Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients

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dc.contributor.authorPepper, Dominique Jen_ZA
dc.contributor.authorMarais, Suzaanen_ZA
dc.contributor.authorBhaijee, Feriylen_ZA
dc.contributor.authorWilkinson, Robert Jen_ZA
dc.contributor.authorDe Azevedo, Virginiaen_ZA
dc.contributor.authorMeintjes, Graemeen_ZA
dc.date.accessioned2016-01-11T06:56:15Z
dc.date.available2016-01-11T06:56:15Z
dc.date.issued2012en_ZA
dc.description.abstractSetting: A South African township clinic where loss to follow-up during TB treatment may prevent HIV-infected TB patients from receiving life-saving ART. Objective: To determine factors associated with loss to follow-up during TB treatment. Design: Regression analyses of a cohort of ART-eligible TB patients who commenced TB treatment and were followed for 24 weeks. RESULTS: Of 111 ART-eligible TB patients, 15 (14%) died in the ensuing 24 weeks. Of the remaining 96 TB patients, 11 (11%) were lost to follow-up. All TB patients lost to follow-up did not initiate ART. Of 85 TB patients in follow-up, 62 (73%) initiated ART 56 days after TB diagnosis (median, IQR 33-77 days) and 31 days after initial assessment at an ART clinic (median, IQR: 18-55 days). The median duration from TB diagnosis to initial assessment at an ART clinic was 19 days (IQR: 7-48 days). At 24 weeks, 6 of 85 (7%) TB patients who presented to an ART clinic for assessment were lost to follow-up, compared to 5 of 11 (45%) TB patients who did not present to an ART clinic for assessment. Logistic regression analysis (adjusted odds ratio  = 0.1, 95% confidence interval [95% CI]: 0.03-0.66) and our Cox proportional hazards model (hazard ratio  = 0.2, 95% CI: 0.04-0.68) confirmed that assessment at an ART clinic during TB treatment reduced loss to follow-up. CONCLUSION: Assessment at antiretroviral clinics for HIV care by trained health-care providers reduces loss to follow-up among HIV-infected patients with TB.en_ZA
dc.identifier.apacitationPepper, D. J., Marais, S., Bhaijee, F., Wilkinson, R. J., De Azevedo, V., & Meintjes, G. (2012). Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients. <i>PLoS One</i>, http://hdl.handle.net/11427/16312en_ZA
dc.identifier.chicagocitationPepper, Dominique J, Suzaan Marais, Feriyl Bhaijee, Robert J Wilkinson, Virginia De Azevedo, and Graeme Meintjes "Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients." <i>PLoS One</i> (2012) http://hdl.handle.net/11427/16312en_ZA
dc.identifier.citationPepper, D. J., Marais, S., Bhaijee, F., Wilkinson, R. J., De Azevedo, V., & Meintjes, G. (2012). Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients. PloS one, 7(6), e37634. doi:10.1371/journal.pone.0037634en_ZA
dc.identifier.ris TY - Journal Article AU - Pepper, Dominique J AU - Marais, Suzaan AU - Bhaijee, Feriyl AU - Wilkinson, Robert J AU - De Azevedo, Virginia AU - Meintjes, Graeme AB - Setting: A South African township clinic where loss to follow-up during TB treatment may prevent HIV-infected TB patients from receiving life-saving ART. Objective: To determine factors associated with loss to follow-up during TB treatment. Design: Regression analyses of a cohort of ART-eligible TB patients who commenced TB treatment and were followed for 24 weeks. RESULTS: Of 111 ART-eligible TB patients, 15 (14%) died in the ensuing 24 weeks. Of the remaining 96 TB patients, 11 (11%) were lost to follow-up. All TB patients lost to follow-up did not initiate ART. Of 85 TB patients in follow-up, 62 (73%) initiated ART 56 days after TB diagnosis (median, IQR 33-77 days) and 31 days after initial assessment at an ART clinic (median, IQR: 18-55 days). The median duration from TB diagnosis to initial assessment at an ART clinic was 19 days (IQR: 7-48 days). At 24 weeks, 6 of 85 (7%) TB patients who presented to an ART clinic for assessment were lost to follow-up, compared to 5 of 11 (45%) TB patients who did not present to an ART clinic for assessment. Logistic regression analysis (adjusted odds ratio  = 0.1, 95% confidence interval [95% CI]: 0.03-0.66) and our Cox proportional hazards model (hazard ratio  = 0.2, 95% CI: 0.04-0.68) confirmed that assessment at an ART clinic during TB treatment reduced loss to follow-up. CONCLUSION: Assessment at antiretroviral clinics for HIV care by trained health-care providers reduces loss to follow-up among HIV-infected patients with TB. DA - 2012 DB - OpenUCT DO - 10.1371/journal.pone.0037634 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients TI - Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients UR - http://hdl.handle.net/11427/16312 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16312
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0037634
dc.identifier.vancouvercitationPepper DJ, Marais S, Bhaijee F, Wilkinson RJ, De Azevedo V, Meintjes G. Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients. PLoS One. 2012; http://hdl.handle.net/11427/16312.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightscredited.en_ZA
dc.rights.holder© 2012 Pepper et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherTuberculosisen_ZA
dc.subject.otherAntiretroviral therapyen_ZA
dc.subject.otherTuberculosis diagnosis and managementen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherAdultsen_ZA
dc.subject.otherAntiretroviralsen_ZA
dc.subject.otherHistory of tuberculosisen_ZA
dc.subject.otherDrug screeningen_ZA
dc.titleAssessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patientsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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