An African perspective on the genetic risk of chronic kidney disease: a systematic review

Simple item page
dc.contributor.authorGeorge, Cindy
dc.contributor.authorYako, Yandiswa Y
dc.contributor.authorOkpechi, Ikechi G
dc.contributor.authorMatsha, Tandi E
dc.contributor.authorKaze Folefack, Francois J
dc.contributor.authorKengne, Andre P
dc.date.accessioned2018-10-22T10:00:48Z
dc.date.available2018-10-22T10:00:48Z
dc.date.issued2018-10-19
dc.date.updated2018-10-21T03:18:19Z
dc.description.abstractBackground Individuals of African ethnicity are disproportionately burdened with chronic kidney disease (CKD). However, despite the genetic link, genetic association studies of CKD in African populations are lacking. Methods We conducted a systematic review to critically evaluate the existing studies on CKD genetic risk inferred by polymorphism(s) amongst African populations in Africa. The study followed the HuGE handbook and PRISMA protocol. We included studies reporting on the association of polymorphism(s) with prevalent CKD, end-stage renaldisease (ESRD) or CKD-associated traits. Given the very few studies investigating the effects of the same single nucleotide polymorphisms (SNPs) on CKD risk, a narrative synthesis of the evidence was conducted. Results A total of 30 polymorphisms in 11 genes were investigated for their association with CKD, ESRD or related traits, all using the candidate-gene approach. Of all the included genes, MYH9, AT1R and MTHFR genes failed to predict CKD or related traits, while variants in the APOL1, apoE, eNOS, XPD, XRCC1, renalase, ADIPOQ, and CCR2 genes were associated with CKD or other related traits. Two SNPs (rs73885319, rs60910145) and haplotypes (G-A-G; G1; G2) of the apolipoprotein L1 (APOL1) gene were studied in more than one population group, with similar association with prevalent CKD observed. The remaining polymorphisms were investigated in single studies. Conclusion According to this systematic review, there is currently insufficient evidence of the specific polymorphisms that poses African populations at an increased risk of CKD. Large-scale genetic studies are warranted to better understand susceptibility polymorphisms, specific to African populations.
dc.identifier.apacitationGeorge, C., Yako, Y. Y., Okpechi, I. G., Matsha, T. E., Kaze Folefack, F. J., & Kengne, A. P. (2018). An African perspective on the genetic risk of chronic kidney disease: a systematic review. <i>BMC Medical Genetics</i>, http://hdl.handle.net/11427/28938en_ZA
dc.identifier.chicagocitationGeorge, Cindy, Yandiswa Y Yako, Ikechi G Okpechi, Tandi E Matsha, Francois J Kaze Folefack, and Andre P Kengne "An African perspective on the genetic risk of chronic kidney disease: a systematic review." <i>BMC Medical Genetics</i> (2018) http://hdl.handle.net/11427/28938en_ZA
dc.identifier.citationGeorge, C., Yako, Y. Y., Okpechi, I. G., Matsha, T. E., Kaze Folefack, F. J., & Kengne, A. P. 2018. BMC Medical Genetics. 19(1):187.
dc.identifier.ris TY - Journal Article AU - George, Cindy AU - Yako, Yandiswa Y AU - Okpechi, Ikechi G AU - Matsha, Tandi E AU - Kaze Folefack, Francois J AU - Kengne, Andre P AB - Background Individuals of African ethnicity are disproportionately burdened with chronic kidney disease (CKD). However, despite the genetic link, genetic association studies of CKD in African populations are lacking. Methods We conducted a systematic review to critically evaluate the existing studies on CKD genetic risk inferred by polymorphism(s) amongst African populations in Africa. The study followed the HuGE handbook and PRISMA protocol. We included studies reporting on the association of polymorphism(s) with prevalent CKD, end-stage renaldisease (ESRD) or CKD-associated traits. Given the very few studies investigating the effects of the same single nucleotide polymorphisms (SNPs) on CKD risk, a narrative synthesis of the evidence was conducted. Results A total of 30 polymorphisms in 11 genes were investigated for their association with CKD, ESRD or related traits, all using the candidate-gene approach. Of all the included genes, MYH9, AT1R and MTHFR genes failed to predict CKD or related traits, while variants in the APOL1, apoE, eNOS, XPD, XRCC1, renalase, ADIPOQ, and CCR2 genes were associated with CKD or other related traits. Two SNPs (rs73885319, rs60910145) and haplotypes (G-A-G; G1; G2) of the apolipoprotein L1 (APOL1) gene were studied in more than one population group, with similar association with prevalent CKD observed. The remaining polymorphisms were investigated in single studies. Conclusion According to this systematic review, there is currently insufficient evidence of the specific polymorphisms that poses African populations at an increased risk of CKD. Large-scale genetic studies are warranted to better understand susceptibility polymorphisms, specific to African populations. DA - 2018-10-19 DB - OpenUCT DP - University of Cape Town J1 - BMC Medical Genetics LK - https://open.uct.ac.za PB - University of Cape Town PY - 2018 T1 - An African perspective on the genetic risk of chronic kidney disease: a systematic review TI - An African perspective on the genetic risk of chronic kidney disease: a systematic review UR - http://hdl.handle.net/11427/28938 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s12881-018-0702-x
dc.identifier.urihttp://hdl.handle.net/11427/28938
dc.identifier.vancouvercitationGeorge C, Yako YY, Okpechi IG, Matsha TE, Kaze Folefack FJ, Kengne AP. An African perspective on the genetic risk of chronic kidney disease: a systematic review. BMC Medical Genetics. 2018; http://hdl.handle.net/11427/28938.en_ZA
dc.language.isoen
dc.publisherBioMed Central
dc.publisher.departmentDivision of Nephrology and Hypertensionen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rights.holderThe Author(s).
dc.sourceBMC Medical Genetics
dc.source.urihttps://bmcmedgenet.biomedcentral.com/
dc.subject.otherChronic kidney disease
dc.subject.otherEnd-stage renal disease
dc.subject.otherGenetics
dc.subject.otherAfrica
dc.titleAn African perspective on the genetic risk of chronic kidney disease: a systematic review
dc.typeJournal Article
uct.type.filetypeText
uct.type.filetypeImage
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
George_2018_Article.pdf
Size:
783.92 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.72 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles