Distribution of Human Papillomavirus (HPV) Genotypes in HIV-Negative and HIV-Positive Women with Cervical Intraepithelial Lesions in the Eastern Cape Province, South Africa
| dc.contributor.author | Taku, Ongeziwe | |
| dc.contributor.author | Mbulawa, Zizipho Z A | |
| dc.contributor.author | Phohlo, Keletso | |
| dc.contributor.author | Garcia-Jardon, Mirta | |
| dc.contributor.author | Businge, Charles B | |
| dc.contributor.author | Williamson, Anna-Lise | |
| dc.date.accessioned | 2021-10-19T15:16:10Z | |
| dc.date.available | 2021-10-19T15:16:10Z | |
| dc.date.issued | 2021-02-11 | |
| dc.date.updated | 2021-02-26T14:53:40Z | |
| dc.description.abstract | South African women have a high rate of cervical cancer cases, but there are limited data on human papillomavirus (HPV) genotypes in cervical intraepithelial neoplasia (CIN) in the Eastern Cape province, South Africa. A total of 193 cervical specimens with confirmed CIN from women aged 18 years or older, recruited from a referral hospital, were tested for HPV infection. The cervical specimens, smeared onto FTA cards, were screened for 36 HPV types using an HPV direct flow kit. HPV prevalence was 93.5% (43/46) in CIN2 and 96.6% (142/147) in CIN3. HIV-positive women had a significantly higher HPV prevalence than HIV-negative women (98.0% vs. 89.1%, p = 0.012). The prevalence of multiple types was significantly higher in HIV-positive than HIV-negative women (p = 0.034). The frequently detected genotypes were HPV35 (23.9%), HPV58 (23.9%), HPV45 (19.6%), and HPV16 (17.3%) in CIN2 cases, while in CIN3, HPV35 (22.5%), HPV16 (21.8%), HPV33 (15.6%), and HPV58 (14.3%) were the most common identified HPV types, independent of HIV status. The prevalence of HPV types targeted by the nonavalent HPV vaccine was 60.9% and 68.7% among women with CIN2 and CIN3, respectively, indicating that vaccination would have an impact both in HIV-negative and HIV-positive South African women, although it will not provide full protection in preventing HPV infection and cervical cancer lesions. | en_US |
| dc.identifier | doi: 10.3390/v13020280 | |
| dc.identifier.apacitation | Taku, O., Mbulawa, Z. Z. A., Phohlo, K., Garcia-Jardon, M., Businge, C. B., & Williamson, A. (2021). Distribution of Human Papillomavirus (HPV) Genotypes in HIV-Negative and HIV-Positive Women with Cervical Intraepithelial Lesions in the Eastern Cape Province, South Africa. <i>Viruses</i>, 13(2), http://hdl.handle.net/11427/35272 | en_ZA |
| dc.identifier.chicagocitation | Taku, Ongeziwe, Zizipho Z A Mbulawa, Keletso Phohlo, Mirta Garcia-Jardon, Charles B Businge, and Anna-Lise Williamson "Distribution of Human Papillomavirus (HPV) Genotypes in HIV-Negative and HIV-Positive Women with Cervical Intraepithelial Lesions in the Eastern Cape Province, South Africa." <i>Viruses</i> 13, 2. (2021) http://hdl.handle.net/11427/35272 | en_ZA |
| dc.identifier.citation | Taku, O., Mbulawa, Z.Z.A., Phohlo, K., Garcia-Jardon, M., Businge, C.B. & Williamson, A. 2021. Distribution of Human Papillomavirus (HPV) Genotypes in HIV-Negative and HIV-Positive Women with Cervical Intraepithelial Lesions in the Eastern Cape Province, South Africa. <i>Viruses.</i> 13(2) http://hdl.handle.net/11427/35272 | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - Taku, Ongeziwe AU - Mbulawa, Zizipho Z A AU - Phohlo, Keletso AU - Garcia-Jardon, Mirta AU - Businge, Charles B AU - Williamson, Anna-Lise AB - South African women have a high rate of cervical cancer cases, but there are limited data on human papillomavirus (HPV) genotypes in cervical intraepithelial neoplasia (CIN) in the Eastern Cape province, South Africa. A total of 193 cervical specimens with confirmed CIN from women aged 18 years or older, recruited from a referral hospital, were tested for HPV infection. The cervical specimens, smeared onto FTA cards, were screened for 36 HPV types using an HPV direct flow kit. HPV prevalence was 93.5% (43/46) in CIN2 and 96.6% (142/147) in CIN3. HIV-positive women had a significantly higher HPV prevalence than HIV-negative women (98.0% vs. 89.1%, p = 0.012). The prevalence of multiple types was significantly higher in HIV-positive than HIV-negative women (p = 0.034). The frequently detected genotypes were HPV35 (23.9%), HPV58 (23.9%), HPV45 (19.6%), and HPV16 (17.3%) in CIN2 cases, while in CIN3, HPV35 (22.5%), HPV16 (21.8%), HPV33 (15.6%), and HPV58 (14.3%) were the most common identified HPV types, independent of HIV status. The prevalence of HPV types targeted by the nonavalent HPV vaccine was 60.9% and 68.7% among women with CIN2 and CIN3, respectively, indicating that vaccination would have an impact both in HIV-negative and HIV-positive South African women, although it will not provide full protection in preventing HPV infection and cervical cancer lesions. DA - 2021-02-11 DB - OpenUCT DP - University of Cape Town IS - 2 J1 - Viruses KW - human papillomavirus KW - human immunodeficiency virus KW - cervical intraepithelial lesions KW - South Africa LK - https://open.uct.ac.za PY - 2021 T1 - Distribution of Human Papillomavirus (HPV) Genotypes in HIV-Negative and HIV-Positive Women with Cervical Intraepithelial Lesions in the Eastern Cape Province, South Africa TI - Distribution of Human Papillomavirus (HPV) Genotypes in HIV-Negative and HIV-Positive Women with Cervical Intraepithelial Lesions in the Eastern Cape Province, South Africa UR - http://hdl.handle.net/11427/35272 ER - | en_ZA |
| dc.identifier.uri | https://doi.org/10.3390/v13020280 | |
| dc.identifier.uri | http://hdl.handle.net/11427/35272 | |
| dc.identifier.vancouvercitation | Taku O, Mbulawa ZZA, Phohlo K, Garcia-Jardon M, Businge CB, Williamson A. Distribution of Human Papillomavirus (HPV) Genotypes in HIV-Negative and HIV-Positive Women with Cervical Intraepithelial Lesions in the Eastern Cape Province, South Africa. Viruses. 2021;13(2) http://hdl.handle.net/11427/35272. | en_ZA |
| dc.language.iso | en | en_US |
| dc.publisher.department | Institute of Infectious Disease and Molecular Medicine | en_US |
| dc.publisher.faculty | Faculty of Health Sciences | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
| dc.source | Viruses | en_US |
| dc.source.journalissue | 2 | en_US |
| dc.source.journalvolume | 13 | en_US |
| dc.source.uri | https://www.mdpi.com/journal/viruses | |
| dc.subject | human papillomavirus | |
| dc.subject | human immunodeficiency virus | |
| dc.subject | cervical intraepithelial lesions | |
| dc.subject | South Africa | |
| dc.title | Distribution of Human Papillomavirus (HPV) Genotypes in HIV-Negative and HIV-Positive Women with Cervical Intraepithelial Lesions in the Eastern Cape Province, South Africa | en_US |
| dc.type | Journal Article | en_US |