Anti-retroviral therapy increases the prevalence of dyslipidemia in South African HIV-infected patients

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dc.contributor.authorDave, Joel Aen_ZA
dc.contributor.authorLevitt, Naomi Sen_ZA
dc.contributor.authorRoss, Ian Len_ZA
dc.contributor.authorLacerda, Miguelen_ZA
dc.contributor.authorMaartens, Garyen_ZA
dc.contributor.authorBlom, Dirken_ZA
dc.date.accessioned2016-04-13T12:34:59Z
dc.date.available2016-04-13T12:34:59Z
dc.date.issued2016en_ZA
dc.description.abstractPurpose Data on the prevalence of dyslipidaemia and associated risk factors in HIV-infected patients from sub-Saharan Africa is sparse. We performed a cross-sectional analysis in a cohort of HIV-infected South African adults. METHODS: We studied HIV-infected patients who were either antiretroviral therapy (ART)-naive or receiving non-nucleoside reverse transcriptase inhibitor (NNRTI)-based or protease inhibitor (PI)-based ART. Evaluation included fasting lipograms, oral glucose tolerance tests and clinical anthropometry. Dyslipidemia was defined using the NCEP ATPIII guidelines. RESULTS: The median age of the participants was 34 years (range 19-68 years) and 78% were women. The prevalence of dyslipidemia in 406 ART-naive and 551 participants on ART was 90.0% and 85%, respectively. Low HDL-cholesterol (HDLC) was the most common abnormality [290/406 (71%) ART-naïve and 237/551 (43%) ART- participants]. Participants on ART had higher triglycerides (TG), total cholesterol (TC), LDL-cholesterol (LDLC) and HDLC than the ART-naïve group. Severe dyslipidaemia, (LDLC> 4.9 mmol/L or TG >5.0 mmol/L) was present in <5% of participants. In multivariate analyses there were complex associations between age, gender, type and duration of ART and body composition and LDLC, HDLC and TG, which differed between ART-naïve and ART-participants. CONCLUSION: Participants on ART had higher TG, TC, LDLC and HDLC than those who were ART-naïve but severe lipid abnormalities requiring evaluation and treatment were uncommon.en_ZA
dc.identifier.apacitationDave, J. A., Levitt, N. S., Ross, I. L., Lacerda, M., Maartens, G., & Blom, D. (2016). Anti-retroviral therapy increases the prevalence of dyslipidemia in South African HIV-infected patients. <i>PLoS One</i>, http://hdl.handle.net/11427/18851en_ZA
dc.identifier.chicagocitationDave, Joel A, Naomi S Levitt, Ian L Ross, Miguel Lacerda, Gary Maartens, and Dirk Blom "Anti-retroviral therapy increases the prevalence of dyslipidemia in South African HIV-infected patients." <i>PLoS One</i> (2016) http://hdl.handle.net/11427/18851en_ZA
dc.identifier.citationDave, J. A., Levitt, N. S., Ross, I. L., Lacerda, M., Maartens, G., & Blom, D. (2016). Anti-retroviral therapy increases the prevalence of dyslipidemia in South African HIV-infected patients. PloS one, 11(3), e0151911. doi:10.1371/journal.pone.0151911en_ZA
dc.identifier.ris TY - Journal Article AU - Dave, Joel A AU - Levitt, Naomi S AU - Ross, Ian L AU - Lacerda, Miguel AU - Maartens, Gary AU - Blom, Dirk AB - Purpose Data on the prevalence of dyslipidaemia and associated risk factors in HIV-infected patients from sub-Saharan Africa is sparse. We performed a cross-sectional analysis in a cohort of HIV-infected South African adults. METHODS: We studied HIV-infected patients who were either antiretroviral therapy (ART)-naive or receiving non-nucleoside reverse transcriptase inhibitor (NNRTI)-based or protease inhibitor (PI)-based ART. Evaluation included fasting lipograms, oral glucose tolerance tests and clinical anthropometry. Dyslipidemia was defined using the NCEP ATPIII guidelines. RESULTS: The median age of the participants was 34 years (range 19-68 years) and 78% were women. The prevalence of dyslipidemia in 406 ART-naive and 551 participants on ART was 90.0% and 85%, respectively. Low HDL-cholesterol (HDLC) was the most common abnormality [290/406 (71%) ART-naïve and 237/551 (43%) ART- participants]. Participants on ART had higher triglycerides (TG), total cholesterol (TC), LDL-cholesterol (LDLC) and HDLC than the ART-naïve group. Severe dyslipidaemia, (LDLC> 4.9 mmol/L or TG >5.0 mmol/L) was present in <5% of participants. In multivariate analyses there were complex associations between age, gender, type and duration of ART and body composition and LDLC, HDLC and TG, which differed between ART-naïve and ART-participants. CONCLUSION: Participants on ART had higher TG, TC, LDLC and HDLC than those who were ART-naïve but severe lipid abnormalities requiring evaluation and treatment were uncommon. DA - 2016 DB - OpenUCT DO - 10.1371/journal.pone.0151911 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Anti-retroviral therapy increases the prevalence of dyslipidemia in South African HIV-infected patients TI - Anti-retroviral therapy increases the prevalence of dyslipidemia in South African HIV-infected patients UR - http://hdl.handle.net/11427/18851 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0151911en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/18851
dc.identifier.vancouvercitationDave JA, Levitt NS, Ross IL, Lacerda M, Maartens G, Blom D. Anti-retroviral therapy increases the prevalence of dyslipidemia in South African HIV-infected patients. PLoS One. 2016; http://hdl.handle.net/11427/18851.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDivision of Endocrinology and Diabetologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2016 Dave et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherLipidsen_ZA
dc.subject.otherAntiretroviral therapyen_ZA
dc.subject.otherCholesterolen_ZA
dc.subject.otherLipoproteinsen_ZA
dc.subject.otherAnthropometryen_ZA
dc.subject.otherDyslipidemiaen_ZA
dc.subject.otherGlucose tolerance testsen_ZA
dc.subject.otherHIV infectionsen_ZA
dc.titleAnti-retroviral therapy increases the prevalence of dyslipidemia in South African HIV-infected patientsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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