Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy
dc.contributor.author | Smith, Lara | en_ZA |
dc.contributor.author | Adnams, Colleen | en_ZA |
dc.contributor.author | Eley, Brian | en_ZA |
dc.date.accessioned | 2014-10-28T14:11:35Z | |
dc.date.available | 2014-10-28T14:11:35Z | |
dc.date.issued | 2008 | en_ZA |
dc.description.abstract | Aim: To describe neurological and neurocognitive deficits in HIV-infected children and the short-term effect of highly active antiretroviral therapy (HAART) on the observed deficits. Methods: In this prospective study, 39 children (15 females) were evaluated before the start of HAART and 30 reassessed 6 months later. The subjects were evaluated with a range of cognitive tests used in everyday clinical practice. Results: At enrolment, the mean (±SD) age was 60±46 months, 17 (44%) and 22 (56%) had Centers for Disease Control (CDC) clinical category B and C disease respectively, and 36 (92%) had severe immunosuppression. At the start of HAART no child had cranial nerve or cerebellar dysfunction, but 13/29 (33.3%) had evidence of motor dysfunction. By 6 months 1 child had developed cerebellar dysfunction, but there was no statistically significant change in the frequency of motor dysfunction. Mean baseline performances on cognitive testing were generally subnormal. Between 33% and 81% of the children recorded subnormal intelligence quotients on various cognitive tests. Mean performances did not change significantly after 6 months of HAART. Conclusion: Neurological and neurocognitive deficits are frequent in HIV-infected children. The prevalence and extent of deficits did not change significantly in response to short-term HAART, indicating neither spontaneous improvement nor deterioration during early treatment. | en_ZA |
dc.identifier.apacitation | Smith, L., Adnams, C., & Eley, B. (2008). Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy. <i>South African Journal of Child Health</i>, http://hdl.handle.net/11427/8879 | en_ZA |
dc.identifier.chicagocitation | Smith, Lara, Colleen Adnams, and Brian Eley "Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy." <i>South African Journal of Child Health</i> (2008) http://hdl.handle.net/11427/8879 | en_ZA |
dc.identifier.citation | Smith, L., Adnams, C., Eley, B. 2008. Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy. South African Journal of Child Health. | en_ZA |
dc.identifier.issn | 1999-7671 | en_ZA |
dc.identifier.ris | TY - Journal Article AU - Smith, Lara AU - Adnams, Colleen AU - Eley, Brian AB - Aim: To describe neurological and neurocognitive deficits in HIV-infected children and the short-term effect of highly active antiretroviral therapy (HAART) on the observed deficits. Methods: In this prospective study, 39 children (15 females) were evaluated before the start of HAART and 30 reassessed 6 months later. The subjects were evaluated with a range of cognitive tests used in everyday clinical practice. Results: At enrolment, the mean (±SD) age was 60±46 months, 17 (44%) and 22 (56%) had Centers for Disease Control (CDC) clinical category B and C disease respectively, and 36 (92%) had severe immunosuppression. At the start of HAART no child had cranial nerve or cerebellar dysfunction, but 13/29 (33.3%) had evidence of motor dysfunction. By 6 months 1 child had developed cerebellar dysfunction, but there was no statistically significant change in the frequency of motor dysfunction. Mean baseline performances on cognitive testing were generally subnormal. Between 33% and 81% of the children recorded subnormal intelligence quotients on various cognitive tests. Mean performances did not change significantly after 6 months of HAART. Conclusion: Neurological and neurocognitive deficits are frequent in HIV-infected children. The prevalence and extent of deficits did not change significantly in response to short-term HAART, indicating neither spontaneous improvement nor deterioration during early treatment. DA - 2008 DB - OpenUCT DP - University of Cape Town J1 - South African Journal of Child Health LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 SM - 1999-7671 T1 - Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy TI - Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy UR - http://hdl.handle.net/11427/8879 ER - | en_ZA |
dc.identifier.uri | http://hdl.handle.net/11427/8879 | |
dc.identifier.vancouvercitation | Smith L, Adnams C, Eley B. Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy. South African Journal of Child Health. 2008; http://hdl.handle.net/11427/8879. | en_ZA |
dc.language.iso | eng | en_ZA |
dc.publisher | Health & Medical Publishing Group | en_ZA |
dc.publisher.department | ADP: Health Sciences EDU | en_ZA |
dc.publisher.faculty | Centre for Higher Education Development | en_ZA |
dc.publisher.institution | University of Cape Town | |
dc.rights | Attribution-NonCommercial 3.0 Unported | en_ZA |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/ | en_ZA |
dc.source | South African Journal of Child Health | en_ZA |
dc.source.uri | http://www.sajch.org.za/index.php/SAJCH/article/view/115/68 | en_ZA |
dc.title | Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy | en_ZA |
dc.type | Journal Article | en_ZA |
uct.type.filetype | Text | |
uct.type.filetype | Image | |
uct.type.publication | Research | en_ZA |
uct.type.resource | Article | en_ZA |
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