Investment case for malaria elimination in South Africa: a financing model for resource mobilization to accelerate regional malaria elimination

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dc.contributor.authorNjau, Joseph
dc.contributor.authorSilal, Sheetal P.
dc.contributor.authorKollipara, Aparna
dc.contributor.authorFox, Katie
dc.contributor.authorBalawanth, Ryleen
dc.contributor.authorYuen, Anthony
dc.contributor.authorWhite, Lisa J.
dc.contributor.authorMoya, Mandisi
dc.contributor.authorPillay, Yogan
dc.contributor.authorMoonasar, Devanand
dc.date.accessioned2021-10-07T07:18:12Z
dc.date.available2021-10-07T07:18:12Z
dc.date.issued2021-08-16
dc.date.updated2021-08-22T03:09:44Z
dc.description.abstractBackground Malaria continues to be a public health problem in South Africa. While the disease is mainly confined to three of the nine provinces, most local transmissions occur because of importation of cases from neighbouring countries. The government of South Africa has reiterated its commitment to eliminate malaria within its borders. To support the achievement of this goal, this study presents a cost–benefit analysis of malaria elimination in South Africa through simulating different scenarios aimed at achieving malaria elimination within a 10-year period. Methods A dynamic mathematical transmission model was developed to estimate the costs and benefits of malaria elimination in South Africa between 2018 and 2030. The model simulated a range of malaria interventions and estimated their impact on the transmission of Plasmodium falciparum malaria between 2018 and 2030 in the three endemic provinces of Limpopo, Mpumalanga and KwaZulu-Natal. Local financial, economic, and epidemiological data were used to calibrate the transmission model. Results Based on the three primary simulated scenarios: Business as Usual, Accelerate and Source Reduction, the total economic burden was estimated as follows: for the Business as Usual scenario, the total economic burden of malaria in South Africa was R 3.69 billion (USD 223.3 million) over an 11-year period (2018–2029). The economic burden of malaria was estimated at R4.88 billion (USD 295.5 million) and R6.34 billion (~ USD 384 million) for the Accelerate and Source Reduction scenarios, respectively. Costs and benefits are presented in midyear 2020 values. Malaria elimination was predicted to occur in all three provinces if the Source Reduction strategy was adopted to help reduce malaria rates in southern Mozambique. This could be achieved by limiting annual local incidence in South Africa to less than 1 indigenous case with a prediction of this goal being achieved by the year 2026. Conclusions Malaria elimination in South Africa is feasible and economically worthwhile with a guaranteed positive return on investment (ROI). Findings of this study show that through securing funding for the proposed malaria interventions in the endemic areas of South Africa and neighbouring Mozambique, national elimination could be within reach in an 8-year period.en_US
dc.identifier.apacitationNjau, J., Silal, Sheetal P., Kollipara, A., Fox, K., Balawanth, R., Yuen, A., ... Moonasar, D. (2021). Investment case for malaria elimination in South Africa: a financing model for resource mobilization to accelerate regional malaria elimination. <i>Malaria Journal</i>, 20(Article number: 344), http://hdl.handle.net/11427/34102en_ZA
dc.identifier.chicagocitationNjau, Joseph, Sheetal P. Silal, Aparna Kollipara, Katie Fox, Ryleen Balawanth, Anthony Yuen, Lisa J. White, Mandisi Moya, Yogan Pillay, and Devanand Moonasar "Investment case for malaria elimination in South Africa: a financing model for resource mobilization to accelerate regional malaria elimination." <i>Malaria Journal</i> 20, Article number: 344. (2021) http://hdl.handle.net/11427/34102en_ZA
dc.identifier.citationNjau, J., Silal, Sheetal P., Kollipara, A., Fox, K., Balawanth, R., Yuen, A., White, Lisa J. & Moya, M. et al. 2021. Investment case for malaria elimination in South Africa: a financing model for resource mobilization to accelerate regional malaria elimination. <i>Malaria Journal.</i> 20(Article number: 344) http://hdl.handle.net/11427/34102en_ZA
dc.identifier.ris TY - Journal Article AU - Njau, Joseph AU - Silal, Sheetal P. AU - Kollipara, Aparna AU - Fox, Katie AU - Balawanth, Ryleen AU - Yuen, Anthony AU - White, Lisa J. AU - Moya, Mandisi AU - Pillay, Yogan AU - Moonasar, Devanand AB - Background Malaria continues to be a public health problem in South Africa. While the disease is mainly confined to three of the nine provinces, most local transmissions occur because of importation of cases from neighbouring countries. The government of South Africa has reiterated its commitment to eliminate malaria within its borders. To support the achievement of this goal, this study presents a cost–benefit analysis of malaria elimination in South Africa through simulating different scenarios aimed at achieving malaria elimination within a 10-year period. Methods A dynamic mathematical transmission model was developed to estimate the costs and benefits of malaria elimination in South Africa between 2018 and 2030. The model simulated a range of malaria interventions and estimated their impact on the transmission of Plasmodium falciparum malaria between 2018 and 2030 in the three endemic provinces of Limpopo, Mpumalanga and KwaZulu-Natal. Local financial, economic, and epidemiological data were used to calibrate the transmission model. Results Based on the three primary simulated scenarios: Business as Usual, Accelerate and Source Reduction, the total economic burden was estimated as follows: for the Business as Usual scenario, the total economic burden of malaria in South Africa was R 3.69 billion (USD 223.3 million) over an 11-year period (2018–2029). The economic burden of malaria was estimated at R4.88 billion (USD 295.5 million) and R6.34 billion (~ USD 384 million) for the Accelerate and Source Reduction scenarios, respectively. Costs and benefits are presented in midyear 2020 values. Malaria elimination was predicted to occur in all three provinces if the Source Reduction strategy was adopted to help reduce malaria rates in southern Mozambique. This could be achieved by limiting annual local incidence in South Africa to less than 1 indigenous case with a prediction of this goal being achieved by the year 2026. Conclusions Malaria elimination in South Africa is feasible and economically worthwhile with a guaranteed positive return on investment (ROI). Findings of this study show that through securing funding for the proposed malaria interventions in the endemic areas of South Africa and neighbouring Mozambique, national elimination could be within reach in an 8-year period. DA - 2021-08-16 DB - OpenUCT DP - University of Cape Town IS - Article number: 344 J1 - Malaria Journal LK - https://open.uct.ac.za PY - 2021 T1 - Investment case for malaria elimination in South Africa: a financing model for resource mobilization to accelerate regional malaria elimination TI - Investment case for malaria elimination in South Africa: a financing model for resource mobilization to accelerate regional malaria elimination UR - http://hdl.handle.net/11427/34102 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s12936-021-03875-z
dc.identifier.urihttp://hdl.handle.net/11427/34102
dc.identifier.vancouvercitationNjau J, Silal Sheetal P, Kollipara A, Fox K, Balawanth R, Yuen A, et al. Investment case for malaria elimination in South Africa: a financing model for resource mobilization to accelerate regional malaria elimination. Malaria Journal. 2021;20(Article number: 344) http://hdl.handle.net/11427/34102.en_ZA
dc.language.isoenen_US
dc.language.rfc3066en
dc.publisher.departmentDepartment of Statistical Sciencesen_US
dc.publisher.facultyFaculty of Scienceen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceMalaria Journalen_US
dc.source.journalissueArticle number: 344en_US
dc.source.journalvolume20en_US
dc.source.urihttps://malariajournal.biomedcentral.com/
dc.titleInvestment case for malaria elimination in South Africa: a financing model for resource mobilization to accelerate regional malaria eliminationen_US
dc.typeJournal Articleen_US
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