The neurobiology of HIV dementia: implications for practice in South Africa
| dc.contributor.author | Joska, J A | |
| dc.contributor.author | Hoare, J | |
| dc.contributor.author | Stein, Dan J | |
| dc.contributor.author | Flisher, A J | |
| dc.date.accessioned | 2016-04-19T13:13:44Z | |
| dc.date.available | 2016-04-19T13:13:44Z | |
| dc.date.issued | 2011 | |
| dc.date.updated | 2016-01-07T08:27:23Z | |
| dc.description.abstract | In this review, the neuropathogenesis of HIV dementia (HIV-D) is discussed in the context of the local epidemic. HIV-D continues to be prevalent in the era of highly active anti-retroviral therapy. HIV neuro-invasion into the central nervous system may result in the development of separate HIV genotypes in an individual through compartmentalisation. The blood brain barrier continues to limit penetration of anti-retroviral drugs into the cerebrospinal fluid. Individuals with active neuro-inflammation appear to respond well to HAART. In some cases low grade neuro-degeneration persists with consequent clinical deterioration. In South Africa, the emergence of a sub-epidemic of HIV-D is being driven by various factors, including the incomplete coverage of HAART to all who need it, the late stage presentation of people living with HIV/AIDS (PLWHA) and a co-occurring methamphetamine epidemic. Differences in viral subtype do not appear to confer protection against HIV-D. Implications for PLWHA who are at risk for HIV-D in South Africa are explored, with a view to providing suggestions for improving practice and research into this area. | en_ZA |
| dc.identifier.apacitation | Joska, J. A., Hoare, J., Stein, D. J., & Flisher, A. J. (2011). The neurobiology of HIV dementia: implications for practice in South Africa. <i>African Journal of Psychiatry</i>, http://hdl.handle.net/11427/18987 | en_ZA |
| dc.identifier.chicagocitation | Joska, J A, J Hoare, Dan J Stein, and A J Flisher "The neurobiology of HIV dementia: implications for practice in South Africa." <i>African Journal of Psychiatry</i> (2011) http://hdl.handle.net/11427/18987 | en_ZA |
| dc.identifier.citation | Joska, J. A., Hoare, J., Stein, D. J., & Flisher, A. J. (2011). The neurobiology of HIV dementia: implications for practice in South Africa. African Journal of Psychiatry, 14(1). | en_ZA |
| dc.identifier.issn | 1994-8220 | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - Joska, J A AU - Hoare, J AU - Stein, Dan J AU - Flisher, A J AB - In this review, the neuropathogenesis of HIV dementia (HIV-D) is discussed in the context of the local epidemic. HIV-D continues to be prevalent in the era of highly active anti-retroviral therapy. HIV neuro-invasion into the central nervous system may result in the development of separate HIV genotypes in an individual through compartmentalisation. The blood brain barrier continues to limit penetration of anti-retroviral drugs into the cerebrospinal fluid. Individuals with active neuro-inflammation appear to respond well to HAART. In some cases low grade neuro-degeneration persists with consequent clinical deterioration. In South Africa, the emergence of a sub-epidemic of HIV-D is being driven by various factors, including the incomplete coverage of HAART to all who need it, the late stage presentation of people living with HIV/AIDS (PLWHA) and a co-occurring methamphetamine epidemic. Differences in viral subtype do not appear to confer protection against HIV-D. Implications for PLWHA who are at risk for HIV-D in South Africa are explored, with a view to providing suggestions for improving practice and research into this area. DA - 2011 DB - OpenUCT DP - University of Cape Town J1 - African Journal of Psychiatry LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 SM - 1994-8220 T1 - The neurobiology of HIV dementia: implications for practice in South Africa TI - The neurobiology of HIV dementia: implications for practice in South Africa UR - http://hdl.handle.net/11427/18987 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/18987 | |
| dc.identifier.vancouvercitation | Joska JA, Hoare J, Stein DJ, Flisher AJ. The neurobiology of HIV dementia: implications for practice in South Africa. African Journal of Psychiatry. 2011; http://hdl.handle.net/11427/18987. | en_ZA |
| dc.language | eng | en_ZA |
| dc.publisher | OMICS International | en_ZA |
| dc.publisher.department | Department of Psychiatry and Mental Health | en_ZA |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.source | African Journal of Psychiatry | en_ZA |
| dc.source.uri | http://www.ajol.info/index.php/ajpsy | |
| dc.subject.other | Dementia | |
| dc.subject.other | HIV | |
| dc.subject.other | HAART | |
| dc.subject.other | South Africa | |
| dc.title | The neurobiology of HIV dementia: implications for practice in South Africa | en_ZA |
| dc.type | Journal Article | en_ZA |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |