Antiretroviral therapy outcomes among adolescents and youth in rural Zimbabwe

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dc.contributor.authorBygrave, Helenen_ZA
dc.contributor.authorMtangirwa, Judithen_ZA
dc.contributor.authorNcube, Kwenzakwenkosien_ZA
dc.contributor.authorFord, Nathanen_ZA
dc.contributor.authorKranzer, Katharinaen_ZA
dc.contributor.authorMunyaradzi, Dhodhoen_ZA
dc.date.accessioned2015-11-16T04:09:35Z
dc.date.available2015-11-16T04:09:35Z
dc.date.issued2012en_ZA
dc.description.abstractAround 2 million adolescents and 3 million youth are estimated to be living with HIV worldwide. Antiretroviral outcomes for this group appear to be worse compared to adults. We report antiretroviral therapy outcomes from a rural setting in Zimbabwe among patients aged 10-30 years who were initiated on ART between 2005 and 2008. The cohort was stratified into four age groups: 10-15 (young adolescents) 15.1-19 years (adolescents), 19.1-24 years (young adults) and 24.1-29.9 years (older adults). Survival analysis was used to estimate rates of deaths and loss to follow-up stratified by age group. Endpoints were time from ART initiation to death or loss to follow-up. Follow-up of patients on continuous therapy was censored at date of transfer, or study end (31 December 2008). Sex-adjusted Cox proportional hazards models were used to estimate hazard ratios for different age groups. 898 patients were included in the analysis; median duration on ART was 468 days. The risk of death were highest in adults compared to young adolescents (aHR 2.25, 95%CI 1.17-4.35). Young adults and adolescents had a 2-3 times higher risk of loss to follow-up compared to young adolescents. When estimating the risk of attrition combining loss to follow-up and death, young adults had the highest risk (aHR 2.70, 95%CI 1.62-4.52). This study highlights the need for adapted adherence support and service delivery models for both adolescents and young adults.en_ZA
dc.identifier.apacitationBygrave, H., Mtangirwa, J., Ncube, K., Ford, N., Kranzer, K., & Munyaradzi, D. (2012). Antiretroviral therapy outcomes among adolescents and youth in rural Zimbabwe. <i>PLoS One</i>, http://hdl.handle.net/11427/14995en_ZA
dc.identifier.chicagocitationBygrave, Helen, Judith Mtangirwa, Kwenzakwenkosi Ncube, Nathan Ford, Katharina Kranzer, and Dhodho Munyaradzi "Antiretroviral therapy outcomes among adolescents and youth in rural Zimbabwe." <i>PLoS One</i> (2012) http://hdl.handle.net/11427/14995en_ZA
dc.identifier.citationBygrave, H., Mtangirwa, J., Ncube, K., Ford, N., Kranzer, K., & Munyaradzi, D. (2011). Antiretroviral therapy outcomes among adolescents and youth in rural Zimbabwe. PloS one, 7(12), e52856. doi:10.1371/journal.pone.0052856en_ZA
dc.identifier.ris TY - Journal Article AU - Bygrave, Helen AU - Mtangirwa, Judith AU - Ncube, Kwenzakwenkosi AU - Ford, Nathan AU - Kranzer, Katharina AU - Munyaradzi, Dhodho AB - Around 2 million adolescents and 3 million youth are estimated to be living with HIV worldwide. Antiretroviral outcomes for this group appear to be worse compared to adults. We report antiretroviral therapy outcomes from a rural setting in Zimbabwe among patients aged 10-30 years who were initiated on ART between 2005 and 2008. The cohort was stratified into four age groups: 10-15 (young adolescents) 15.1-19 years (adolescents), 19.1-24 years (young adults) and 24.1-29.9 years (older adults). Survival analysis was used to estimate rates of deaths and loss to follow-up stratified by age group. Endpoints were time from ART initiation to death or loss to follow-up. Follow-up of patients on continuous therapy was censored at date of transfer, or study end (31 December 2008). Sex-adjusted Cox proportional hazards models were used to estimate hazard ratios for different age groups. 898 patients were included in the analysis; median duration on ART was 468 days. The risk of death were highest in adults compared to young adolescents (aHR 2.25, 95%CI 1.17-4.35). Young adults and adolescents had a 2-3 times higher risk of loss to follow-up compared to young adolescents. When estimating the risk of attrition combining loss to follow-up and death, young adults had the highest risk (aHR 2.70, 95%CI 1.62-4.52). This study highlights the need for adapted adherence support and service delivery models for both adolescents and young adults. DA - 2012 DB - OpenUCT DO - 10.1371/journal.pone.0052856 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Antiretroviral therapy outcomes among adolescents and youth in rural Zimbabwe TI - Antiretroviral therapy outcomes among adolescents and youth in rural Zimbabwe UR - http://hdl.handle.net/11427/14995 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14995
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0052856
dc.identifier.vancouvercitationBygrave H, Mtangirwa J, Ncube K, Ford N, Kranzer K, Munyaradzi D. Antiretroviral therapy outcomes among adolescents and youth in rural Zimbabwe. PLoS One. 2012; http://hdl.handle.net/11427/14995.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2012 Bygrave et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherAdolescentsen_ZA
dc.subject.otherYoung adultsen_ZA
dc.subject.otherAntiretroviral therapyen_ZA
dc.subject.otherDeath ratesen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherZimbabween_ZA
dc.titleAntiretroviral therapy outcomes among adolescents and youth in rural Zimbabween_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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