Investigating the effects of impermeant anions on the electrical and computational properties on neurons
| dc.contributor.advisor | Raimondo, Joseph | |
| dc.contributor.author | Shorer, Eran | |
| dc.date.accessioned | 2023-07-28T06:59:52Z | |
| dc.date.available | 2023-07-28T06:59:52Z | |
| dc.date.issued | 2023 | |
| dc.date.updated | 2023-07-28T06:59:20Z | |
| dc.description.abstract | Impermeant anions (proteins, amino acids, etc.) are negatively charged ions that are unable to traverse the cell membrane. Impermeant anion quantities and their average charge vary with metabolism as well as protein and nucleic acid synthesis/turnover.The effect of spatiotemporal changes to impermeant anions on neurons is poorly understood. Using a multicompartment electrodiffusion-based computational model I investigated the influence of impermeant anions on neuronal cellular physiology, passive cable properties, and synaptic integration. Spatial differences in the average charge of impermeant anions result in a nonisopotential dendrite with ionic microdomains. At steady state local discrepancies in membrane potentials and ion concentrations do not impact the passive or active electrical properties of neurons as ionic driving forces are unchanged, irrespective of impermeant anion mean charge. These findings explain how electrical signalling remains consistent in the face of an ever-changing impermeant anion milieu with implications related to our understanding of both normal and pathological neuronal physiology. | |
| dc.identifier.apacitation | Shorer, E. (2023). <i>Investigating the effects of impermeant anions on the electrical and computational properties on neurons</i>. (). ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/38163 | en_ZA |
| dc.identifier.chicagocitation | Shorer, Eran. <i>"Investigating the effects of impermeant anions on the electrical and computational properties on neurons."</i> ., ,Faculty of Health Sciences ,Department of Human Biology, 2023. http://hdl.handle.net/11427/38163 | en_ZA |
| dc.identifier.citation | Shorer, E. 2023. Investigating the effects of impermeant anions on the electrical and computational properties on neurons. . ,Faculty of Health Sciences ,Department of Human Biology. http://hdl.handle.net/11427/38163 | en_ZA |
| dc.identifier.ris | TY - Master Thesis AU - Shorer, Eran AB - Impermeant anions (proteins, amino acids, etc.) are negatively charged ions that are unable to traverse the cell membrane. Impermeant anion quantities and their average charge vary with metabolism as well as protein and nucleic acid synthesis/turnover.The effect of spatiotemporal changes to impermeant anions on neurons is poorly understood. Using a multicompartment electrodiffusion-based computational model I investigated the influence of impermeant anions on neuronal cellular physiology, passive cable properties, and synaptic integration. Spatial differences in the average charge of impermeant anions result in a nonisopotential dendrite with ionic microdomains. At steady state local discrepancies in membrane potentials and ion concentrations do not impact the passive or active electrical properties of neurons as ionic driving forces are unchanged, irrespective of impermeant anion mean charge. These findings explain how electrical signalling remains consistent in the face of an ever-changing impermeant anion milieu with implications related to our understanding of both normal and pathological neuronal physiology. DA - 2023_ DB - OpenUCT DP - University of Cape Town KW - Medicine LK - https://open.uct.ac.za PY - 2023 T1 - Investigating the effects of impermeant anions on the electrical and computational properties on neurons TI - Investigating the effects of impermeant anions on the electrical and computational properties on neurons UR - http://hdl.handle.net/11427/38163 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/38163 | |
| dc.identifier.vancouvercitation | Shorer E. Investigating the effects of impermeant anions on the electrical and computational properties on neurons. []. ,Faculty of Health Sciences ,Department of Human Biology, 2023 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/38163 | en_ZA |
| dc.language.rfc3066 | eng | |
| dc.publisher.department | Department of Human Biology | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.subject | Medicine | |
| dc.title | Investigating the effects of impermeant anions on the electrical and computational properties on neurons | |
| dc.type | Master Thesis | |
| dc.type.qualificationlevel | Masters | |
| dc.type.qualificationlevel | MSc |