Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula

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dc.contributor.advisorReddy, B Dayaen_ZA
dc.contributor.advisorMcBride, Andrew Trevoren_ZA
dc.contributor.authorGuess, Winstonen_ZA
dc.date.accessioned2017-01-20T07:48:17Z
dc.date.available2017-01-20T07:48:17Z
dc.date.issued2016en_ZA
dc.description.abstractThis research forms part of an interdisciplinary project that aims to improve the detailed understanding of the haemodynamics and vascular mechanics in arteriovenous shunts that are required for haemodialysis treatments. A combination of new PCMRA imaging and computational modelling of in vivo blood flow aims to determine the haemodynamic conditions that may lead to the high failure rate of vascular access in these circumstances. This thesis focuses on developing a patient-specific fluid-structure interaction (FSI) model of a PC-MRA imaged arteriovenous fistula. The numerical FSI model is developed and simulated within the commercial multiphysics simulation package ANSYS® Academic Research, Release 16. The blood flow is modelled as a Newtonian fluid with the finite-volume method solver ANSYS® Fluent®. A pulsatile mass-flow boundary condition is applied at the artery inlet and a three-element Windkessel model at the artery and vein outlets. ANSYS® Mechanical™, a finite element method solver, is used to model the nonlinear behaviour of the vessel walls. The artery and vein walls are assumed to follow a third-order Yeoh model, and are differentiated by thickness and by material strength characteristics. The staggered FSI model is configured and executed in ANSYS® Workbench™, forming a semi-implicit coupling of the blood flow and vessel wall models. This work shows the effectiveness of combining a number of stabilisation techniques to simultaneously overcome the added-mass effect and optimise the efficiency of the overall model. The PC-MRA data, fluid model, and FSI model show almost identical flow features in the fistula; this applies in particular to a flow recirculation region in the vein that could potentially lead to fistula failure.en_ZA
dc.identifier.apacitationGuess, W. (2016). <i>Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula</i>. (Thesis). University of Cape Town ,Faculty of Engineering & the Built Environment ,Centre for Research in Computational and Applied Mechanics (CERECAM). Retrieved from http://hdl.handle.net/11427/22840en_ZA
dc.identifier.chicagocitationGuess, Winston. <i>"Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula."</i> Thesis., University of Cape Town ,Faculty of Engineering & the Built Environment ,Centre for Research in Computational and Applied Mechanics (CERECAM), 2016. http://hdl.handle.net/11427/22840en_ZA
dc.identifier.citationGuess, W. 2016. Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Guess, Winston AB - This research forms part of an interdisciplinary project that aims to improve the detailed understanding of the haemodynamics and vascular mechanics in arteriovenous shunts that are required for haemodialysis treatments. A combination of new PCMRA imaging and computational modelling of in vivo blood flow aims to determine the haemodynamic conditions that may lead to the high failure rate of vascular access in these circumstances. This thesis focuses on developing a patient-specific fluid-structure interaction (FSI) model of a PC-MRA imaged arteriovenous fistula. The numerical FSI model is developed and simulated within the commercial multiphysics simulation package ANSYS® Academic Research, Release 16. The blood flow is modelled as a Newtonian fluid with the finite-volume method solver ANSYS® Fluent®. A pulsatile mass-flow boundary condition is applied at the artery inlet and a three-element Windkessel model at the artery and vein outlets. ANSYS® Mechanical™, a finite element method solver, is used to model the nonlinear behaviour of the vessel walls. The artery and vein walls are assumed to follow a third-order Yeoh model, and are differentiated by thickness and by material strength characteristics. The staggered FSI model is configured and executed in ANSYS® Workbench™, forming a semi-implicit coupling of the blood flow and vessel wall models. This work shows the effectiveness of combining a number of stabilisation techniques to simultaneously overcome the added-mass effect and optimise the efficiency of the overall model. The PC-MRA data, fluid model, and FSI model show almost identical flow features in the fistula; this applies in particular to a flow recirculation region in the vein that could potentially lead to fistula failure. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula TI - Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula UR - http://hdl.handle.net/11427/22840 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/22840
dc.identifier.vancouvercitationGuess W. Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula. [Thesis]. University of Cape Town ,Faculty of Engineering & the Built Environment ,Centre for Research in Computational and Applied Mechanics (CERECAM), 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/22840en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentCentre for Research in Computational and Applied Mechanics (CERECAM)en_ZA
dc.publisher.facultyFaculty of Engineering and the Built Environment
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMechanical Engineeringen_ZA
dc.titleFluid-structure interaction modelling of a patient-specific arteriovenous access fistulaen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Eng)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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