Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum

Simple item page
dc.contributor.advisorHoppe, Heinrich Cen_ZA
dc.contributor.authorSmythe, Wynand Antonen_ZA
dc.date.accessioned2014-07-28T18:20:52Z
dc.date.available2014-07-28T18:20:52Z
dc.date.issued2007en_ZA
dc.descriptionIncludes bibliographical references (leaves 94-103).
dc.description.abstractBy contrast to mammalian cells, very little is known about endocytosis in the malaria parasite. However, endocytosis via the cytostome is required by the parasite to ingest haemoglobin from its host cytosol which it transports within double membrane vesicles to the digestive vacuole, where digestion occurs and metabolites are used mostly for nutritional purposes. To gain a deeper understanding of the molecular basis and mechanisms of this vital process, a panel of inhibitors was used to inhibit the actin cytoskeleton and PI (3) kinases in the parasite. In this study Cytochalasin D and Latrunculin A, which depolymerise and prevent actin fimalment formation, Jasplakinolide, which stabilises actin filaments, and Wormannin and LY294002, which inhibit PI 93) kinase, were used to study actin disrupting and PI (3) kinase inhibiting drug effects on haemoglobin endocytosis and transport vesicle trafficking within the malaria parasite Plasmodium falciparum.en_ZA
dc.identifier.apacitationSmythe, W. A. (2007). <i>Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology. Retrieved from http://hdl.handle.net/11427/3301en_ZA
dc.identifier.chicagocitationSmythe, Wynand Anton. <i>"Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2007. http://hdl.handle.net/11427/3301en_ZA
dc.identifier.citationSmythe, W. 2007. Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Smythe, Wynand Anton AB - By contrast to mammalian cells, very little is known about endocytosis in the malaria parasite. However, endocytosis via the cytostome is required by the parasite to ingest haemoglobin from its host cytosol which it transports within double membrane vesicles to the digestive vacuole, where digestion occurs and metabolites are used mostly for nutritional purposes. To gain a deeper understanding of the molecular basis and mechanisms of this vital process, a panel of inhibitors was used to inhibit the actin cytoskeleton and PI (3) kinases in the parasite. In this study Cytochalasin D and Latrunculin A, which depolymerise and prevent actin fimalment formation, Jasplakinolide, which stabilises actin filaments, and Wormannin and LY294002, which inhibit PI 93) kinase, were used to study actin disrupting and PI (3) kinase inhibiting drug effects on haemoglobin endocytosis and transport vesicle trafficking within the malaria parasite Plasmodium falciparum. DA - 2007 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 T1 - Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum TI - Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum UR - http://hdl.handle.net/11427/3301 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3301
dc.identifier.vancouvercitationSmythe WA. Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2007 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3301en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Clinical Pharmacologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPharmacologyen_ZA
dc.titleCharacterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparumen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_hsf_2007_smythe_w.pdf
Size:
14.7 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Masters