T17:59:00Z
dc.description.abstractBackground: Health related quality of life (HRQoL) is an important outcome helping to understand the impact of antiretroviral therapy (ART). We examined and compared the HRQoL in relation to ART status among HIV-infected patients in a public sector service in Cape Town, South Africa. In addition, we aimed to examine the relationship between ART status and HRQoL according to CD4 count strata. Methods: A cross sectional study sample of 903 HIV-infected patients who were categorized as not receiving ART (ART-naïve) or receiving first-line ART for > 6 months (ART). HRQoL outcomes were compared in the two groups. HRQoL was assessed using the EQ-5D (five domains) and Visual Analogue Scale (EQ-5D VAS). Results: Of the total sample, 435 were categorised as ART naïve (76% women) and 468 were on ART (78% women). There were no significant associations between groups for most of the EQ-5D domains, however ART-naïve experienced a significantly greater problem with mobility than the ART group. Being ART-naïve (adjusted odds ratio (aOR) 3.08 95% confidence interval (CI) 1.63- 7.89) and obese 2.78 (95% CI 1.24- 6.22) were identified as predictors for increased mobility problems in multivariate analysis. In addition, receiving ART (5.61 difference; 95% CI 2.50 - 8.72) and having some source of income (4.76; 95% CI 1.63 -7.89) were identified as predictors for a higher EQ-5D VAS score. When grouped according to CD4 count strata, there were no significant difference between groups for most of the EQ-5D domains, however the ART-naïve group indicated having significantly greater problems under the CD4 count of >500 cells/μL in the anxiety/depression domain (22.4% vs 8.8%, p = 0.018) and significantly lower EQ-5D VAS scores under the CD4 counts of ≤200 cells/μL (median 80 (IQR 60–90) vs 90 (IQR 80–100), p = 0.0003) and 201–350 cells/μL (median 80 (IQR 70–90) vs 90 (80–100), p = 0.0004) compared to ART group. Conclusions: HRQoL (self-rated health state) was improved with ART use, including those with immunocompromised status, which may be relevant to the public sector ART program in South Africa.en_ZA
dc.identifier.apacitationNglazi, M. D., West, S. J., Dave, J. A., Levitt, N. S., & Lambert, E. V. (2014). Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa. <i>BMC Public Health</i>, http://hdl.handle.net/11427/12286en_ZA
dc.identifier.chicagocitationNglazi, Mweete D, Sacha J West, Joel A Dave, Naomi S Levitt, and Estelle V Lambert "Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa." <i>BMC Public Health</i> (2014) http://hdl.handle.net/11427/12286en_ZA
dc.identifier.citationNglazi et al.: Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa. BMC Public Health. 2014 Jul 03;14(1):676en_ZA
dc.identifier.issn1471-2458en_ZA
dc.identifier.ris TY - Journal Article AU - Nglazi, Mweete D AU - West, Sacha J AU - Dave, Joel A AU - Levitt, Naomi S AU - Lambert, Estelle V AB - Background: Health related quality of life (HRQoL) is an important outcome helping to understand the impact of antiretroviral therapy (ART). We examined and compared the HRQoL in relation to ART status among HIV-infected patients in a public sector service in Cape Town, South Africa. In addition, we aimed to examine the relationship between ART status and HRQoL according to CD4 count strata. Methods: A cross sectional study sample of 903 HIV-infected patients who were categorized as not receiving ART (ART-naïve) or receiving first-line ART for > 6 months (ART). HRQoL outcomes were compared in the two groups. HRQoL was assessed using the EQ-5D (five domains) and Visual Analogue Scale (EQ-5D VAS). Results: Of the total sample, 435 were categorised as ART naïve (76% women) and 468 were on ART (78% women). There were no significant associations between groups for most of the EQ-5D domains, however ART-naïve experienced a significantly greater problem with mobility than the ART group. Being ART-naïve (adjusted odds ratio (aOR) 3.08 95% confidence interval (CI) 1.63- 7.89) and obese 2.78 (95% CI 1.24- 6.22) were identified as predictors for increased mobility problems in multivariate analysis. In addition, receiving ART (5.61 difference; 95% CI 2.50 - 8.72) and having some source of income (4.76; 95% CI 1.63 -7.89) were identified as predictors for a higher EQ-5D VAS score. When grouped according to CD4 count strata, there were no significant difference between groups for most of the EQ-5D domains, however the ART-naïve group indicated having significantly greater problems under the CD4 count of >500 cells/μL in the anxiety/depression domain (22.4% vs 8.8%, p = 0.018) and significantly lower EQ-5D VAS scores under the CD4 counts of ≤200 cells/μL (median 80 (IQR 60–90) vs 90 (IQR 80–100), p = 0.0003) and 201–350 cells/μL (median 80 (IQR 70–90) vs 90 (80–100), p = 0.0004) compared to ART group. Conclusions: HRQoL (self-rated health state) was improved with ART use, including those with immunocompromised status, which may be relevant to the public sector ART program in South Africa. DA - 2014-07-03 DB - OpenUCT DO - 10.1186/1471-2458-14-676 DP - University of Cape Town J1 - BMC Public Health LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 SM - 1471-2458 T1 - Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa TI - Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa UR - http://hdl.handle.net/11427/12286 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2458-14-676
dc.identifier.urihttp://hdl.handle.net/11427/12286
dc.identifier.urihttp://hdl.handle.net/11427/12286
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2458-14-676
dc.identifier.vancouvercitationNglazi MD, West SJ, Dave JA, Levitt NS, Lambert EV. Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa. BMC Public Health. 2014; http://hdl.handle.net/11427/12286.en_ZA
dc.languageengen_ZA
dc.language.rfc3066en
dc.publisherBioMed Centralen_ZA
dc.publisher.departmentMRC/UCT RU for Exercise and Sport Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rights.holderNglazi et al.; licensee BioMed Central Ltd.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_ZA
dc.sourceBMC Public Healthen_ZA
dc.source.urihttp://www.biomedcentral.com/1471-2458
dc.subject.otherHealth related quality of lifeen_ZA
dc.subject.otherHIV/AIDSen_ZA
dc.subject.otherHealth outcomesen_ZA
dc.subject.otherEQ-5Den_ZA
dc.titleQuality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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