Effects of diabetes mellitus on amyotrophic lateral sclerosis: a systematic review

dc.contributor.authorLekoubou, Alainen_ZA
dc.contributor.authorMatsha, Tandien_ZA
dc.contributor.authorSobngwi, Eugeneen_ZA
dc.contributor.authorKengne, Andreen_ZA
dc.date.accessioned2015-10-28T07:07:47Z
dc.date.available2015-10-28T07:07:47Z
dc.date.issued2014en_ZA
dc.description.abstractBACKGROUND:Amyotrophic lateral sclerosis (ALS) is an incurable motor neuron degenerative disease which onset and course may be affected by concurrent diabetes mellitus (DM). We performed a systematic review to assess the effect of DM/dysglycemic states on ALS. METHODS: We searched PubMed MEDLINE, from inception to March 2013 for original articles published in English and in French languages on DM (and related states) and ALS. We made no restriction per study designs. RESULTS: Seven studies/1410 citations (5 case-control and 2 cross-sectional) were included in the final selection. The number of participants with ALS ranged from 18 to 2371. The outcome of interest was ALS and DM/dysglycemic states respectively in three and two case control-studies. DM/impaired glucose tolerance status did not affect disease progression, survival, disease severity and disease duration in ALS participants but ALS participants with DM were found to be older in one study. DM/IGT prevalence was similar in both ALS and non ALS participants. This review was limited by the absence of prospective cohort studies and the heterogeneity in ALS and DM diagnosis criteria. CONCLUSIONS: This systematic review suggests that evidences for the association of ALS and DM are rather limited and derived from cross-sectional studies. Prospective studies supplemented by ALS registries and animal studies are needed to better understand the relationship between both conditions.en_ZA
dc.identifier.apacitationLekoubou, A., Matsha, T., Sobngwi, E., & Kengne, A. (2014). Effects of diabetes mellitus on amyotrophic lateral sclerosis: a systematic review. <i>BMC Research Notes</i>, http://hdl.handle.net/11427/14477en_ZA
dc.identifier.chicagocitationLekoubou, Alain, Tandi Matsha, Eugene Sobngwi, and Andre Kengne "Effects of diabetes mellitus on amyotrophic lateral sclerosis: a systematic review." <i>BMC Research Notes</i> (2014) http://hdl.handle.net/11427/14477en_ZA
dc.identifier.citationLekoubou, A., Matsha, T. E., Sobngwi, E., & Kengne, A. P. (2014). Effects of diabetes mellitus on amyotrophic lateral sclerosis: a systematic review. BMC research notes, 7(1), 171.en_ZA
dc.identifier.ris TY - Journal Article AU - Lekoubou, Alain AU - Matsha, Tandi AU - Sobngwi, Eugene AU - Kengne, Andre AB - BACKGROUND:Amyotrophic lateral sclerosis (ALS) is an incurable motor neuron degenerative disease which onset and course may be affected by concurrent diabetes mellitus (DM). We performed a systematic review to assess the effect of DM/dysglycemic states on ALS. METHODS: We searched PubMed MEDLINE, from inception to March 2013 for original articles published in English and in French languages on DM (and related states) and ALS. We made no restriction per study designs. RESULTS: Seven studies/1410 citations (5 case-control and 2 cross-sectional) were included in the final selection. The number of participants with ALS ranged from 18 to 2371. The outcome of interest was ALS and DM/dysglycemic states respectively in three and two case control-studies. DM/impaired glucose tolerance status did not affect disease progression, survival, disease severity and disease duration in ALS participants but ALS participants with DM were found to be older in one study. DM/IGT prevalence was similar in both ALS and non ALS participants. This review was limited by the absence of prospective cohort studies and the heterogeneity in ALS and DM diagnosis criteria. CONCLUSIONS: This systematic review suggests that evidences for the association of ALS and DM are rather limited and derived from cross-sectional studies. Prospective studies supplemented by ALS registries and animal studies are needed to better understand the relationship between both conditions. DA - 2014 DB - OpenUCT DO - 10.1186/1756-0500-7-171 DP - University of Cape Town J1 - BMC Research Notes LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Effects of diabetes mellitus on amyotrophic lateral sclerosis: a systematic review TI - Effects of diabetes mellitus on amyotrophic lateral sclerosis: a systematic review UR - http://hdl.handle.net/11427/14477 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14477
dc.identifier.urihttp://dx.doi.org/10.1186/1756-0500-7-171
dc.identifier.vancouvercitationLekoubou A, Matsha T, Sobngwi E, Kengne A. Effects of diabetes mellitus on amyotrophic lateral sclerosis: a systematic review. BMC Research Notes. 2014; http://hdl.handle.net/11427/14477.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2014 Lekoubou et al.; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceBMC Research Notesen_ZA
dc.source.urihttp://www.biomedcentral.com/bmcresnotes/en_ZA
dc.subject.otherAmyotrophic lateral sclerosisen_ZA
dc.subject.otherdiabetesen_ZA
dc.titleEffects of diabetes mellitus on amyotrophic lateral sclerosis: a systematic reviewen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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