The role of melatonin in peripartum cardiomyopathy

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dc.contributor.advisorLecour, Sandrineen_ZA
dc.contributor.advisorSliwa, Karenen_ZA
dc.contributor.authorNicholson, Laurenen_ZA
dc.date.accessioned2014-07-29T09:08:55Z
dc.date.available2014-07-29T09:08:55Z
dc.date.issued2013en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references.
dc.description.abstractPeripartum cardiomyopathy (PPCM) is a heart disease of unknown aetiology emerging in previously healthy women towards the end of pregnancy or first postpartum months. Previous studies have suggested that oxidative stress contributes to the pathogenesis of PPCM. Melatonin is a powerful endogenous antioxidant that can limit the damaging effect of oxidative stress. Melatonin levels are known to be altered in sleep disruption, depression and other cardiac diseases. The aim of this study was to determine if melatonin levels are disrupted in women with PPCM compared to healthy patients. We hypothesised that sleep disruption and depression may contribute to a disruption in their melatonin levels.en_ZA
dc.identifier.apacitationNicholson, L. (2013). <i>The role of melatonin in peripartum cardiomyopathy</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3444en_ZA
dc.identifier.chicagocitationNicholson, Lauren. <i>"The role of melatonin in peripartum cardiomyopathy."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2013. http://hdl.handle.net/11427/3444en_ZA
dc.identifier.citationNicholson, L. 2013. The role of melatonin in peripartum cardiomyopathy. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Nicholson, Lauren AB - Peripartum cardiomyopathy (PPCM) is a heart disease of unknown aetiology emerging in previously healthy women towards the end of pregnancy or first postpartum months. Previous studies have suggested that oxidative stress contributes to the pathogenesis of PPCM. Melatonin is a powerful endogenous antioxidant that can limit the damaging effect of oxidative stress. Melatonin levels are known to be altered in sleep disruption, depression and other cardiac diseases. The aim of this study was to determine if melatonin levels are disrupted in women with PPCM compared to healthy patients. We hypothesised that sleep disruption and depression may contribute to a disruption in their melatonin levels. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - The role of melatonin in peripartum cardiomyopathy TI - The role of melatonin in peripartum cardiomyopathy UR - http://hdl.handle.net/11427/3444 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3444
dc.identifier.vancouvercitationNicholson L. The role of melatonin in peripartum cardiomyopathy. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3444en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleThe role of melatonin in peripartum cardiomyopathyen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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