Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis

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dc.contributor.authorHemady, Chad L
dc.contributor.authorSpeyer, Lydia G
dc.contributor.authorMurray, Aja L
dc.contributor.authorBrown, Ruth H
dc.contributor.authorMeinck, Franziska
dc.contributor.authorFry, Deborah
dc.contributor.authorDo, Huyen
dc.contributor.authorSikander, Siham
dc.contributor.authorMadrid, Bernadette
dc.contributor.authorFernando, Asvini
dc.contributor.authorWalker, Susan
dc.contributor.authorDunne, Michael
dc.contributor.authorFoley, Sarah
dc.contributor.authorHughes, Claire
dc.contributor.authorOsafo, Joseph
dc.contributor.authorBaban, Adriana
dc.contributor.authorTaut, Diana
dc.contributor.authorWard, Catherine L
dc.contributor.authorVan Thang, Vo
dc.contributor.authorFearon, Pasco
dc.contributor.authorTomlinson, Mark
dc.contributor.authorValdebenito, Sara
dc.contributor.authorEisner, Manuel
dc.date.accessioned2022-09-15T13:28:56Z
dc.date.available2022-09-15T13:28:56Z
dc.date.issued2022-06-22
dc.date.updated2022-06-26T03:12:59Z
dc.description.abstractBackground This paper enumerates and characterizes latent classes of adverse childhood experiences and investigates how they relate to prenatal substance use (i.e., smoking, alcohol, and other drugs) and poor infant outcomes (i.e., infant prematurity and low birthweight) across eight low- and middle-income countries (LMICs). Methods A total of 1189 mother-infant dyads from the Evidence for Better Lives Study cohort were recruited. Latent class analysis using the Bolck, Croon, and Hagenaars (BCH) 3-step method with auxiliary multilevel logistic regressions was performed. Results Three high-risk classes and one low-risk class emerged: (1) highly maltreated (7%, n = 89), (2) emotionally and physically abused with intra-familial violence exposure (13%, n = 152), (3), emotionally abused (40%, n = 474), and (4) low household dysfunction and abuse (40%, n = 474). Pairwise comparisons between classes indicate higher probabilities of prenatal drug use in the highly maltreated and emotionally abused classes compared with the low household dysfunction and abuse class. Additionally, the emotionally and physically abused with intra-familial violence exposure class had higher probability of low birthweight than the three remaining classes. Conclusion Our results highlight the multifaceted nature of ACEs and underline the potential importance of exposure to childhood adversities on behaviors and outcomes in the perinatal period. This can inform the design of antenatal support to better address these challenges.en_US
dc.identifier.apacitationHemady, C. L., Speyer, L. G., Murray, A. L., Brown, R. H., Meinck, F., Fry, D., ... Eisner, M. (2022). Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis. <i>BMC Pregnancy and Childbirth</i>, 22(1), 505. http://hdl.handle.net/11427/36816en_ZA
dc.identifier.chicagocitationHemady, Chad L, Lydia G Speyer, Aja L Murray, Ruth H Brown, Franziska Meinck, Deborah Fry, Huyen Do, et al "Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis." <i>BMC Pregnancy and Childbirth</i> 22, 1. (2022): 505. http://hdl.handle.net/11427/36816en_ZA
dc.identifier.citationHemady, C.L., Speyer, L.G., Murray, A.L., Brown, R.H., Meinck, F., Fry, D., Do, H. & Sikander, S. et al. 2022. Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis. <i>BMC Pregnancy and Childbirth.</i> 22(1):505. http://hdl.handle.net/11427/36816en_ZA
dc.identifier.ris TY - Journal Article AU - Hemady, Chad L AU - Speyer, Lydia G AU - Murray, Aja L AU - Brown, Ruth H AU - Meinck, Franziska AU - Fry, Deborah AU - Do, Huyen AU - Sikander, Siham AU - Madrid, Bernadette AU - Fernando, Asvini AU - Walker, Susan AU - Dunne, Michael AU - Foley, Sarah AU - Hughes, Claire AU - Osafo, Joseph AU - Baban, Adriana AU - Taut, Diana AU - Ward, Catherine L AU - Van Thang, Vo AU - Fearon, Pasco AU - Tomlinson, Mark AU - Valdebenito, Sara AU - Eisner, Manuel AB - Background This paper enumerates and characterizes latent classes of adverse childhood experiences and investigates how they relate to prenatal substance use (i.e., smoking, alcohol, and other drugs) and poor infant outcomes (i.e., infant prematurity and low birthweight) across eight low- and middle-income countries (LMICs). Methods A total of 1189 mother-infant dyads from the Evidence for Better Lives Study cohort were recruited. Latent class analysis using the Bolck, Croon, and Hagenaars (BCH) 3-step method with auxiliary multilevel logistic regressions was performed. Results Three high-risk classes and one low-risk class emerged: (1) highly maltreated (7%, n = 89), (2) emotionally and physically abused with intra-familial violence exposure (13%, n = 152), (3), emotionally abused (40%, n = 474), and (4) low household dysfunction and abuse (40%, n = 474). Pairwise comparisons between classes indicate higher probabilities of prenatal drug use in the highly maltreated and emotionally abused classes compared with the low household dysfunction and abuse class. Additionally, the emotionally and physically abused with intra-familial violence exposure class had higher probability of low birthweight than the three remaining classes. Conclusion Our results highlight the multifaceted nature of ACEs and underline the potential importance of exposure to childhood adversities on behaviors and outcomes in the perinatal period. This can inform the design of antenatal support to better address these challenges. DA - 2022-06-22 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - BMC Pregnancy and Childbirth KW - Adverse childhood experiences KW - Latent class analysis KW - Maternal health KW - Neonatal health KW - Prenatal substance use KW - Intergenerational transmission of adversity LK - https://open.uct.ac.za PY - 2022 T1 - Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis TI - Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis UR - http://hdl.handle.net/11427/36816 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s12884-022-04839-0
dc.identifier.urihttp://hdl.handle.net/11427/36816
dc.identifier.vancouvercitationHemady CL, Speyer LG, Murray AL, Brown RH, Meinck F, Fry D, et al. Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis. BMC Pregnancy and Childbirth. 2022;22(1):505. http://hdl.handle.net/11427/36816.en_ZA
dc.language.isoenen_US
dc.language.rfc3066en
dc.publisher.departmentDepartment of Psychologyen_US
dc.publisher.facultyFaculty of Humanitiesen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceBMC Pregnancy and Childbirthen_US
dc.source.journalissue1en_US
dc.source.journalvolume22en_US
dc.source.pagination505en_US
dc.source.urihttps://bmcpregnancychildbirth.biomedcentral.com/
dc.subjectAdverse childhood experiencesen_US
dc.subjectLatent class analysisen_US
dc.subjectMaternal healthen_US
dc.subjectNeonatal healthen_US
dc.subjectPrenatal substance useen_US
dc.subjectIntergenerational transmission of adversityen_US
dc.titlePatterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysisen_US
dc.typeJournal Articleen_US
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