Tendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Review

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dc.contributor.authorRibbans, William J
dc.contributor.authorSeptember, Alison V
dc.contributor.authorCollins, Malcolm
dc.date.accessioned2022-07-21T11:46:23Z
dc.date.available2022-07-21T11:46:23Z
dc.date.issued2022-04-29
dc.date.updated2022-05-27T13:36:57Z
dc.description.abstractA significant proportion of patients requiring musculoskeletal management present with tendon and ligament pathology. Our understanding of the intrinsic and extrinsic mechanisms that lead to such disabilities is increasing. However, the complexity underpinning these interactive multifactorial elements is still not fully characterised. Evidence highlighting the genetic components, either reducing or increasing susceptibility to injury, is increasing. This review examines the present understanding of the role genetic variations contribute to tendon and ligament injury risk. It examines the different elements of tendon and ligament structure and considers our knowledge of genetic influence on form, function, ability to withstand load, and undertake repair or regeneration. The role of epigenetic factors in modifying gene expression in these structures is also explored. It considers the challenges to interpreting present knowledge, the requirements, and likely pathways for future research, and whether such information has reached the point of clinical utility.en_US
dc.identifierdoi: 10.3390/life12050663
dc.identifier.apacitationRibbans, W. J., September, A. V., & Collins, M. (2022). Tendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Review. <i>Life</i>, 12(5), 663. http://hdl.handle.net/11427/36655en_ZA
dc.identifier.chicagocitationRibbans, William J, Alison V September, and Malcolm Collins "Tendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Review." <i>Life</i> 12, 5. (2022): 663. http://hdl.handle.net/11427/36655en_ZA
dc.identifier.citationRibbans, W.J., September, A.V. & Collins, M. 2022. Tendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Review. <i>Life.</i> 12(5):663. http://hdl.handle.net/11427/36655en_ZA
dc.identifier.ris TY - Journal Article AU - Ribbans, William J AU - September, Alison V AU - Collins, Malcolm AB - A significant proportion of patients requiring musculoskeletal management present with tendon and ligament pathology. Our understanding of the intrinsic and extrinsic mechanisms that lead to such disabilities is increasing. However, the complexity underpinning these interactive multifactorial elements is still not fully characterised. Evidence highlighting the genetic components, either reducing or increasing susceptibility to injury, is increasing. This review examines the present understanding of the role genetic variations contribute to tendon and ligament injury risk. It examines the different elements of tendon and ligament structure and considers our knowledge of genetic influence on form, function, ability to withstand load, and undertake repair or regeneration. The role of epigenetic factors in modifying gene expression in these structures is also explored. It considers the challenges to interpreting present knowledge, the requirements, and likely pathways for future research, and whether such information has reached the point of clinical utility. DA - 2022-04-29 DB - OpenUCT DP - University of Cape Town IS - 5 J1 - Life LK - https://open.uct.ac.za PY - 2022 T1 - Tendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Review TI - Tendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Review UR - http://hdl.handle.net/11427/36655 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/36655
dc.identifier.vancouvercitationRibbans WJ, September AV, Collins M. Tendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Review. Life. 2022;12(5):663. http://hdl.handle.net/11427/36655.en_ZA
dc.language.isoenen_US
dc.publisher.departmentDivision of Physiological Sciencesen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceLifeen_US
dc.source.journalissue5en_US
dc.source.journalvolume12en_US
dc.source.pagination663en_US
dc.source.urihttps://www.mdpi.com/journal/life
dc.titleTendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Reviewen_US
dc.typeJournal Articleen_US
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