IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections

dc.contributor.authorMarillier, Reeceen_ZA
dc.contributor.authorMichels, Chesneyen_ZA
dc.contributor.authorSmith, Elizabethen_ZA
dc.contributor.authorFick, Lizetteen_ZA
dc.contributor.authorLeeto, Mosiuoaen_ZA
dc.contributor.authorDewals, Benjaminen_ZA
dc.contributor.authorHorsnell, Williamen_ZA
dc.contributor.authorBrombacher, Franken_ZA
dc.date.accessioned2015-10-28T07:04:56Z
dc.date.available2015-10-28T07:04:56Z
dc.date.issued2008en_ZA
dc.description.abstractBACKGROUND: Intestinal mucus production by hyperplasic goblet cells is a striking pathological feature of many parasitic helminth infections and is related to intestinal protection and worm expulsion. Induction of goblet cell hyperplasia is associated with TH2 immune responses, which in helminth infections are controlled primarily by IL-13, and also IL-4. In the study presented here we examine the goblet cell hyperplasic response to three experimental parasitic helminth infections; namely Nippostrongylus brasiliensis, Syphacia obvelata and Schistosoma mansoni. RESULTS: As expected N. brasiliensis infection induced a strong goblet cell hyperplasia dependent on IL-4/IL-13/IL-4Ralpha expression. In contrast, and despite previously published transiently elevated IL-4/IL-13 levels, S. obvelata infections did not increase goblet cell hyperplasia in the colon. Furthermore, induction of goblet cell hyperplasia in response to S. mansoni eggs traversing the intestine was equivalent between BALB/c, IL-4/IL-13-/- and IL-4Ralpha-/- mice. CONCLUSION: Together these data demonstrate that intestinal goblet cell hyperplasia can be independent of TH2 immune responses associated with parasitic helminth infections.en_ZA
dc.identifier.apacitationMarillier, R., Michels, C., Smith, E., Fick, L., Leeto, M., Dewals, B., ... Brombacher, F. (2008). IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections. <i>BMC Immunology</i>, http://hdl.handle.net/11427/14469en_ZA
dc.identifier.chicagocitationMarillier, Reece, Chesney Michels, Elizabeth Smith, Lizette Fick, Mosiuoa Leeto, Benjamin Dewals, William Horsnell, and Frank Brombacher "IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections." <i>BMC Immunology</i> (2008) http://hdl.handle.net/11427/14469en_ZA
dc.identifier.citationMarillier, R. G., Michels, C., Smith, E. M., Fick, L. C., Leeto, M., Dewals, B., ... & Brombacher, F. (2008). IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections. BMC immunology, 9(1), 11.en_ZA
dc.identifier.ris TY - Journal Article AU - Marillier, Reece AU - Michels, Chesney AU - Smith, Elizabeth AU - Fick, Lizette AU - Leeto, Mosiuoa AU - Dewals, Benjamin AU - Horsnell, William AU - Brombacher, Frank AB - BACKGROUND: Intestinal mucus production by hyperplasic goblet cells is a striking pathological feature of many parasitic helminth infections and is related to intestinal protection and worm expulsion. Induction of goblet cell hyperplasia is associated with TH2 immune responses, which in helminth infections are controlled primarily by IL-13, and also IL-4. In the study presented here we examine the goblet cell hyperplasic response to three experimental parasitic helminth infections; namely Nippostrongylus brasiliensis, Syphacia obvelata and Schistosoma mansoni. RESULTS: As expected N. brasiliensis infection induced a strong goblet cell hyperplasia dependent on IL-4/IL-13/IL-4Ralpha expression. In contrast, and despite previously published transiently elevated IL-4/IL-13 levels, S. obvelata infections did not increase goblet cell hyperplasia in the colon. Furthermore, induction of goblet cell hyperplasia in response to S. mansoni eggs traversing the intestine was equivalent between BALB/c, IL-4/IL-13-/- and IL-4Ralpha-/- mice. CONCLUSION: Together these data demonstrate that intestinal goblet cell hyperplasia can be independent of TH2 immune responses associated with parasitic helminth infections. DA - 2008 DB - OpenUCT DO - 10.1186/1471-2172-9-11 DP - University of Cape Town J1 - BMC Immunology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections TI - IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections UR - http://hdl.handle.net/11427/14469 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14469
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2172-9-11
dc.identifier.vancouvercitationMarillier R, Michels C, Smith E, Fick L, Leeto M, Dewals B, et al. IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections. BMC Immunology. 2008; http://hdl.handle.net/11427/14469.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2008 Marillier et al; licensee BioMed Central Ltden_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/en_ZA
dc.sourceBMC Immunologyen_ZA
dc.source.urihttp://www.biomedcentral.com/bmcimmunol/en_ZA
dc.subject.otherAnimal immunologyen_ZA
dc.subject.otherAnimal parasitologyen_ZA
dc.subject.otherAnimal pathologyen_ZA
dc.titleIL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infectionsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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