Infrequent, low magnitude HIV-specific T cell responses in HIV-uninfected participants in the 1% tenofovir microbicide gel trial (CAPRISA004)

Simple item page
dc.contributor.authorBurgers, WAen_ZA
dc.contributor.authorMuller, TLen_ZA
dc.contributor.authorKiravu, Aen_ZA
dc.contributor.authorNaranbhai, Ven_ZA
dc.contributor.authorSibeko, Sen_ZA
dc.contributor.authorWerner, Len_ZA
dc.contributor.authorKarim, Qen_ZA
dc.contributor.authorKarim, SSen_ZA
dc.date.accessioned2015-11-18T03:46:56Z
dc.date.available2015-11-18T03:46:56Z
dc.date.issued2012en_ZA
dc.description.abstractMacaque studies of antiretroviral-containing microbicide gels administered rectally or vaginally followed by SIV challenge have documented priming of SIV-specific T cell responses in the blood of protected animals. This concept has been termed “chemo-vaccination”, where aborted viral replication is thought to leave an immune footprint of exposure, which may augment protection provided by microbicides/PrEP. We investigated whether T cell responses were detectable in women participating in CAPRISA004 1% tenofovir microbicide trial, which showed 39% efficacy in reducing HIV acquisition.en_ZA
dc.identifier.apacitationBurgers, W., Muller, T., Kiravu, A., Naranbhai, V., Sibeko, S., Werner, L., ... Karim, S. (2012). Infrequent, low magnitude HIV-specific T cell responses in HIV-uninfected participants in the 1% tenofovir microbicide gel trial (CAPRISA004). <i>Retrovirology</i>, http://hdl.handle.net/11427/15045en_ZA
dc.identifier.chicagocitationBurgers, WA, TL Muller, A Kiravu, V Naranbhai, S Sibeko, L Werner, Q Karim, and SS Karim "Infrequent, low magnitude HIV-specific T cell responses in HIV-uninfected participants in the 1% tenofovir microbicide gel trial (CAPRISA004)." <i>Retrovirology</i> (2012) http://hdl.handle.net/11427/15045en_ZA
dc.identifier.citationBurgers, W. A., Muller, T. L., Kiravu, A., Naranbhai, V., Sibeko, S., Werner, L., ... & Karim, S. A. (2012). Infrequent, low magnitude HIV-specific T cell responses in HIV-uninfected participants in the 1% tenofovir microbicide gel trial (CAPRISA004). Retrovirology, 9(Suppl 2), P225.en_ZA
dc.identifier.ris TY - Journal Article AU - Burgers, WA AU - Muller, TL AU - Kiravu, A AU - Naranbhai, V AU - Sibeko, S AU - Werner, L AU - Karim, Q AU - Karim, SS AB - Macaque studies of antiretroviral-containing microbicide gels administered rectally or vaginally followed by SIV challenge have documented priming of SIV-specific T cell responses in the blood of protected animals. This concept has been termed “chemo-vaccination”, where aborted viral replication is thought to leave an immune footprint of exposure, which may augment protection provided by microbicides/PrEP. We investigated whether T cell responses were detectable in women participating in CAPRISA004 1% tenofovir microbicide trial, which showed 39% efficacy in reducing HIV acquisition. DA - 2012 DB - OpenUCT DO - 10.1186/1742-4690-9-S2-P225 DP - University of Cape Town J1 - Retrovirology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Infrequent, low magnitude HIV-specific T cell responses in HIV-uninfected participants in the 1% tenofovir microbicide gel trial (CAPRISA004) TI - Infrequent, low magnitude HIV-specific T cell responses in HIV-uninfected participants in the 1% tenofovir microbicide gel trial (CAPRISA004) UR - http://hdl.handle.net/11427/15045 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15045
dc.identifier.urihttp://dx.doi.org/10.1186/1742-4690-9-S2-P225
dc.identifier.vancouvercitationBurgers W, Muller T, Kiravu A, Naranbhai V, Sibeko S, Werner L, et al. Infrequent, low magnitude HIV-specific T cell responses in HIV-uninfected participants in the 1% tenofovir microbicide gel trial (CAPRISA004). Retrovirology. 2012; http://hdl.handle.net/11427/15045.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Virologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2012 Burgers et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceRetrovirologyen_ZA
dc.source.urihttp://www.retrovirology.com/en_ZA
dc.subject.otherantiretroviral-containing microbicide gelsen_ZA
dc.titleInfrequent, low magnitude HIV-specific T cell responses in HIV-uninfected participants in the 1% tenofovir microbicide gel trial (CAPRISA004)en_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Burgers_HIV_T_cell_responses_2012.pdf
Size:
166.35 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles