The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease

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dc.contributor.advisorAllin, Rosemary
dc.contributor.advisorFolb, Peter I
dc.contributor.authorZent, Clive Steven
dc.contributor.authorZent, Clive Steven
dc.date.accessioned2017-08-24T07:27:07Z
dc.date.available2017-08-24T07:27:07Z
dc.date.issued1991
dc.date.updated2017-07-10T12:44:34Z
dc.description.abstractThe use of aminoglycosides in the treatment of the febrile neutropaenic patient with haematological disease is difficult and often suboptimal. This study reviews the available literature to establish therapeutic guidelines in this population and then reports the use of a Bayesian statistics based predictive model to implement and manage therapy in 10 patients. A review of the literature on aminoglycoside Pharmacology and clinical use is essential to determine therapeutic guidelines for this population. Aminoglycosides are amino sugars in glycosidic linkage and are polycations at physiological PH. The antibiotic effect is mediated through inhibition of protein synthesis and disruption of cell membrane integrity. Principal use is in treatment of Gram negative infection although aminoglycosides have activity against some Gram positive organisms including staphylococci. Aminoglycosides are inactive against anaerobes. Acquired resistance is mediated by bacterial enzymatic drug metabolism. Aminoglycosides are nephro- and ototoxic, this is the major constraint in clinical use.
dc.identifier.apacitationZent, C. S., & Zent, C. S. (1991). <i>The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/24969en_ZA
dc.identifier.chicagocitationZent, Clive Steven, and Clive Steven Zent. <i>"The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 1991. http://hdl.handle.net/11427/24969en_ZA
dc.identifier.citationZent, C., Zent, C. 1991. The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Zent, Clive Steven AU - Zent, Clive Steven AB - The use of aminoglycosides in the treatment of the febrile neutropaenic patient with haematological disease is difficult and often suboptimal. This study reviews the available literature to establish therapeutic guidelines in this population and then reports the use of a Bayesian statistics based predictive model to implement and manage therapy in 10 patients. A review of the literature on aminoglycoside Pharmacology and clinical use is essential to determine therapeutic guidelines for this population. Aminoglycosides are amino sugars in glycosidic linkage and are polycations at physiological PH. The antibiotic effect is mediated through inhibition of protein synthesis and disruption of cell membrane integrity. Principal use is in treatment of Gram negative infection although aminoglycosides have activity against some Gram positive organisms including staphylococci. Aminoglycosides are inactive against anaerobes. Acquired resistance is mediated by bacterial enzymatic drug metabolism. Aminoglycosides are nephro- and ototoxic, this is the major constraint in clinical use. DA - 1991 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1991 T1 - The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease TI - The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease UR - http://hdl.handle.net/11427/24969 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/24969
dc.identifier.vancouvercitationZent CS, Zent CS. The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 1991 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/24969en_ZA
dc.language.isoeng
dc.language.isoeng
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherAntibiotics, Aminoglycoside - pharmacology
dc.subject.otherAntibiotics, Aminoglycoside - therapeutic use
dc.subject.otherHematologic Diseases - drug therapy
dc.subject.otherNeutropenia - drug therapy
dc.subject.otherAntibiotics, Aminoglycoside - pharmacology~Antibiotics, Aminoglycoside - therapeutic use~Hematologic Diseases - drug therapy~Neutropenia - drug therapy
dc.titleThe use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease
dc.titleThe use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMed
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearch
uct.type.resourceThesis
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