Orthotopic liver transplantation at Groote Schuur Hospital : a serial analysis of biliary cytokines and biochemical parameters

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dc.contributor.authorSpearman, C W N
dc.date.accessioned2017-10-31T13:10:06Z
dc.date.available2017-10-31T13:10:06Z
dc.date.issued1991
dc.date.updated2017-06-06T10:15:22Z
dc.description.abstractOrthotopic liver transplantation is the treatment of choice for many patients with end-stage liver disease. Despite advances in immunosuppression, acute rejection remains common (up to 70%) and results in significant patient morbidity. It is frequently difficult to distinguish abnormal liver function due to rejection from that due to infection, biliary obstruction or ischaemic injury without performing invasive procedures such as a liver biopsy or angiography which may be Clinically, the diagnosis of rejection is usually once the immunological process is already hazardous. made late, established. In this study, we evaluated standard biochemical parameters and cytokine concentrations (IL-1, IL-6 and TNF-alpha) in serial samples of bile obtained post-operatively via the Ttubes of patients following orthotopic liver transplantation in order to determine whether there are any biochemical or immunological pointers to the early diagnosis of rejection which would enable earlier administration of appropriate antirejection therapy. Biliary cytokines did not prove to be useful and reliable markers of early rejection. Serial measurement of biliary bilirubin levels showed an early and significant decrease a few days prior to rejection, and were a more sensitive marker of graft function than serum bilirubin levels.
dc.identifier.apacitationSpearman, C. W. N. (1991). <i>Orthotopic liver transplantation at Groote Schuur Hospital : a serial analysis of biliary cytokines and biochemical parameters</i>. (). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/25952en_ZA
dc.identifier.chicagocitationSpearman, C W N. <i>"Orthotopic liver transplantation at Groote Schuur Hospital : a serial analysis of biliary cytokines and biochemical parameters."</i> ., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 1991. http://hdl.handle.net/11427/25952en_ZA
dc.identifier.citationSpearman, C. 1991. Orthotopic liver transplantation at Groote Schuur Hospital : a serial analysis of biliary cytokines and biochemical parameters. University of Cape Town.en_ZA
dc.identifier.risTY - Thesis / Dissertation AU - Spearman, C W N DA - 1991 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1991 T1 - Orthotopic liver transplantation at Groote Schuur Hospital : a serial analysis of biliary cytokines and biochemical parameters TI - Orthotopic liver transplantation at Groote Schuur Hospital : a serial analysis of biliary cytokines and biochemical parameters UR - http://hdl.handle.net/11427/25952 ER -en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/25952
dc.identifier.vancouvercitationSpearman CWN. Orthotopic liver transplantation at Groote Schuur Hospital : a serial analysis of biliary cytokines and biochemical parameters. []. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 1991 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/25952en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherBile - immunology
dc.subject.otherLiver Transplantation
dc.subject.otherTransplantation immunology
dc.titleOrthotopic liver transplantation at Groote Schuur Hospital : a serial analysis of biliary cytokines and biochemical parameters
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMed
uct.type.filetypeText
uct.type.filetypeImage
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