Is air pollution a risk factor for rheumatoid arthritis?

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dc.contributor.authorEssouma, Mickael
dc.contributor.authorNoubiap, Jean Jacques N
dc.date.accessioned2021-10-08T07:08:14Z
dc.date.available2021-10-08T07:08:14Z
dc.date.issued2015
dc.description.abstractRheumatoid arthritis is a chronic inflammatory debilitating disease triggered by a complex interaction involving genetic and environmental factors. Active smoking and occupational exposures such as silica increase its risk, suggesting that initial inflammation and generation of rheumatoid arthritis-related autoantibodies in the lungs may precede the clinical disease. This hypothesis paved the way to epidemiological studies investigating air pollution as a potential determinant of rheumatoid arthritis. Studies designed for epidemiology of rheumatoid arthritis found a link between traffic, a surrogate of air pollution, and this disease. Furthermore, a small case–control study recently found an association between wood smoke exposure and anticyclic citrullinated protein/peptide antibody in sera of patients presenting wood-smoke-related chronic obstructive pulmonary disease. However, reports addressing impact of specific pollutants on rheumatoid arthritis incidence and severity across populations are somewhat conflicting. In addition to the link reported between other systemic autoimmune rheumatic diseases and particulate matters/gaseous pollutants, experimental observation of exacerbated rheumatoid arthritis incidence and severity in mice models of collagen-induced arthritis after diesel exhaust particles exposure as well as hypovitaminosis D-related autoimmunity can help understand the role of air pollution in rheumatoid arthritis. All these considerations highlight the necessity to extend high quality epidemiological researches investigating different sources of atmospheric pollution across populations and particularly in low-and-middle countries, in order to further explore the biological plausibility of air pollution’s effect in the pathogenesis of rheumatoid arthritis. This should be attempted to better inform policies aiming to reduce the burden of rheumatoid arthritis.
dc.identifier.apacitationEssouma, M., & Noubiap, J. J. N. (2015). Is air pollution a risk factor for rheumatoid arthritis?. <i>Journal of Inflammation (London)</i>, 12(1), 174 - 177. http://hdl.handle.net/11427/34530en_ZA
dc.identifier.chicagocitationEssouma, Mickael, and Jean Jacques N Noubiap "Is air pollution a risk factor for rheumatoid arthritis?." <i>Journal of Inflammation (London)</i> 12, 1. (2015): 174 - 177. http://hdl.handle.net/11427/34530en_ZA
dc.identifier.citationEssouma, M. & Noubiap, J.J.N. 2015. Is air pollution a risk factor for rheumatoid arthritis?. <i>Journal of Inflammation (London).</i> 12(1):174 - 177. http://hdl.handle.net/11427/34530en_ZA
dc.identifier.issn1476-9255
dc.identifier.ris TY - Journal Article AU - Essouma, Mickael AU - Noubiap, Jean Jacques N AB - Rheumatoid arthritis is a chronic inflammatory debilitating disease triggered by a complex interaction involving genetic and environmental factors. Active smoking and occupational exposures such as silica increase its risk, suggesting that initial inflammation and generation of rheumatoid arthritis-related autoantibodies in the lungs may precede the clinical disease. This hypothesis paved the way to epidemiological studies investigating air pollution as a potential determinant of rheumatoid arthritis. Studies designed for epidemiology of rheumatoid arthritis found a link between traffic, a surrogate of air pollution, and this disease. Furthermore, a small case–control study recently found an association between wood smoke exposure and anticyclic citrullinated protein/peptide antibody in sera of patients presenting wood-smoke-related chronic obstructive pulmonary disease. However, reports addressing impact of specific pollutants on rheumatoid arthritis incidence and severity across populations are somewhat conflicting. In addition to the link reported between other systemic autoimmune rheumatic diseases and particulate matters/gaseous pollutants, experimental observation of exacerbated rheumatoid arthritis incidence and severity in mice models of collagen-induced arthritis after diesel exhaust particles exposure as well as hypovitaminosis D-related autoimmunity can help understand the role of air pollution in rheumatoid arthritis. All these considerations highlight the necessity to extend high quality epidemiological researches investigating different sources of atmospheric pollution across populations and particularly in low-and-middle countries, in order to further explore the biological plausibility of air pollution’s effect in the pathogenesis of rheumatoid arthritis. This should be attempted to better inform policies aiming to reduce the burden of rheumatoid arthritis. DA - 2015 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Journal of Inflammation (London) LK - https://open.uct.ac.za PY - 2015 SM - 1476-9255 T1 - Is air pollution a risk factor for rheumatoid arthritis? TI - Is air pollution a risk factor for rheumatoid arthritis? UR - http://hdl.handle.net/11427/34530 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34530
dc.identifier.vancouvercitationEssouma M, Noubiap JJN. Is air pollution a risk factor for rheumatoid arthritis?. Journal of Inflammation (London). 2015;12(1):174 - 177. http://hdl.handle.net/11427/34530.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceJournal of Inflammation (London)
dc.source.journalissue1
dc.source.journalvolume12
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1186/s12950-015-0092-1
dc.subject.otherInflammation
dc.subject.otherArthritis, Experimental
dc.subject.otherPulmonary Disease, Chronic Obstructive
dc.subject.otherArthritis, Rheumatoid
dc.subject.otherAutoimmune Diseases
dc.subject.otherWood
dc.subject.otherLung
dc.subject.otherProteins
dc.subject.otherParticulate Matter
dc.subject.otherAutoantibodies
dc.subject.otherVehicle Emissions
dc.subject.otherAntibodies
dc.subject.otherPeptides
dc.subject.otherSmoke
dc.subject.otherAir
dc.subject.otherAutoimmunity
dc.subject.otherRisk Factors
dc.subject.otherIncidence
dc.subject.otherCase-Control Studies
dc.subject.otherRisk
dc.subject.otherEpidemiologic Studies
dc.subject.otherMus musculus
dc.subject.otherMolecular Medicine
dc.subject.otherImmunology
dc.subject.otherPharmacology/Toxicology
dc.titleIs air pollution a risk factor for rheumatoid arthritis?
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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