A novel brief treatment for methamphetamine use disorders in South Africa: a randomised feasibility trial

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dc.contributor.authorSorsdahl, K
dc.contributor.authorStein, D J
dc.contributor.authorPasche, S
dc.contributor.authorJacobs, Y
dc.contributor.authorKader, R
dc.contributor.authorOdlaug, B
dc.contributor.authorRichter, S
dc.contributor.authorMyers, B
dc.contributor.authorGrant, J E
dc.date.accessioned2021-10-11T08:32:51Z
dc.date.available2021-10-11T08:32:51Z
dc.date.issued2021-01-07
dc.date.updated2021-01-10T04:12:51Z
dc.description.abstractBackground Effective brief treatments for methamphetamine use disorders (MAUD) are urgently needed to complement longer more intensive treatments in low and middle income countries, including South Africa. To address this gap, the purpose of this randomised feasibility trial was to determine the feasibility of delivering a six-session blended imaginal desensitisation, plus motivational interviewing (IDMI) intervention for adults with a MAUD. Methods We enrolled 60 adults with a MAUD and randomly assigned them 1:1 to the IDMI intervention delivered by clinical psychologists and a control group who we referred to usual care. Feasibility measures, such as rates of recruitment, consent to participate in the trial and retention, were calculated. Follow-up interviews were conducted at 6 weeks and 3 months post-enrollment. Results Over 9 months, 278 potential particiants initiated contact. Following initial screening 78 (28%) met inclusion criteria, and 60 (77%) were randomised. Thirteen of the 30 participants assigned to the treatment group completed the intervention. Both psychologists were highly adherent to the intervention, obtaining a fidelity rating of 91%. In total, 39 (65%) participants completed the 6-week follow-up and 40 (67%) completed the 3-month follow-up. The intervention shows potential effectiveness in the intention-to-treat analysis where frequency of methamphetamine use was significantly lower in the treatment than in the control group at both the 6 week and 3-month endpoints. No adverse outcomes were reported. Conclusions This feasibility trial suggests that the locally adapted IDMI intervention is an acceptable and safe intervention as a brief treatment for MAUD in South Africa. Modifications to the study design should be considered in a fully powered, definitive controlled trial to assess this potentially effective intervention. Trial registration The trial is registered with the Pan African Clinical Trials Registry (Trial ID: PACTR201310000589295)en_US
dc.identifier.apacitationSorsdahl, K., Stein, D. J., Pasche, S., Jacobs, Y., Kader, R., Odlaug, B., ... Grant, J. E. (2021). A novel brief treatment for methamphetamine use disorders in South Africa: a randomised feasibility trial. <i>Addiction Science & Clinical Practice</i>, 16(Article number: 3), http://hdl.handle.net/11427/35142en_ZA
dc.identifier.chicagocitationSorsdahl, K, D J Stein, S Pasche, Y Jacobs, R Kader, B Odlaug, S Richter, B Myers, and J E Grant "A novel brief treatment for methamphetamine use disorders in South Africa: a randomised feasibility trial." <i>Addiction Science & Clinical Practice</i> 16, Article number: 3. (2021) http://hdl.handle.net/11427/35142en_ZA
dc.identifier.citationSorsdahl, K., Stein, D.J., Pasche, S., Jacobs, Y., Kader, R., Odlaug, B., Richter, S. & Myers, B. et al. 2021. A novel brief treatment for methamphetamine use disorders in South Africa: a randomised feasibility trial. <i>Addiction Science & Clinical Practice.</i> 16(Article number: 3) http://hdl.handle.net/11427/35142en_ZA
dc.identifier.ris TY - Journal Article AU - Sorsdahl, K AU - Stein, D J AU - Pasche, S AU - Jacobs, Y AU - Kader, R AU - Odlaug, B AU - Richter, S AU - Myers, B AU - Grant, J E AB - Background Effective brief treatments for methamphetamine use disorders (MAUD) are urgently needed to complement longer more intensive treatments in low and middle income countries, including South Africa. To address this gap, the purpose of this randomised feasibility trial was to determine the feasibility of delivering a six-session blended imaginal desensitisation, plus motivational interviewing (IDMI) intervention for adults with a MAUD. Methods We enrolled 60 adults with a MAUD and randomly assigned them 1:1 to the IDMI intervention delivered by clinical psychologists and a control group who we referred to usual care. Feasibility measures, such as rates of recruitment, consent to participate in the trial and retention, were calculated. Follow-up interviews were conducted at 6 weeks and 3 months post-enrollment. Results Over 9 months, 278 potential particiants initiated contact. Following initial screening 78 (28%) met inclusion criteria, and 60 (77%) were randomised. Thirteen of the 30 participants assigned to the treatment group completed the intervention. Both psychologists were highly adherent to the intervention, obtaining a fidelity rating of 91%. In total, 39 (65%) participants completed the 6-week follow-up and 40 (67%) completed the 3-month follow-up. The intervention shows potential effectiveness in the intention-to-treat analysis where frequency of methamphetamine use was significantly lower in the treatment than in the control group at both the 6 week and 3-month endpoints. No adverse outcomes were reported. Conclusions This feasibility trial suggests that the locally adapted IDMI intervention is an acceptable and safe intervention as a brief treatment for MAUD in South Africa. Modifications to the study design should be considered in a fully powered, definitive controlled trial to assess this potentially effective intervention. Trial registration The trial is registered with the Pan African Clinical Trials Registry (Trial ID: PACTR201310000589295) DA - 2021-01-07 DB - OpenUCT DP - University of Cape Town IS - Article number: 3 J1 - Addiction Science & Clinical Practice KW - Feasibility trial KW - Substance use KW - Brief treatment KW - South Africa LK - https://open.uct.ac.za PY - 2021 T1 - A novel brief treatment for methamphetamine use disorders in South Africa: a randomised feasibility trial TI - A novel brief treatment for methamphetamine use disorders in South Africa: a randomised feasibility trial UR - http://hdl.handle.net/11427/35142 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s13722-020-00209-3
dc.identifier.urihttp://hdl.handle.net/11427/35142
dc.identifier.vancouvercitationSorsdahl K, Stein DJ, Pasche S, Jacobs Y, Kader R, Odlaug B, et al. A novel brief treatment for methamphetamine use disorders in South Africa: a randomised feasibility trial. Addiction Science & Clinical Practice. 2021;16(Article number: 3) http://hdl.handle.net/11427/35142.en_ZA
dc.language.isoenen_US
dc.language.rfc3066en
dc.publisher.departmentDepartment of Psychiatry and Mental Healthen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceAddiction Science & Clinical Practiceen_US
dc.source.journalissueArticle number: 3en_US
dc.source.journalvolume16en_US
dc.source.urihttps://ascpjournal.biomedcentral.com/
dc.subjectFeasibility trialen_US
dc.subjectSubstance useen_US
dc.subjectBrief treatmenten_US
dc.subjectSouth Africaen_US
dc.titleA novel brief treatment for methamphetamine use disorders in South Africa: a randomised feasibility trialen_US
dc.typeJournal Articleen_US
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