Synthesis and inclusion of S-aryl alkylthiosulfinates as stable allicin mimics

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dc.contributor.authorStellenboom, Nashia
dc.contributor.authorHunter, Roger
dc.contributor.authorCaira, Mino
dc.contributor.authorBourne, Susan
dc.contributor.authorCele, Khethiwe
dc.contributor.authorQwebani, Tozama
dc.date.accessioned2021-10-08T11:00:56Z
dc.date.available2021-10-08T11:00:56Z
dc.date.issued2007
dc.description.abstractS-Aryl alkylthiosulfinates showing aromatic rings with varying electronic demand have been prepared by oxidation of the corresponding disulfide, the latter prepared using new one-pot methodology involving thiol oxidation with 1-chlorobenzotriazole. Whereas thiosulfinates with electron-withdrawing substituents in the aromatic ring were unstable towards isolation, those with a releasing substituent in the para-position have shown good stability as potential allicin mimics and one of them (p-OMe) has been characterised as its inclusion compound in the cyclodextrin, TRIMEB, by X-ray crystallography.
dc.identifier.apacitationStellenboom, N., Hunter, R., Caira, M., Bourne, S., Cele, K., & Qwebani, T. (2007). Synthesis and inclusion of S-aryl alkylthiosulfinates as stable allicin mimics. <i>ARKIVOC - Online Journal of Organic Chemistry</i>, 9(4), 53 - 63. http://hdl.handle.net/11427/35051en_ZA
dc.identifier.chicagocitationStellenboom, Nashia, Roger Hunter, Mino Caira, Susan Bourne, Khethiwe Cele, and Tozama Qwebani "Synthesis and inclusion of S-aryl alkylthiosulfinates as stable allicin mimics." <i>ARKIVOC - Online Journal of Organic Chemistry</i> 9, 4. (2007): 53 - 63. http://hdl.handle.net/11427/35051en_ZA
dc.identifier.citationStellenboom, N., Hunter, R., Caira, M., Bourne, S., Cele, K. & Qwebani, T. 2007. Synthesis and inclusion of S-aryl alkylthiosulfinates as stable allicin mimics. <i>ARKIVOC - Online Journal of Organic Chemistry.</i> 9(4):53 - 63. http://hdl.handle.net/11427/35051en_ZA
dc.identifier.issn1424-6368
dc.identifier.issn1424-6376
dc.identifier.issn1551-7004
dc.identifier.issn1551-7012
dc.identifier.ris TY - Journal Article AU - Stellenboom, Nashia AU - Hunter, Roger AU - Caira, Mino AU - Bourne, Susan AU - Cele, Khethiwe AU - Qwebani, Tozama AB - S-Aryl alkylthiosulfinates showing aromatic rings with varying electronic demand have been prepared by oxidation of the corresponding disulfide, the latter prepared using new one-pot methodology involving thiol oxidation with 1-chlorobenzotriazole. Whereas thiosulfinates with electron-withdrawing substituents in the aromatic ring were unstable towards isolation, those with a releasing substituent in the para-position have shown good stability as potential allicin mimics and one of them (p-OMe) has been characterised as its inclusion compound in the cyclodextrin, TRIMEB, by X-ray crystallography. DA - 2007 DB - OpenUCT DP - University of Cape Town IS - 4 J1 - ARKIVOC - Online Journal of Organic Chemistry LK - https://open.uct.ac.za PY - 2007 SM - 1424-6368 SM - 1424-6376 SM - 1551-7004 SM - 1551-7012 T1 - Synthesis and inclusion of S-aryl alkylthiosulfinates as stable allicin mimics TI - Synthesis and inclusion of S-aryl alkylthiosulfinates as stable allicin mimics UR - http://hdl.handle.net/11427/35051 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/35051
dc.identifier.vancouvercitationStellenboom N, Hunter R, Caira M, Bourne S, Cele K, Qwebani T. Synthesis and inclusion of S-aryl alkylthiosulfinates as stable allicin mimics. ARKIVOC - Online Journal of Organic Chemistry. 2007;9(4):53 - 63. http://hdl.handle.net/11427/35051.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Chemistry
dc.publisher.facultyFaculty of Science
dc.sourceARKIVOC - Online Journal of Organic Chemistry
dc.source.journalissue4
dc.source.journalvolume9
dc.source.pagination53 - 63
dc.source.urihttps://dx.doi.org/10.7196/sajs.718
dc.subject.otherBurns
dc.subject.otherDisaster Planning
dc.subject.otherHumans
dc.subject.otherMass Casualty Incidents
dc.subject.otherNational Health Programs
dc.subject.otherPractice Guidelines as Topic
dc.subject.otherSocieties, Medical
dc.subject.otherSouth Africa
dc.titleSynthesis and inclusion of S-aryl alkylthiosulfinates as stable allicin mimics
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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