Osseointegration potential for heat treated 3D Ti6Al4V scaffolds seeded with mysenchymal stem cells in vitro

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dc.contributor.advisorVicatos, Georgeen_ZA
dc.contributor.advisorKidson, Susanen_ZA
dc.contributor.authorVan Heerden, Estheren_ZA
dc.date.accessioned2014-08-05T12:30:26Z
dc.date.available2014-08-05T12:30:26Z
dc.date.issued2014en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references.
dc.description.abstractAseptic loosening of artificial joints occurs due to the loss of implant fixation. By implementing a 3D porous structure at the bone-implant interface, the ingrowth of bone will permit better and stronger interlocking of the implant to prevent loosening. In this study, it is hypothesized that the seeding of 3D scaffolding structures with mesenchymal stem cells (MSCs) will improve the potential for osseointegration of the implants, as the existing bone may be more inclined to unite with developing bone than with the implant substrate. Titanium-6 Aluminium-4 Vanadium (Ti64) is one of the most commonly used implant materials. Heat treatment of Ti64 was seen in tests done at the University of Cape Town to further improve against implant failure by vastly improving the materials strength and reducing debris formation. Thus the aim of this study was to investigate the effects the heat treatment of Ti64 would have on the capabilities of seeded MSCs in vitro.en_ZA
dc.identifier.apacitationVan Heerden, E. (2014). <i>Osseointegration potential for heat treated 3D Ti6Al4V scaffolds seeded with mysenchymal stem cells in vitro</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/6012en_ZA
dc.identifier.chicagocitationVan Heerden, Esther. <i>"Osseointegration potential for heat treated 3D Ti6Al4V scaffolds seeded with mysenchymal stem cells in vitro."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2014. http://hdl.handle.net/11427/6012en_ZA
dc.identifier.citationVan Heerden, E. 2014. Osseointegration potential for heat treated 3D Ti6Al4V scaffolds seeded with mysenchymal stem cells in vitro. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Van Heerden, Esther AB - Aseptic loosening of artificial joints occurs due to the loss of implant fixation. By implementing a 3D porous structure at the bone-implant interface, the ingrowth of bone will permit better and stronger interlocking of the implant to prevent loosening. In this study, it is hypothesized that the seeding of 3D scaffolding structures with mesenchymal stem cells (MSCs) will improve the potential for osseointegration of the implants, as the existing bone may be more inclined to unite with developing bone than with the implant substrate. Titanium-6 Aluminium-4 Vanadium (Ti64) is one of the most commonly used implant materials. Heat treatment of Ti64 was seen in tests done at the University of Cape Town to further improve against implant failure by vastly improving the materials strength and reducing debris formation. Thus the aim of this study was to investigate the effects the heat treatment of Ti64 would have on the capabilities of seeded MSCs in vitro. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Osseointegration potential for heat treated 3D Ti6Al4V scaffolds seeded with mysenchymal stem cells in vitro TI - Osseointegration potential for heat treated 3D Ti6Al4V scaffolds seeded with mysenchymal stem cells in vitro UR - http://hdl.handle.net/11427/6012 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6012
dc.identifier.vancouvercitationVan Heerden E. Osseointegration potential for heat treated 3D Ti6Al4V scaffolds seeded with mysenchymal stem cells in vitro. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6012en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleOsseointegration potential for heat treated 3D Ti6Al4V scaffolds seeded with mysenchymal stem cells in vitroen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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