The BDNF p.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse

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dc.contributor.authorDalvie, Shareefa
dc.contributor.authorStein, Dan J
dc.contributor.authorKoenen, Karestan
dc.contributor.authorCardenas, Valerie
dc.contributor.authorCuzen, Natalie L
dc.contributor.authorRamesar, Raj
dc.contributor.authorFein, George
dc.contributor.authorBrooks, Samantha J
dc.date.accessioned2015-01-21T13:17:15Z
dc.date.available2015-01-21T13:17:15Z
dc.date.issued2014-12-16
dc.date.updated2015-01-15T17:52:54Z
dc.description.abstractBackground: Previous studies have indicated that early life adversity, genetic factors and alcohol dependence are associated with reduced brain volume in adolescents. However, data on the interactive effects of early life adversity, genetic factors (e.g. p.Met66 allele of BDNF), and alcohol dependence, on brain structure in adolescents is limited. We examined whether the BDNF p.Val66Met polymorphism interacts with childhood trauma to predict alterations in brain volume in adolescents with alcohol use disorders (AUDs). Methods: We examined 160 participants (80 adolescents with DSM-IV AUD and 80 age- and gender-matched controls) who were assessed for trauma using the Childhood Trauma Questionnaire (CTQ). Magnetic resonance images were acquired for a subset of the cohort (58 AUD and 58 controls) and volumes of global and regional structures were estimated using voxel-based morphometry (VBM). Samples were genotyped for the p.Val66Met polymorphism using the TaqMan® Assay. Analysis of covariance (ANCOVA) and post-hoc t-tests were conducted using SPM8 VBM. Results: No significant associations, corrected for multiple comparisons, were found between the BDNF p.Val66Met polymorphism, brain volumes and AUD in adolescents with childhood trauma. Conclusions: These preliminary findings suggest that the BDNF p.Met66 allele and childhood trauma may not be associated with reduced structural volumes in AUD. Other genetic contributors should be investigated in future studies.en_ZA
dc.identifier.apacitationDalvie, S., Stein, D. J., Koenen, K., Cardenas, V., Cuzen, N. L., Ramesar, R., ... Brooks, S. J. (2014). The BDNF p.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse. <i>BMC Psychiatry</i>, http://hdl.handle.net/11427/12287en_ZA
dc.identifier.chicagocitationDalvie, Shareefa, Dan J Stein, Karestan Koenen, Valerie Cardenas, Natalie L Cuzen, Raj Ramesar, George Fein, and Samantha J Brooks "The BDNF p.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse." <i>BMC Psychiatry</i> (2014) http://hdl.handle.net/11427/12287en_ZA
dc.identifier.citationBMC Psychiatry. 2014 Dec 16;14(1):328en_ZA
dc.identifier.issn1471-244Xen_ZA
dc.identifier.ris TY - Journal Article AU - Dalvie, Shareefa AU - Stein, Dan J AU - Koenen, Karestan AU - Cardenas, Valerie AU - Cuzen, Natalie L AU - Ramesar, Raj AU - Fein, George AU - Brooks, Samantha J AB - Background: Previous studies have indicated that early life adversity, genetic factors and alcohol dependence are associated with reduced brain volume in adolescents. However, data on the interactive effects of early life adversity, genetic factors (e.g. p.Met66 allele of BDNF), and alcohol dependence, on brain structure in adolescents is limited. We examined whether the BDNF p.Val66Met polymorphism interacts with childhood trauma to predict alterations in brain volume in adolescents with alcohol use disorders (AUDs). Methods: We examined 160 participants (80 adolescents with DSM-IV AUD and 80 age- and gender-matched controls) who were assessed for trauma using the Childhood Trauma Questionnaire (CTQ). Magnetic resonance images were acquired for a subset of the cohort (58 AUD and 58 controls) and volumes of global and regional structures were estimated using voxel-based morphometry (VBM). Samples were genotyped for the p.Val66Met polymorphism using the TaqMan® Assay. Analysis of covariance (ANCOVA) and post-hoc t-tests were conducted using SPM8 VBM. Results: No significant associations, corrected for multiple comparisons, were found between the BDNF p.Val66Met polymorphism, brain volumes and AUD in adolescents with childhood trauma. Conclusions: These preliminary findings suggest that the BDNF p.Met66 allele and childhood trauma may not be associated with reduced structural volumes in AUD. Other genetic contributors should be investigated in future studies. DA - 2014-12-16 DB - OpenUCT DO - 10.1186/s12888-014-0328-2 DP - University of Cape Town J1 - BMC Psychiatry LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 SM - 1471-244X T1 - The BDNF p.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse TI - The BDNF p.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse UR - http://hdl.handle.net/11427/12287 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1186/s12888-014-0328-2
dc.identifier.urihttp://hdl.handle.net/11427/12287
dc.identifier.urihttp://hdl.handle.net/11427/12287
dc.identifier.urihttp://dx.doi.org/10.1186/s12888-014-0328-2
dc.identifier.vancouvercitationDalvie S, Stein DJ, Koenen K, Cardenas V, Cuzen NL, Ramesar R, et al. The BDNF p.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse. BMC Psychiatry. 2014; http://hdl.handle.net/11427/12287.en_ZA
dc.languageengen_ZA
dc.language.rfc3066en
dc.publisherBioMed Centralen_ZA
dc.publisher.departmentMRC/UCT Human Genetics Research Uniten_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rights.holderDalvie et al.; licensee BioMed Central.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_ZA
dc.sourceBMC Psychiatryen_ZA
dc.source.urihttp://www.biomedcentral.com/1471-244X/
dc.subject.otherChildhood trauma questionnaireen_ZA
dc.subject.otherAlcohol use disordersen_ZA
dc.subject.otherMagnetic resonance imagingen_ZA
dc.subject.otherVoxel-based morphometryen_ZA
dc.titleThe BDNF p.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuseen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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