Hepatitis C virus infection rate in volunteer blood donors from the Western Cape : comparison of screening tests and PCR

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dc.contributor.authorTucker, TJ
dc.contributor.authorVoigt, M
dc.contributor.authorBird, A
dc.contributor.authorROBSON, S
dc.contributor.authorGibbs, B
dc.contributor.authorKANNEMEYER, J
dc.contributor.authorGalloway, M
dc.contributor.authorKirsch, AE
dc.contributor.authorSMUTS, H
dc.date.accessioned2021-10-08T07:17:53Z
dc.date.available2021-10-08T07:17:53Z
dc.date.issued1997
dc.description.abstractINTRODUCTION: Hepatitis C virus (HCV) antibody seroprevalence studies overestimate the true infection rate. No data exist on the incidence of HCV or its clinical features in blood donors of sub-Saharan Africa. AIMS: To establish the true incidence of HCV infection in volunteer blood donors in the Western Cape, and compare risk factors and clinical and biochemical features of viraemic and non-viraemic subjects. METHODS: All donors attending the Western Province Blood Transfusion Service between December 1992 and August 1994 were screened prospectively for anti-HCV using the Abbott second-generation assay. Positive donors were evaluated clinically and biochemically. Their sera were examined for HCV-RNA by the polymerase chain reaction (PCR). RESULTS: Of 66314 donors screened, 275 (0.41%) were anti-HCV-positive. Of these 13.6% were PCR-positive (0.056% of all donors). PCR-positive patients had more risk factors for HCV acquisition (P < 0.01), symptoms of hepatitis (P = 0.02) and clinical signs of liver disease (P = 0.05) and higher alanine (P < 0.0001) and aspartate aminotransferase levels (P < 0.0001) than PCR-negative donors. However, clinical and biochemical features did not discriminate adequately between PCR-positive and negative donors. Liver biopsies performed in 9 of 13 PCR-positive cases showed mild inflammation, but no cirrhosis.
dc.identifier.apacitationTucker, T., Voigt, M., Bird, A., ROBSON, S., Gibbs, B., KANNEMEYER, J., ... SMUTS, H. (1997). Hepatitis C virus infection rate in volunteer blood donors from the Western Cape : comparison of screening tests and PCR. <i>South African Medical Journal</i>, 87(5), 603 - 605. http://hdl.handle.net/11427/34850en_ZA
dc.identifier.chicagocitationTucker, TJ, M Voigt, A Bird, S ROBSON, B Gibbs, J KANNEMEYER, M Galloway, AE Kirsch, and H SMUTS "Hepatitis C virus infection rate in volunteer blood donors from the Western Cape : comparison of screening tests and PCR." <i>South African Medical Journal</i> 87, 5. (1997): 603 - 605. http://hdl.handle.net/11427/34850en_ZA
dc.identifier.citationTucker, T., Voigt, M., Bird, A., ROBSON, S., Gibbs, B., KANNEMEYER, J., Galloway, M. & Kirsch, A. et al. 1997. Hepatitis C virus infection rate in volunteer blood donors from the Western Cape : comparison of screening tests and PCR. <i>South African Medical Journal.</i> 87(5):603 - 605. http://hdl.handle.net/11427/34850en_ZA
dc.identifier.issn0038-2469
dc.identifier.ris TY - Journal Article AU - Tucker, TJ AU - Voigt, M AU - Bird, A AU - ROBSON, S AU - Gibbs, B AU - KANNEMEYER, J AU - Galloway, M AU - Kirsch, AE AU - SMUTS, H AB - INTRODUCTION: Hepatitis C virus (HCV) antibody seroprevalence studies overestimate the true infection rate. No data exist on the incidence of HCV or its clinical features in blood donors of sub-Saharan Africa. AIMS: To establish the true incidence of HCV infection in volunteer blood donors in the Western Cape, and compare risk factors and clinical and biochemical features of viraemic and non-viraemic subjects. METHODS: All donors attending the Western Province Blood Transfusion Service between December 1992 and August 1994 were screened prospectively for anti-HCV using the Abbott second-generation assay. Positive donors were evaluated clinically and biochemically. Their sera were examined for HCV-RNA by the polymerase chain reaction (PCR). RESULTS: Of 66314 donors screened, 275 (0.41%) were anti-HCV-positive. Of these 13.6% were PCR-positive (0.056% of all donors). PCR-positive patients had more risk factors for HCV acquisition (P < 0.01), symptoms of hepatitis (P = 0.02) and clinical signs of liver disease (P = 0.05) and higher alanine (P < 0.0001) and aspartate aminotransferase levels (P < 0.0001) than PCR-negative donors. However, clinical and biochemical features did not discriminate adequately between PCR-positive and negative donors. Liver biopsies performed in 9 of 13 PCR-positive cases showed mild inflammation, but no cirrhosis. DA - 1997 DB - OpenUCT DP - University of Cape Town IS - 5 J1 - South African Medical Journal LK - https://open.uct.ac.za PY - 1997 SM - 0038-2469 T1 - Hepatitis C virus infection rate in volunteer blood donors from the Western Cape : comparison of screening tests and PCR TI - Hepatitis C virus infection rate in volunteer blood donors from the Western Cape : comparison of screening tests and PCR UR - http://hdl.handle.net/11427/34850 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34850
dc.identifier.vancouvercitationTucker T, Voigt M, Bird A, ROBSON S, Gibbs B, KANNEMEYER J, et al. Hepatitis C virus infection rate in volunteer blood donors from the Western Cape : comparison of screening tests and PCR. South African Medical Journal. 1997;87(5):603 - 605. http://hdl.handle.net/11427/34850.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceSouth African Medical Journal
dc.source.journalissue5
dc.source.journalvolume87
dc.source.pagination603 - 605
dc.source.urihttps://dx.doi.org/10.7196/sajs.718
dc.subject.otherViral hepatitis C
dc.subject.otherHepatitis C virus
dc.subject.otherPrevalence
dc.subject.otherSerology
dc.subject.otherAntibody
dc.subject.otherComparative study
dc.subject.otherPolymerase chain reaction
dc.subject.otherScreening test
dc.subject.otherHuman
dc.subject.otherBlood donor
dc.subject.otherMedical screening
dc.subject.otherSouth Africa
dc.subject.otherViral disease
dc.subject.otherInfection
dc.subject.otherFlaviviridae
dc.subject.otherVirus
dc.subject.otherDigestive diseases
dc.subject.otherHepatic disease
dc.subject.otherAfrica
dc.subject.otherHépatite virale C
dc.subject.otherVirus hépatite C
dc.subject.otherPrévalence
dc.titleHepatitis C virus infection rate in volunteer blood donors from the Western Cape : comparison of screening tests and PCR
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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