Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy

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dc.contributor.authorSmith, Laraen_ZA
dc.contributor.authorAdnams, Colleenen_ZA
dc.contributor.authorEley, Brianen_ZA
dc.date.accessioned2014-10-28T14:11:35Z
dc.date.available2014-10-28T14:11:35Z
dc.date.issued2008en_ZA
dc.description.abstractAim: To describe neurological and neurocognitive deficits in HIV-infected children and the short-term effect of highly active antiretroviral therapy (HAART) on the observed deficits. Methods: In this prospective study, 39 children (15 females) were evaluated before the start of HAART and 30 reassessed 6 months later. The subjects were evaluated with a range of cognitive tests used in everyday clinical practice. Results: At enrolment, the mean (±SD) age was 60±46 months, 17 (44%) and 22 (56%) had Centers for Disease Control (CDC) clinical category B and C disease respectively, and 36 (92%) had severe immunosuppression. At the start of HAART no child had cranial nerve or cerebellar dysfunction, but 13/29 (33.3%) had evidence of motor dysfunction. By 6 months 1 child had developed cerebellar dysfunction, but there was no statistically significant change in the frequency of motor dysfunction. Mean baseline performances on cognitive testing were generally subnormal. Between 33% and 81% of the children recorded subnormal intelligence quotients on various cognitive tests. Mean performances did not change significantly after 6 months of HAART. Conclusion: Neurological and neurocognitive deficits are frequent in HIV-infected children. The prevalence and extent of deficits did not change significantly in response to short-term HAART, indicating neither spontaneous improvement nor deterioration during early treatment.en_ZA
dc.identifier.apacitationSmith, L., Adnams, C., & Eley, B. (2008). Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy. <i>South African Journal of Child Health</i>, http://hdl.handle.net/11427/8879en_ZA
dc.identifier.chicagocitationSmith, Lara, Colleen Adnams, and Brian Eley "Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy." <i>South African Journal of Child Health</i> (2008) http://hdl.handle.net/11427/8879en_ZA
dc.identifier.citationSmith, L., Adnams, C., Eley, B. 2008. Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy. South African Journal of Child Health.en_ZA
dc.identifier.issn1999-7671en_ZA
dc.identifier.ris TY - Journal Article AU - Smith, Lara AU - Adnams, Colleen AU - Eley, Brian AB - Aim: To describe neurological and neurocognitive deficits in HIV-infected children and the short-term effect of highly active antiretroviral therapy (HAART) on the observed deficits. Methods: In this prospective study, 39 children (15 females) were evaluated before the start of HAART and 30 reassessed 6 months later. The subjects were evaluated with a range of cognitive tests used in everyday clinical practice. Results: At enrolment, the mean (±SD) age was 60±46 months, 17 (44%) and 22 (56%) had Centers for Disease Control (CDC) clinical category B and C disease respectively, and 36 (92%) had severe immunosuppression. At the start of HAART no child had cranial nerve or cerebellar dysfunction, but 13/29 (33.3%) had evidence of motor dysfunction. By 6 months 1 child had developed cerebellar dysfunction, but there was no statistically significant change in the frequency of motor dysfunction. Mean baseline performances on cognitive testing were generally subnormal. Between 33% and 81% of the children recorded subnormal intelligence quotients on various cognitive tests. Mean performances did not change significantly after 6 months of HAART. Conclusion: Neurological and neurocognitive deficits are frequent in HIV-infected children. The prevalence and extent of deficits did not change significantly in response to short-term HAART, indicating neither spontaneous improvement nor deterioration during early treatment. DA - 2008 DB - OpenUCT DP - University of Cape Town J1 - South African Journal of Child Health LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 SM - 1999-7671 T1 - Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy TI - Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy UR - http://hdl.handle.net/11427/8879 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/8879
dc.identifier.vancouvercitationSmith L, Adnams C, Eley B. Neurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapy. South African Journal of Child Health. 2008; http://hdl.handle.net/11427/8879.en_ZA
dc.language.isoengen_ZA
dc.publisherHealth & Medical Publishing Groupen_ZA
dc.publisher.departmentADP: Health Sciences EDUen_ZA
dc.publisher.facultyCentre for Higher Education Developmenten_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsAttribution-NonCommercial 3.0 Unporteden_ZA
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en_ZA
dc.sourceSouth African Journal of Child Healthen_ZA
dc.source.urihttp://www.sajch.org.za/index.php/SAJCH/article/view/115/68en_ZA
dc.titleNeurological and neurocognitive function of HIV-infected children commenced on antiretroviral therapyen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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